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公开(公告)号：US20100057034A1
公开(公告)日：2010-03-04
申请号：US12507703
申请日：2009-07-22
申请人： Melissa Dennis , Russell Frederick Ross , Luke Hagan , Thomas Andrew Lutzow , Gerhard Andrew Foelsche , Aidan J. Petrie , Alan Schinazi
发明人： Melissa Dennis , Russell Frederick Ross , Luke Hagan , Thomas Andrew Lutzow , Gerhard Andrew Foelsche , Aidan J. Petrie , Alan Schinazi
CPC分类号： A61F13/82 , A61F13/15203 , A61F13/47209
摘要： A disposable personal care article comprises a shell having a unitary structure for disposition adjacent a wearer's vulva region, where the shell has a first side and a second side, the first side having a first area and a second area. The first area of the shell contacts to the wearer's skin and/or hair surrounding the vulva region. At least a portion of the first area comprises a body attachment means for adhering the shell directly to the skin and/or hair of the wearer. In addition, the shell has an anterior half and a posterior half where the posterior half exhibits a higher extension relative to the anterior half when a stretching force of 454 grams is applied. In some aspects, the article further includes an absorbent structure.
摘要翻译： 一次性个人护理制品包括具有用于邻近穿着者外阴区域的单一结构的外壳，其中外壳具有第一侧和第二侧，第一侧具有第一区域和第二区域。 壳体的第一区域接触穿戴者的皮肤和/或围绕外阴区域的头发。 第一区域的至少一部分包括用于将壳体直接粘附到穿着者的皮肤和/或头发的主体附着装置。 此外，壳体具有前半部和后半部分，当施加454克的拉伸力时，后半部分相对于前半部分呈现较高的延伸。 在一些方面，制品还包括吸收结构。
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公开(公告)号：US08292862B2
公开(公告)日：2012-10-23
申请号：US12507703
申请日：2009-07-22
申请人： Melissa Jean Dennis , Russell Frederick Ross , Luke Hagan , Thomas Andrew Lutzow , Gerhard Andrew Foelsche , Aidan J. Petrie , Alan Schinazi
发明人： Melissa Jean Dennis , Russell Frederick Ross , Luke Hagan , Thomas Andrew Lutzow , Gerhard Andrew Foelsche , Aidan J. Petrie , Alan Schinazi
CPC分类号： A61F13/82 , A61F13/15203 , A61F13/47209
摘要： A disposable personal care article comprises a shell having a unitary structure for disposition adjacent a wearer's vulva region, where the shell has a first side and a second side, the first side having a first area and a second area. The first area of the shell contacts to the wearer's skin and/or hair surrounding the vulva region. At least a portion of the first area comprises a body attachment means for adhering the shell directly to the skin and/or hair of the wearer. In addition, the shell has an anterior half and a posterior half where the posterior half exhibits a higher extension relative to the anterior half when a stretching force of 454 grams is applied. In some aspects, the article further includes an absorbent structure.
摘要翻译： 一次性个人护理制品包括具有用于邻近穿着者外阴区域的单一结构的外壳，其中外壳具有第一侧和第二侧，第一侧具有第一区域和第二区域。 壳体的第一区域接触穿戴者的皮肤和/或围绕外阴区域的头发。 第一区域的至少一部分包括用于将壳体直接粘附到穿着者的皮肤和/或头发的主体附着装置。 此外，壳体具有前半部和后半部分，当施加454克的拉伸力时，后半部分相对于前半部分呈现较高的延伸。 在一些方面，制品还包括吸收结构。
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公开(公告)号：US10245421B2
公开(公告)日：2019-04-02
申请号：US13095489
申请日：2011-04-27
IPC分类号： A61M5/00 , A61M37/00 , A61B17/20 , A61K9/00 , A61K38/19 , A61K9/70 , A61K38/17 , B29C59/00 , B29C59/02 , B29L31/00
摘要： Disclosed are nanotopography-based methods and devices for interacting with a component of the dermal connective tissue. Devices include structures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the plasma membrane of a cell and/or with an extracellular matrix component.
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公开(公告)号：US09522263B2
公开(公告)日：2016-12-20
申请号：US13641501
申请日：2011-04-27
CPC分类号： A61M37/0015 , A61L31/00 , A61M5/158 , A61M2037/0023 , A61M2037/003 , A61M2037/0061 , Y10T29/49
摘要： Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier. The devices include microneedles for penetrating the stratum corneum and also include structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The pattern of structures on the surface of the microneedles may include nano-sized structures.
摘要翻译： 公开了用于在真皮屏障上递送类风湿性关节炎药物的装置。 这些装置包括用于穿透角质层的微针，还包括在微针的表面上制造以形成纳米形貌的结构。 可以制造随机或非随机的结构图案，例如包括不同尺寸和/或形状的结构的复杂图案。 微针表面上的结构图案可以包括纳米尺寸的结构。
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公开(公告)号：US20120316503A1
公开(公告)日：2012-12-13
申请号：US13157412
申请日：2011-06-10
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0038
摘要： The present invention includes a microneedle assembly having a support that includes a first surface and a second surface, the second surface further including a slanted surface. A plurality of microneedles are provided which project outwardly from the second surface of the support. A pathway through the microneedle assembly is formed and includes an aperture extending between the first surface of the support and the second surface of the support, a channel disposed on the exterior surface of at least one microneedle, the channel having a surface, the channel being in alignment with at least a portion of the aperture to form a junction through which fluids may pass.
摘要翻译： 本发明包括具有包括第一表面和第二表面的支撑件的微针组件，所述第二表面还包括倾斜表面。 提供了多个微针，其从支撑件的第二表面向外突出。 形成通过微针组件的路径，并且包括在支撑件的第一表面和支撑件的第二表面之间延伸的孔，设置在至少一个微针的外表面上的通道，通道具有表面，通道为 与孔的至少一部分对准以形成流体可以通过的连接点。
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6.发明授权公开(公告)号：US06455447B1
公开(公告)日：2002-09-24
申请号：US09465504
申请日：1999-12-15
IPC分类号： B32B2704
CPC分类号： D21F1/30 , D21F1/0027 , Y10T442/2139 , Y10T442/2287 , Y10T442/2861 , Y10T442/2893 , Y10T442/291 , Y10T442/2926
摘要： A paper machine substrate modified to resist contamination by adhesive materials. The paper machine substrate includes: a paper machine substrate; and an active agent that is grafted to the surface of the paper machine substrate to lower the surface energy of the paper machine substrate so that the substrate resists contamination by adhesive material. The papermachine substrate may be made by a process that includes the steps of: providing a paper machine substrate; applying an active agent to the paper machine substrate; and exposing the paper machine substrate to greater than about 2 million rads (Mrad) of radiation to cause a reaction between the active agent and the substrate so the active agent becomes joined to the substrate. The active agent may be a fluorinated monomer, a fluorinated polymer, a perfluorinated polymers, or a polyalkyl siloxane.
摘要翻译： 修改成抵抗粘合剂材料污染的造纸机基材。 造纸机基板包括：造纸机基板; 以及接枝到造纸机基材的表面的活性剂，以降低造纸机基材的表面能，使得基材抵抗粘合剂材料的污染。 造纸机基材可以通过包括以下步骤的方法制备：提供造纸机基材; 将活性剂施加到造纸机基材上; 并将造纸机基板暴露于大于约200万弧度（Mrad）的辐射以引起活性剂和基底之间的反应，使得活性剂与基底结合。 活性剂可以是氟化单体，氟化聚合物，全氟化聚合物或聚烷基硅氧烷。
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公开(公告)号：US20120107570A1
公开(公告)日：2012-05-03
申请号：US12938756
申请日：2010-11-03
CPC分类号： A61F13/5611 , A61F13/5616 , A61F13/58 , B29C53/22 , C09J7/00 , C09J2201/626
摘要： An adhesive material that contains a plurality of setae that include a stalk and spatula extending therefrom is provided. To form the adhesive material, a substantially planar substrate may be initially molded to define the setae. In this initial configuration, the setae are positioned substantially in the plane of the substrate. The substrate is then physically manipulated (e.g., folded, bent, corrugated, rotated, etc.) so that the setae become extended in an outwardly direction from the plane. Among other things, this provides a three-dimensional material having enhanced adhesive properties.
摘要翻译： 提供了一种粘合剂材料，其包含多个包括从其延伸的茎和刮刀的固化物。 为了形成粘合剂材料，可以初始地模制基本平坦的基底以限定刚毛。 在该初始构造中，固定基本上位于基底的平面中。 然后，物理地操纵衬底（例如，折叠，弯曲，波纹状，旋转等），使得刚毛从平面向外的方向延伸。 除此之外，这提供了具有增强的粘合性质的三维材料。
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8.发明授权公开(公告)号：US09545507B2
公开(公告)日：2017-01-17
申请号：US13641507
申请日：2011-04-27
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0021 , A61K9/7023 , A61K38/1793 , A61K38/191 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0053 , A61M2037/0061 , B29C59/002 , B29C59/026 , B29C2059/023 , B29K2995/0056 , B29L2031/7544 , B29L2031/756 , Y10T156/10 , Y10T156/1039 , Y10T156/1057
摘要： Disclosed are injection molded devices including microneedles on a substrate base. The microneedles may include a plurality of nano-sized structures fabricated thereon. The molds used to form the microneedles are assembled from a plurality of mold segments, each defining portions of the microneedles. Upon assembly of the multiple mold segments, microneedle negative cavities are formed. The molds may be used in an injection molding process to form microneedle arrays. Devices may be utilized for interacting with a component of the dermal connective tissue.
摘要翻译： 本发明公开了一种注射成型装置，其包括在基底上的微针。 微针可以包括在其上制造的多个纳米尺寸结构。 用于形成微针的模具由多个模具段组装，每个模具段限定微针的部分。 在组装多个模具段时，形成微针负空腔。 模具可以用于注射成型工艺以形成微针阵列。 装置可用于与真皮结缔组织的组分相互作用。
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公开(公告)号：US08636696B2
公开(公告)日：2014-01-28
申请号：US13157412
申请日：2011-06-10
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0038
摘要： The present invention includes a microneedle assembly having a support that includes a first surface and a second surface, the second surface further including a slanted surface. A plurality of microneedles are provided which project outwardly from the second surface of the support. A pathway through the microneedle assembly is formed and includes an aperture extending between the first surface of the support and the second surface of the support, a channel disposed on the exterior surface of at least one microneedle, the channel having a surface, the channel being in alignment with at least a portion of the aperture to form a junction through which fluids may pass.
摘要翻译： 本发明包括具有包括第一表面和第二表面的支撑件的微针组件，所述第二表面还包括倾斜表面。 提供了多个微针，其从支撑件的第二表面向外突出。 形成通过微针组件的路径，并且包括在支撑件的第一表面和支撑件的第二表面之间延伸的孔，设置在至少一个微针的外表面上的通道，通道具有表面，通道为 与孔的至少一部分对准以形成流体可以通过的连接点。
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公开(公告)号：US20130158505A1
公开(公告)日：2013-06-20
申请号：US13641502
申请日：2011-04-27
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M5/158 , A61M37/00 , A61M2037/0023 , A61M2037/0038 , A61M2037/0053 , A61M2037/0061 , C12N15/113 , C12N15/89 , C12N2310/14 , Y10T29/49826
摘要： Disclosed are medical devices that incorporate siRNA. In addition to one or more siRNA constructs, devices include nanostructures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be incorporated on devices. The pattern including nanostructures may be formed on the surface of the microneedles.
摘要翻译： 公开了掺入siRNA的医疗器械。 除了一种或多种siRNA构建体之外，装置包括在表面上制造以形成纳米形貌的纳米结构。 可以制造随机或非随机的结构图案，例如包括不同尺寸和/或形状的结构的复杂图案。 微针可以并入设备上。 包括纳米结构的图案可以形成在微针的表面上。
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