公开(公告)号：US20170073354A1

公开(公告)日：2017-03-16

申请号：US15124635

申请日：2015-03-06

申请人： Jurgen SCHULZ ,  Peter D. WILLIAMS ,  John A. MCCAULEY ,  Christopher J. BUNGARD ,  David Jonathan BENNETT ,  Sherman T. WADDELL ,  Gregori J. MORRIELLO ,  Lehua CHANG ,  Michael P. DWYER ,  Katharine M. HOLLOWAY ,  Alejandro CRESPO ,  Xin-Jie CHU ,  Catherine WISCOUNT ,  Marie H. LOUGHRAN ,  Jesse J. MANIKOWSKI ,  Kartik M. KEERTIKAR ,  Bin HU ,  Bin ZHONG ,  Tao JI ,  Merck Sharp & Dohme Corp. ,  MSD R&D (China) Co., Ltd.

发明人： Peter D. Williams ,  John A. McCauley ,  Christopher J. Bungard ,  David Jonathan Bennett ,  Sherman T. Waddell ,  Gregori J. Morriello ,  Lehua Chang ,  Michael P. Dwyer ,  M. Katharine Holloway ,  Alejandro Crespo ,  Xin-Jie Chu ,  Catherine Wiscount ,  H. Marie Loughran ,  Jesse J. Manikowski ,  Jurgen Schulz ,  Kartik M. Keertikar ,  Bin Hu ,  Bin Zhong ,  Tao Ji

IPC分类号： C07D513/08 ,  A61K31/554 ,  A61K45/06

CPC分类号： C07D513/08 ,  A61K31/554 ,  A61K45/06

摘要： The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

摘要翻译： 本发明涉及含有该化合物的式I药物组合物的化合物及其在抑制HIV蛋白酶，抑制HIV复制，预防HIV感染，HIV感染治疗和预防， 治疗和延迟艾滋病的发病或进展。

公开(公告)号：US10138255B2

公开(公告)日：2018-11-27

申请号：US15124635

申请日：2015-03-06

申请人： Merck Sharp & Dohme Corp. ,  MSD R&D (China) Co., Ltd.

发明人： Peter D. Williams ,  John A. McCauley ,  Christopher J. Bungard ,  David Jonathan Bennett ,  Sherman T. Waddell ,  Gregori J. Morriello ,  Lehua Chang ,  Michael P. Dwyer ,  M. Katharine Holloway ,  Alejandro Crespo ,  Xin-Jie Chu ,  Catherine Wiscount ,  H. Marie Loughran ,  Jesse J. Manikowski ,  Jurgen Schulz ,  Kartik M. Keertikar ,  Bin Hu ,  Bin Zhong ,  Tao Ji

IPC分类号： A61K31/554 ,  C07D513/08 ,  A61K45/06

摘要： The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.