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公开(公告)号：USD1047217S1
公开(公告)日：2024-10-15
申请号：US29946539
申请日：2024-06-10
申请人： Bin Zhong
设计人： Bin Zhong
摘要： FIG. 1 is a front, right and top perspective view of an eye massager, showing my design.
FIG. 2 is a rear, left and bottom perspective view thereof.
FIG. 3 is a front elevation view thereof.
FIG. 4 is a rear elevation view thereof.
FIG. 5 is a left side elevation view thereof.
FIG. 6 is a right side elevation view thereof.
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The dashed broken lines depict portions of the eye massager that form no part of the claimed design.-
2.发明授权Tetracyclic xanthene derivatives and methods of use thereof for the treatment of viral diseases 有权四环呫吨衍生物及其用于治疗病毒性疾病的方法公开(公告)号：US09504690B2
公开(公告)日：2016-11-29
申请号：US14005430
申请日：2012-03-16
申请人： Craig A. Coburn , Stuart B. Rosenblum , Joseph A. Kozlowski , Richard Soll , Hao Wu , Bin Hu , Bin Zhong , Dahai Wang , Changmao Shen , Fei Sun
发明人： Craig A. Coburn , Stuart B. Rosenblum , Joseph A. Kozlowski , Richard Soll , Hao Wu , Bin Hu , Bin Zhong , Dahai Wang , Changmao Shen , Fei Sun
IPC分类号： A61K31/535 , A61K31/5383 , C07D491/06 , C07D498/06 , A61K31/4178 , A61K45/06 , C07D493/06
CPC分类号： A61K31/5383 , A61K31/4178 , A61K45/06 , C07D491/06 , C07D493/06 , C07D498/06
摘要： The present invention relates to novel Tetracyclic Xanthene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y1, Y2, Z, Ra, Rb, R1a, R1b and R2 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Xanthene Derivative, and methods of using the Tetracyclic Xanthene Derivatives for treating or preventing HCV infection in a patient.
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公开(公告)号：US09102125B2
公开(公告)日：2015-08-11
申请号：US13390956
申请日：2010-08-26
IPC分类号： B29D22/00 , B32B27/08 , B65D65/40 , B41M7/02 , B32B27/36 , B41M7/00 , B32B27/32 , C09D193/02
CPC分类号： B32B27/08 , B32B9/02 , B32B9/04 , B32B15/04 , B32B15/20 , B32B27/06 , B32B27/304 , B32B27/306 , B32B27/32 , B32B27/34 , B32B27/36 , B32B2255/00 , B32B2255/06 , B32B2255/10 , B32B2255/26 , B32B2270/00 , B32B2307/412 , B32B2307/546 , B32B2307/7163 , B32B2307/7244 , B32B2307/7246 , B32B2307/75 , B32B2439/70 , B32B2439/80 , B41M7/0036 , B41M7/0045 , B41M7/02 , B65D65/40 , C09D193/02 , Y10T428/1334 , Y10T428/1379 , Y10T428/24851 , C08L71/02 , C08L89/00 , C08L1/28
摘要： The printed image on a major face of a flexible food packaging film is covered by a shellac barrier coating.
摘要翻译： 柔性食品包装膜的主面上的印刷图像被虫胶屏障涂层覆盖。
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公开(公告)号：US20110236537A1
公开(公告)日：2011-09-29
申请号：US13133273
申请日：2009-12-07
申请人： Bin Zhong , Xiangdong Gan
发明人： Bin Zhong , Xiangdong Gan
IPC分类号： A23G3/54
摘要： The gloss of iced frozen baked goods once thawed, is enhanced by coating the baked goods with shellac prior to freezing.
摘要翻译： 一旦解冻的冰冻冷冻烘焙食品的光泽度，在冻结之前用紫胶包衣烘焙食品可以增强。
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5.发明申请公开(公告)号：US20190185486A1
公开(公告)日：2019-06-20
申请号：US16326043
申请日：2017-08-14
申请人： Wensheng Yu , Joseph A. Kozlowski , Ling Tong , Craig A. Cobum , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
发明人： Wensheng Yu , Joseph A. Kozlowski , Ling Tong , Craig A. Cobum , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
IPC分类号： C07D498/04 , A61K31/5365 , A61K31/496 , A61K45/06 , A61P31/14
摘要： The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising a Chromane-Substituted Tetracyclic Compound, and methods of using the Chromane-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号：US20170217940A1
公开(公告)日：2017-08-03
申请号：US15104584
申请日：2014-12-15
申请人： Joseph KOZLOWSKI , Craig COBURN , Wensheng YU , Bin HU , Bin ZHONG , Jinglai HAO , Dahai WANG , Tao JI , MERCL SHARP & DOHME CORP.
发明人： Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
IPC分类号： C07D405/14 , A61K31/4178 , A61K31/7072 , A61K45/06 , A61K31/4985
CPC分类号： C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/4985 , A61K31/7072 , A61K45/06 , C07D493/04 , A61K2300/00
摘要： The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A′, R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The present invention also relates to pharmaceutical compositions comprising at least one Fused Tetracyclic Heterocyclic Compound, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines, and methods of using the Fused Tetracyclic Heterocyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号：US08871759B2
公开(公告)日：2014-10-28
申请号：US13260684
申请日：2010-03-25
申请人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
发明人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
IPC分类号： A61K31/5365 , C07D413/14
CPC分类号： C07D498/04 , A61K31/4025 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K38/05 , A61K38/06 , A61K45/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07K5/06 , C07K5/08
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5A抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5A活性用于治疗或预防HCV感染的用途的式（I）化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。
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公开(公告)号：US20120207887A1
公开(公告)日：2012-08-16
申请号：US13390956
申请日：2010-08-26
CPC分类号： B32B27/08 , B32B9/02 , B32B9/04 , B32B15/04 , B32B15/20 , B32B27/06 , B32B27/304 , B32B27/306 , B32B27/32 , B32B27/34 , B32B27/36 , B32B2255/00 , B32B2255/06 , B32B2255/10 , B32B2255/26 , B32B2270/00 , B32B2307/412 , B32B2307/546 , B32B2307/7163 , B32B2307/7244 , B32B2307/7246 , B32B2307/75 , B32B2439/70 , B32B2439/80 , B41M7/0036 , B41M7/0045 , B41M7/02 , B65D65/40 , C09D193/02 , Y10T428/1334 , Y10T428/1379 , Y10T428/24851 , C08L71/02 , C08L89/00 , C08L1/28
摘要： The printed image on a major face of a flexible food packaging film is covered by a shellac barrier coating.
摘要翻译： 柔性食品包装膜的主面上的印刷图像被虫胶屏障涂层覆盖。
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9.发明申请公开(公告)号：US20190175602A1
公开(公告)日：2019-06-13
申请号：US16326039
申请日：2017-08-14
申请人： Wensheng Yu , LING Tong , Joseph A. Koziowski , Craig: A Coburn , De-yi J. Yang , Deyou Sha , Jae-Hun. Kim , Michael Dwyer , Kartik M. Keertikar , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
发明人： Wensheng Yu , LING Tong , Joseph A. Koziowski , Craig: A Coburn , De-yi J. Yang , Deyou Sha , Jae-Hun. Kim , Michael Dwyer , Kartik M. Keertikar , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
IPC分类号： A61K31/5365 , C07D498/04 , A61P31/14 , A61K31/4995 , C07D519/00
摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetra-cyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号：US20170073354A1
公开(公告)日：2017-03-16
申请号：US15124635
申请日：2015-03-06
申请人： Jurgen SCHULZ , Peter D. WILLIAMS , John A. MCCAULEY , Christopher J. BUNGARD , David Jonathan BENNETT , Sherman T. WADDELL , Gregori J. MORRIELLO , Lehua CHANG , Michael P. DWYER , Katharine M. HOLLOWAY , Alejandro CRESPO , Xin-Jie CHU , Catherine WISCOUNT , Marie H. LOUGHRAN , Jesse J. MANIKOWSKI , Kartik M. KEERTIKAR , Bin HU , Bin ZHONG , Tao JI , Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd.
发明人： Peter D. Williams , John A. McCauley , Christopher J. Bungard , David Jonathan Bennett , Sherman T. Waddell , Gregori J. Morriello , Lehua Chang , Michael P. Dwyer , M. Katharine Holloway , Alejandro Crespo , Xin-Jie Chu , Catherine Wiscount , H. Marie Loughran , Jesse J. Manikowski , Jurgen Schulz , Kartik M. Keertikar , Bin Hu , Bin Zhong , Tao Ji
IPC分类号： C07D513/08 , A61K31/554 , A61K45/06
CPC分类号： C07D513/08 , A61K31/554 , A61K45/06
摘要： The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
摘要翻译： 本发明涉及含有该化合物的式I药物组合物的化合物及其在抑制HIV蛋白酶，抑制HIV复制，预防HIV感染，HIV感染治疗和预防， 治疗和延迟艾滋病的发病或进展。
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