公开(公告)号：US11091547B2

公开(公告)日：2021-08-17

申请号：US15526309

申请日：2015-11-12

申请人： Memorial Sloan Kettering Cancer Center ,  The General Hospital Corporation

发明人： Soldano Ferrone ,  Nai-Kong V. Cheung ,  Ming Cheng

IPC分类号： C07K16/00 ,  C07H21/04 ,  C12N5/12 ,  C07K16/28 ,  C07K16/30 ,  C07K16/44 ,  A61K39/00

摘要： Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (CSPG4) and, in particular, chimeric and humanized anti-CSPG4 antibodies and fragments thereof. Also provided herein are methods of using individual humanized antibodies or compositions thereof for the detection, prevention, and/or therapeutic treatment of CSPG4-related diseases, in particular, melanoma.

公开(公告)号：US20170342151A1

公开(公告)日：2017-11-30

申请号：US15526309

申请日：2015-11-12

申请人： Memorial Sloan Kettering Cancer Center ,  The General Hospital Corporation

发明人： Soldano Ferrone ,  Nai-Kong V. Cheung ,  Ming Cheng

IPC分类号： C07K16/28 ,  C07K16/44 ,  C07K16/30 ,  A61K39/00

CPC分类号： C07K16/2809 ,  A61K2039/505 ,  C07K16/3053 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/92

摘要： Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (CSPG4) and, in particular, chimeric and humanized anti-CSPG4 antibodies and fragments thereof. Also provided herein are methods of using individual humanized antibodies or compositions thereof for the detection, prevention, and/or therapeutic treatment of CSPG4-related diseases, in particular, melanoma.

公开(公告)号：US10881711B2

公开(公告)日：2021-01-05

申请号：US15564580

申请日：2016-04-06

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： Soldano Ferrone ,  Xinhui Wang

IPC分类号： C07K16/00 ,  A61K39/395 ,  A61K38/17 ,  C07K14/47 ,  A61K45/06 ,  C07K16/30 ,  G01N33/574 ,  A61P35/00 ,  A61K38/00

摘要： Embodiments of the present invention provide antibodies, antigen binding portions thereof, and other polypeptides (e.g., CARs), that specifically bind to CSPG4, an antigen expressed on cancer cells. Monoclonal antibodies, antibody-drug conjugates, and/or CAR-T-cells that specifically bind to CSPG4 positive cancer cells are also provided.

公开(公告)号：US10519214B2

公开(公告)日：2019-12-31

申请号：US16262490

申请日：2019-01-30

申请人： The University of North Carolina at Chapel Hill ,  The General Hospital Corporation

发明人： Gianpietro Dotti ,  Soldano Ferrone ,  Hongwei Du ,  Xinhui Wang ,  Cristina Ferrone

IPC分类号： C07K14/705 ,  A61P35/00 ,  G01N33/574 ,  A61K35/17 ,  A61K38/00

摘要： The present invention provides a chimeric antigen receptor (CAR) that recognizes B7-H3 (CD276), as well as methods of use in the treatment of diseases and disorders.

公开(公告)号：US10233226B2

公开(公告)日：2019-03-19

申请号：US16012432

申请日：2018-06-19

申请人： The University of North Carolina at Chapel Hill ,  The General Hospital Corporation

发明人： Gianpietro Dotti ,  Soldano Ferrone ,  Hongwei Du ,  Xinhui Wang ,  Cristina Ferrone

IPC分类号： C07K14/705 ,  A61K35/17 ,  G01N33/574 ,  A61P35/00

摘要： The present invention provides a chimeric antigen receptor (CAR) that recognizes B7-H3 (CD276), as well as methods of use in the treatment of diseases and disorders.

公开(公告)号：US20180371053A1

公开(公告)日：2018-12-27

申请号：US16012432

申请日：2018-06-19

申请人： The University of North Carolina at Chapel Hill ,  The General Hospital Corporation

发明人： Gianpietro Dotti ,  Soldano Ferrone ,  Hongwei Du ,  Xinhui Wang ,  Cristina Ferrone

IPC分类号： C07K14/705 ,  A61K35/17 ,  G01N33/574 ,  A61P35/00

摘要： The present invention provides a chimeric antigen receptor (CAR) that recognizes B7-H3 (CD276), as well as methods of use in the treatment of diseases and disorders.

公开(公告)号：US11725061B2

公开(公告)日：2023-08-15

申请号：US15965333

申请日：2018-04-27

申请人： Baylor College of Medicine ,  The General Hospital Corporation

发明人： Gianpietro Dotti ,  Soldano Ferrone

IPC分类号： C07K16/30 ,  A61K35/17 ,  C07K14/705 ,  C07K14/725 ,  A61K39/00

CPC分类号： C07K16/3076 ,  A61K35/17 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/70596 ,  C07K16/30 ,  A61K2039/505 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2319/01 ,  C07K2319/03 ,  C07K2319/30

摘要： Embodiments of the disclosure include methods and compositions related to chimeric antigen receptors (CAR) that target chondroitin sulfate proteoglycan-4 (CSPG4). T cells transduced with a CSPG4-specific CAR are effective for inhibition of particular cancer cells that express CSPG4. In certain embodiments, the cancer is melanoma, breast cancer, head and neck cancer, mesothelioma, glioblastoma, or renal cancer.

公开(公告)号：US20200369743A1

公开(公告)日：2020-11-26

申请号：US16730951

申请日：2019-12-30

申请人： The University of North Carolina at Chapel Hill ,  The General Hospital Corporation

发明人： Gianpietro Dotti ,  Soldano Ferrone ,  Hongwei Du ,  Xinhui Wang ,  Cristina Ferrone

IPC分类号： C07K14/705 ,  A61P35/00 ,  G01N33/574 ,  A61K35/17

摘要： The present invention provides a chimeric antigen receptor (CAR) that recognizes B7-H3 (CD276), as well as methods of use in the treatment of diseases and disorders.

公开(公告)号：US20190153063A1

公开(公告)日：2019-05-23

申请号：US16262490

申请日：2019-01-30

申请人： The University of North Carolina at Chapel Hill ,  The General Hospital Corporation

发明人： Gianpietro Dotti ,  Soldano Ferrone ,  Hongwei Du ,  Xinhui Wang ,  Cristina Ferrone

IPC分类号： C07K14/705 ,  A61P35/00 ,  G01N33/574 ,  A61K35/17

CPC分类号： C07K14/70521 ,  A61K35/17 ,  A61K38/00 ,  A61P35/00 ,  C07K14/70532 ,  C07K14/70596 ,  G01N33/574 ,  G01N33/57492

摘要： The present invention provides a chimeric antigen receptor (CAR) that recognizes B7-H3 (CD276), as well as methods of use in the treatment of diseases and disorders.

公开(公告)号：US20210252067A1

公开(公告)日：2021-08-19

申请号：US17251397

申请日：2019-05-24

申请人： The University of North Carolina at Chapel Hill ,  The General Hospital Corporation

发明人： Gianpietro Dotti ,  Soldano Ferrone ,  Hannah Reid Hudson ,  Elena Dukhovlinova ,  Cristina Ferrone ,  Xinhui Wang

IPC分类号： A61K35/17 ,  C07K14/725 ,  C07K16/30 ,  G01N33/50

摘要： The present invention provides a chimeric antigen receptor (CAR) that recognizes CSPG4 as well as methods of use in the treatment of diseases and disorders.