公开(公告)号：US20200062798A1

公开(公告)日：2020-02-27

申请号：US16611624

申请日：2018-05-07

申请人： Wen-Lian WU ,  Jongwon LIM ,  Jared N. CUMMING ,  Benjamin Wesley TROTTER ,  Wonsuk CHANG ,  Merck Sharp & Dohme Corp.

发明人： Wen-Lian WU ,  Jongwon LIM ,  Jared N. Cumming ,  Benjamin Wesley TROTTER ,  Wonsuk CHANG

IPC分类号： C07H21/00

摘要： A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

公开(公告)号：US20210130466A1

公开(公告)日：2021-05-06

申请号：US16635059

申请日：2018-07-30

申请人： Saso CEMERSKI ,  Jared N. CUMMING ,  Johnny E. KOPINJA ,  Samanthi A. PERERA ,  Benjamin Wesley TROTTER ,  Archie Ngai-Chiu TSE ,  Merck Sharp & Dohme Corp.

发明人： Saso CEMERSKI ,  Jared N. CUMMING ,  Johnny E. KOPINJA ,  Samanthi A. PERERA ,  Benjamin Wesley TROTTER ,  Archie Ngai-Chiu TSE

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K31/381

摘要： Therapeutic combinations that comprise at least one antagonist of the Programmed Death 1 receptor (PD-1) and at least one benzo[b]thiophene compound that activates the Stimulator of Interferon Genes (STING) pathway are disclosed herein. Also disclosed is the use of such therapeutic combinations for the treatment of cancers.

公开(公告)号：US20200330427A1

公开(公告)日：2020-10-22

申请号：US16635074

申请日：2018-07-30

申请人： Merck Sharp & Dohme Corp.

发明人： Saso CEMERSKI ,  Jared N. CUMMING ,  Johnny E. KOPINJA ,  Samanthi A. PERERA ,  Benjamin Wesley TROTTER ,  Archie Ngai-Chiu TSE

IPC分类号： A61K31/381 ,  A61P35/00 ,  A61P35/04 ,  A61K9/00

摘要： Therapies comprising administering at least one benzo[b]thiophene compound that activates the Stimulator of Interferon Genes (STING) pathway, and the use of such therapies in the treatment of cell-proliferation disorders such as cancer, are disclosed herein.