公开(公告)号：US20190262510A1

公开(公告)日：2019-08-29

申请号：US16407857

申请日：2019-05-09

Applicant: Medtronic, Inc.

Inventor： Xiangji Chen ,  Satish Pulapura

IPC: A61L31/16 ,  A61L31/06 ,  A61L27/54 ,  A61L27/14 ,  A61J1/00

Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.

公开(公告)号：US10736998B2

公开(公告)日：2020-08-11

申请号：US16407857

申请日：2019-05-09

Applicant: Medtronic, Inc.

Inventor： Xiangji Chen ,  Satish Pulapura

IPC: A61L31/16 ,  A61L27/14 ,  A61L27/54 ,  A61J1/00 ,  A61L31/06 ,  A61N1/37 ,  A61N1/375

Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.

公开(公告)号：US10472493B2

公开(公告)日：2019-11-12

申请号：US15498146

申请日：2017-04-26

Applicant: Medtronic, Inc.

Inventor： Patricia E. Dunn ,  Ronald A. Drake ,  Xiangji Chen ,  Samuel E. Owings

IPC: C08K5/29 ,  A61L29/06 ,  C08K3/14 ,  C08K5/3435

Abstract: A composition, article, and method for increasing the hydrolytic stability of a polymer; wherein a composition includes: a polymer comprising functional groups having hydrolyzable bonds; a carbodiimide compound; and a weak base (or hindered amine); wherein the carbodiimide compound and weak base (or hindered amine) are used in amounts effective to decrease the rate and/or extent of hydrolytic degradation of the polymer relative to either used alone in the same amount with the polymer.

公开(公告)号：US11359050B2

公开(公告)日：2022-06-14

申请号：US16936858

申请日：2020-07-23

Applicant: MEDTRONIC, INC.

Inventor： Satish Pulapura ,  Fatima Buevich ,  Xiangji Chen ,  Suping Lyu

IPC: C08G63/81 ,  C08G63/16 ,  C08G63/685

Abstract: A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.

公开(公告)号：US11191878B2

公开(公告)日：2021-12-07

申请号：US16918287

申请日：2020-07-01

Applicant: Medtronic, Inc.

Inventor： Xiangji Chen ,  Satish Pulapura

IPC: A61L31/16 ,  A61L27/14 ,  A61L27/54 ,  A61J1/00 ,  A61L31/06 ,  A61N1/375

Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.

公开(公告)号：US09220888B2

公开(公告)日：2015-12-29

申请号：US13789602

申请日：2013-03-07

Applicant: Medtronic, Inc.

Inventor： Kimberly A. Chaffin ,  Matthew Jolly ,  Darrel F. Untereker ,  Adam J. Buckalew ,  Xiangji Chen ,  Thomas P. Grailer ,  Julie Alkatout

IPC: A61N1/05 ,  A61L29/06 ,  A61L31/06

CPC classification number: A61N1/05 ,  A61L29/06 ,  A61L31/06 ,  A61N1/0526 ,  C08L83/04 ,  C08L75/04

Abstract: Medical leads, such as medical electrical leads and medical neurological leads, that include a polymeric material that includes a silicone-urethane-containing polymer having improved hydrolytic stability.

Abstract translation: 包括包含具有改善的水解稳定性的含硅氧烷聚氨酯的聚合物的聚合物材料的医疗引线，例如医用电线和医学神经导线。

公开(公告)号：US11548974B2

公开(公告)日：2023-01-10

申请号：US17112344

申请日：2020-12-04

Applicant: Medtronic, Inc.

Inventor： Kimberly A. Chaffin ,  Xiangji Chen ,  Matthew Jolly ,  SuPing Lyu ,  Peter L. Thor ,  Darrel F. Untereker ,  Zhaoxu Wang

IPC: C08G18/62 ,  C08G18/76 ,  C08G18/32 ,  A61N1/05 ,  C08G18/10 ,  A61L31/16 ,  A61L31/06 ,  C08G18/65 ,  A61B5/145 ,  A61B5/00 ,  A61N1/36 ,  A61N1/362

Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.

公开(公告)号：US20210115182A1

公开(公告)日：2021-04-22

申请号：US17112344

申请日：2020-12-04

Applicant: Medtronic, Inc.

Inventor： Kimberly A. Chaffin ,  Xiangji Chen ,  Matthew Jolly ,  SuPing Lyu ,  Peter L. Thor ,  Darrel F. Untereker ,  Zhaoxu Wang

IPC: C08G18/62 ,  A61B5/00 ,  A61L31/06 ,  A61L31/16 ,  A61N1/05 ,  C08G18/10 ,  C08G18/32 ,  C08G18/65 ,  C08G18/76 ,  A61B5/145

Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.

公开(公告)号：US10882945B2

公开(公告)日：2021-01-05

申请号：US16359079

申请日：2019-03-20

Applicant: Medtronic, Inc.

Inventor： Kimberly A. Chaffin ,  Xiangji Chen ,  Matthew Jolly ,  SuPing Lyu ,  Peter L. Thor ,  Darrel F. Untereker ,  Zhaoxu Wang

IPC: C08G18/62 ,  C08G18/76 ,  C08G18/32 ,  A61N1/05 ,  C08G18/10 ,  A61L31/16 ,  A61L31/06 ,  C08G18/65 ,  A61B5/145 ,  A61B5/00 ,  A61N1/36 ,  A61N1/362

Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.

公开(公告)号：US20200345901A1

公开(公告)日：2020-11-05

申请号：US16918287

申请日：2020-07-01

Applicant: Medtronic, Inc.

Inventor： Xiangji Chen ,  Satish Pulapura

IPC: A61L31/16 ,  A61L27/14 ,  A61L27/54 ,  A61J1/00 ,  A61L31/06

Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.