公开(公告)号：US20180169241A1

公开(公告)日：2018-06-21

申请号：US15843603

申请日：2017-12-15

申请人： Memgen, LLC

发明人： Mark J. Cantwell

IPC分类号： A61K39/42 ,  C07K14/705 ,  A61P35/00

摘要： Disclosed are oncolytic viruses comprising chimeric human/mouse CD40 ligands. The chimeric human/mouse CD40 ligand may be MEM40. The oncolytic virus may be replication competent. The oncolytic virus may be an oncolytic herpes simplex virus. Also disclosed are methods comprising administering an oncolytic virus armed with at least one chimeric human/mouse CD40 ligand, for example MEM40, to a patient suffering from cancer.

公开(公告)号：US20180244750A1

公开(公告)日：2018-08-30

申请号：US15773090

申请日：2016-11-02

申请人： Memgen, LLC

发明人： Mark J. Cantwell

IPC分类号： C07K14/705 ,  A61P35/00 ,  C12N7/00 ,  G01N33/574 ,  A61K39/395 ,  A61K38/17

CPC分类号： C07K14/70575 ,  A61K38/177 ,  A61K39/39558 ,  A61K48/00 ,  A61P35/00 ,  C12N7/00 ,  C12N2710/10021 ,  C12N2710/10043 ,  C12N2710/10071 ,  C12N2710/10343 ,  G01N33/57492

摘要： Provided herein are methods of sensitizing cancer cells to treatment with inhibitors of the PD-1 pathway. Such methods comprise treatment of subject with a checkpoint inhibitor refractory cancer with an expression vector encoding a chimeric CD154.

公开(公告)号：US11298420B2

公开(公告)日：2022-04-12

申请号：US15843603

申请日：2017-12-15

申请人： Memgen, LLC

发明人： Mark J. Cantwell

IPC分类号： A61K39/42 ,  A61K38/17 ,  C07K14/705 ,  A61P35/00 ,  A61K39/00

摘要： Disclosed are oncolytic viruses comprising chimeric human/mouse CD40 ligands. The chimeric human/mouse CD40 ligand may be MEM40. The oncolytic virus may be replication competent. The oncolytic virus may be an oncolytic herpes simplex virus. Also disclosed are methods comprising administering an oncolytic virus armed with at least one chimeric human/mouse CD40 ligand, for example MEM40, to a patient suffering from cancer.

公开(公告)号：US20180169271A1

公开(公告)日：2018-06-21

申请号：US15847612

申请日：2017-12-19

申请人： Memgen, LLC ,  DNAtrix

发明人： Mark J. Cantwell ,  Winnie M. Chan ,  Brett Ewald ,  Joan M. Robbins

IPC分类号： A61K48/00 ,  C07K14/705 ,  C12N15/86 ,  A61K38/17 ,  A61K45/06

CPC分类号： A61K48/0058 ,  A61K35/761 ,  A61K38/17 ,  A61K38/177 ,  A61K45/06 ,  C07K14/70575 ,  C12N15/86 ,  C12N2710/10033 ,  C12N2710/10043 ,  C12N2830/60

摘要： Disclosed are replication-competent oncolytic adenoviruses, comprising chimeric human/mouse CD40 ligands. The oncolytic adenoviruses may be replication competent. The chimeric human/mouse CD40 ligand may be MEM40. Also disclosed are methods comprising administering a replication competent oncolytic adenovirus armed with at least one chimeric human/mouse CD40 ligand, for example MEM40, to a patient suffering from a cancer.