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公开(公告)号：US20160166801A1
公开(公告)日：2016-06-16
申请号：US15016081
申请日：2016-02-04
CPC分类号： A61M25/0015 , A61B2017/00526 , A61L31/022 , A61L31/16 , A61M25/0012 , A61N1/0587
摘要： A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.
摘要翻译： 形成中空药物洗脱医疗装置的方法包括提供具有外部构件和设置在外部构件的内腔内的芯构件的复合构件。 复合构件成形为图案。 通过复合构件的外部构件形成开口。 处理复合构件以从外部构件的内腔移除芯构件而不损害外部构件，留下已经形成为期望图案的中空管状构件。 外部构件的内腔填充有治疗物质。
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公开(公告)号：US11540917B2
公开(公告)日：2023-01-03
申请号：US16401235
申请日：2019-05-02
摘要： A system for fracturing a frame of a deployed prosthesis with ultrasonic vibration includes a shaft, a tip assembly, an ultrasonic electric generator, and an ultrasonic transducer. The shaft includes a proximal portion and a distal portion. The tip assembly is coupled to the distal portion of the shaft. The tip assembly includes a cutting edge. The ultrasonic transducer is electrically coupled to the ultrasonic generator. Ultrasonic vibration generated by the ultrasonic transducer is translated to the tip assembly. The cutting edge of the tip assembly is configured to focus the vibration of the tip assembly onto a frame of a deployed prosthesis to fracture the frame of the prosthesis. The ultrasonic transducer may be coupled to the proximal portion or the distal portion of the shaft.
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公开(公告)号：US11517649B2
公开(公告)日：2022-12-06
申请号：US16442740
申请日：2019-06-17
发明人： Syamala Rani Pulugurtha , Jeffrey Allen , James Mitchell , Christopher Storment , Jill Mendelson
摘要： Biodegradable magnesium alloy implantable medical devices are protected to delay onset of corrosion, and thus biodegradability, or to corrode more uniformly. The protection allows for extended effective use of the devices while maintaining biodegradability. Examples of protective coatings include conversion coatings that at least partially remove exposed second phases from a surface of the magnesium alloy and coatings that provide a barrier between water and the surface of the magnesium alloy.
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公开(公告)号：US10322214B2
公开(公告)日：2019-06-18
申请号：US14934645
申请日：2015-11-06
发明人： Syamala Rani Pulugurtha , Jeffrey Allen , James Mitchell , Christopher Storment , Jill Mendelson
摘要： Biodegradable magnesium alloy implantable medical devices are protected to delay onset of corrosion, and thus biodegradability, or to corrode more uniformly. The protection allows for extended effective use of the devices while maintaining biodegradability. Examples of protective coatings include conversion coatings that at least partially remove exposed second phases from a surface of the magnesium alloy and coatings that provide a barrier between water and the surface of the magnesium alloy.
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公开(公告)号：US20230001057A1
公开(公告)日：2023-01-05
申请号：US17941851
申请日：2022-09-09
发明人： Syamala Rani Pulugurtha , Jeffrey Allen , James Mitchell , Christopher Storment , Jill Mendelson
摘要： Biodegradable magnesium alloy implantable medical devices are protected to delay onset of corrosion, and thus biodegradability, or to corrode more uniformly. The protection allows for extended effective use of the devices while maintaining biodegradability. Examples of protective coatings include conversion coatings that at least partially remove exposed second phases from a surface of the magnesium alloy and coatings that provide a barrier between water and the surface of the magnesium alloy.
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6.发明申请公开(公告)号：US20180125685A1
公开(公告)日：2018-05-10
申请号：US15808598
申请日：2017-11-09
发明人： Stefan Tunev , Ryan Bienvenu , Justin Peterson , Carol Sullivan , Christopher Storment , Michael Harms
摘要： A stent includes a hollow wire formed into a stent pattern. The hollow wire includes an outer member, a lumen extending longitudinally within the hollow wire, at least one opening extending from an outer surface of the outer member to the lumen, and a surface area component within the hollow wire. The surface area component increases the amount of surface area available for tissue in-growth within the hollow wire. More than one surface area component may be utilized. Each surface area component may be disposed within the lumen or the at least one opening of the hollow wire. A pharmacologically or biologically active agent may be disposed within the lumen.
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公开(公告)号：US10779972B2
公开(公告)日：2020-09-22
申请号：US15808598
申请日：2017-11-09
发明人： Stefan Tunev , Ryan Bienvenu , Justin Peterson , Carol Sullivan , Christopher Storment , Michael Harms
摘要： A stent includes a hollow wire formed into a stent pattern. The hollow wire includes an outer member, a lumen extending longitudinally within the hollow wire, at least one opening extending from an outer surface of the outer member to the lumen, and a surface area component within the hollow wire. The surface area component increases the amount of surface area available for tissue in-growth within the hollow wire. More than one surface area component may be utilized. Each surface area component may be disposed within the lumen or the at least one opening of the hollow wire. A pharmacologically or biologically active agent may be disposed within the lumen.
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公开(公告)号：US20190298890A1
公开(公告)日：2019-10-03
申请号：US16442740
申请日：2019-06-17
发明人： Syamala Rani Pulugurtha , Jeffrey Allen , James Mitchell , Christopher Storment , Jill Mendelson
摘要： Biodegradable magnesium alloy implantable medical devices are protected to delay onset of corrosion, and thus biodegradability, or to corrode more uniformly. The protection allows for extended effective use of the devices while maintaining biodegradability. Examples of protective coatings include conversion coatings that at least partially remove exposed second phases from a surface of the magnesium alloy and coatings that provide a barrier between water and the surface of the magnesium alloy.
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公开(公告)号：US20160129162A1
公开(公告)日：2016-05-12
申请号：US14934645
申请日：2015-11-06
发明人： Syamala Rani Pulugurtha , Jeffrey Allen , James Mitchell , Christopher Storment , Jill Mendelson
CPC分类号： A61L31/088 , A61F2/89 , A61F2/915 , A61F2002/91541 , A61F2002/91575 , A61F2210/0076 , A61F2230/0069 , A61L31/022 , A61L31/084 , A61L31/10 , A61L31/148 , A61L2420/02 , A61L2420/08 , C23C16/06
摘要： Biodegradable magnesium alloy implantable medical devices are protected to delay onset of corrosion, and thus biodegradability, or to corrode more uniformly. The protection allows for extended effective use of the devices while maintaining biodegradability. Examples of protective coatings include conversion coatings that at least partially remove exposed second phases from a surface of the magnesium alloy and coatings that provide a barrier between water and the surface of the magnesium alloy.
摘要翻译： 可生物降解的镁合金可植入医疗器械得到保护，以延缓腐蚀开始，从而延长生物降解性，或更均匀地腐蚀。 该保护允许在保持生物降解性的同时延长设备的有效使用。 保护性涂层的实例包括至少部分地从镁合金表面除去暴露的第二相的转化涂层和在水与镁合金表面之间提供阻隔的涂层。
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