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公开(公告)号:US10947214B2
公开(公告)日:2021-03-16
申请号:US15670068
申请日:2017-08-07
申请人: Merck Patent GmbH
发明人: Brian A. Sherer , Xiaoling Chen , Esther Cleary , Nadia Brugger
IPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D215/18 , C07D413/04 , C07D401/12 , A61K31/4709 , C07D215/12 , C07D215/14 , C07D241/42 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04
摘要: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TLR7/8 antagonists.
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公开(公告)号:US20200317622A1
公开(公告)日:2020-10-08
申请号:US16843735
申请日:2020-04-08
申请人: MERCK PATENT GMBH
发明人: Catherine Jorand-Lebrun , Roch Boivin , Theresa Johnson , Yanping Wang , Yufang Xiao , Xiaoling Chen , Nina Linde , Doreen Musch , Deepak Kumar
IPC分类号: C07D239/36 , A61P35/00 , C07D401/04 , C07D491/107 , C07D491/052 , C07D403/04 , C07D487/10 , C07D239/42 , C07D401/14 , C07D471/10 , C07D491/20
摘要: The invention relates to pyrimidinone derivatives of the general Formula I, or a pharmaceutically acceptable salt thereof, and the use of the compounds of the present invention for the treatment of hyperproliferative diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.
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公开(公告)号:US10080750B2
公开(公告)日:2018-09-25
申请号:US15490370
申请日:2017-04-18
申请人: Merck Patent GmbH
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Lizbeth C. Deselm , Hui Qiu , Yufang Xiao , Constantin Neagu , Igor Mochalkin , Theresa L. Johnson
IPC分类号: A61K31/506 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D239/48 , C07D413/04 , C07D417/14 , C07D405/12 , C07D417/12 , C07D239/49 , C07D413/06
CPC分类号: A61K31/506 , C07D239/48 , C07D239/49 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
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公开(公告)号:US09458134B2
公开(公告)日:2016-10-04
申请号:US14775205
申请日:2014-03-10
申请人: Merck Patent GmbH
发明人: Ruoxi Lan , Xiaoling Chen , Yufang Xiao , Bayard R. Huck , Andreas Goutopoulos
IPC分类号: A61K31/506 , C07D401/14 , A61K31/519 , C07D487/04
CPC分类号: A61K31/519 , A61K31/506 , C07D401/14 , C07D487/04
摘要: The invention provides novel heterocyclic amines according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型杂环胺,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20140309245A1
公开(公告)日:2014-10-16
申请号:US14359937
申请日:2012-12-17
申请人: Merck Patent GmbH
发明人: Bayard R. Huck , Xiaoling Chen , Yufang Xiao , Ruoxi Lan , Lizbeth Celeste De Selm , Constantin Neagu , Justin Potnick , Srinivasa R. Karra , Theresa L. Johnson
IPC分类号: C07D403/12 , C07D401/12
CPC分类号: A61K31/517 , A61K31/47 , A61K31/4709 , A61K31/496 , C07D215/48 , C07D239/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12
摘要: The invention provides novel heterocyclic carboxamide compounds compounds according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了根据式(I)的新型杂环羧酰胺化合物其用于治疗过度增殖性疾病如癌症的制造和用途。
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公开(公告)号:US20200369648A1
公开(公告)日:2020-11-26
申请号:US16947691
申请日:2020-08-13
申请人: Merck Patent GmbH
发明人: Brian A. Sherer , Nadia Brugger , Ruoxi Lan , Xiaoling Chen
IPC分类号: C07D403/10 , A61P9/10 , A61P29/00 , A61P19/02 , A61P35/00 , A61P3/10 , C07D401/14 , C07D401/10 , A61P25/16 , A61P25/28 , A61P17/06 , C07D471/04
摘要: Compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TLR7/8 antagonists, are described herein.
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公开(公告)号:US10836750B1
公开(公告)日:2020-11-17
申请号:US16947691
申请日:2020-08-13
申请人: Merck Patent GmbH
发明人: Brian A. Sherer , Nadia Brugger , Ruoxi Lan , Xiaoling Chen
IPC分类号: C07D403/10 , A61P9/10 , A61P29/00 , A61P19/02 , A61P35/00 , C07D471/04 , C07D401/14 , C07D401/10 , A61P25/16 , A61P25/28 , A61P17/06 , A61P3/10
摘要: Compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TLR7/8 antagonists, are described herein.
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公开(公告)号:US09850255B2
公开(公告)日:2017-12-26
申请号:US15277479
申请日:2016-09-27
申请人: Merck Patent GmbH
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Yufang Xiao
IPC分类号: A01N43/90 , A61K31/519 , C07D475/00 , C07D498/04 , C07D475/06 , C07D487/04 , A61K31/496 , A61K31/517 , A61K31/5383 , A61K45/06 , A61N5/10 , C07D239/70 , C07D471/04
CPC分类号: C07D498/04 , A61K31/496 , A61K31/517 , A61K31/519 , A61K31/5383 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07D239/70 , C07D471/04 , C07D475/06 , C07D487/04
摘要: The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R1, R2, W, X1, X2, X3, X4 and n have the meanings indicated in formula I, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
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公开(公告)号:US09815836B2
公开(公告)日:2017-11-14
申请号:US15620049
申请日:2017-06-12
申请人: Merck Patent GmbH
发明人: Xiaoling Chen , Henry Yu , Ruoxi Lan , Catherine Jorand-Lebrun , Theresa L. Johnson , Andreas Goutopoulos
IPC分类号: C07D471/22 , C07D498/18 , C07D498/22 , C07D513/22 , C07D487/18
CPC分类号: C07D471/22 , C07D487/18 , C07D498/18 , C07D498/22 , C07D513/22
摘要: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
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公开(公告)号:US09708324B2
公开(公告)日:2017-07-18
申请号:US15016569
申请日:2016-02-05
申请人: Merck Patent GmbH
发明人: Xiaoling Chen , Henry Yu , Ruoxi Lan , Catherine Jorand-Lebrun , Theresa L. Johnson , Andreas Goutopoulos
IPC分类号: C07D471/22 , C07D487/18 , C07D498/18 , C07D498/22 , C07D513/22
CPC分类号: C07D471/22 , C07D487/18 , C07D498/18 , C07D498/22 , C07D513/22
摘要: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
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