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公开(公告)号：US20170015633A1
公开(公告)日：2017-01-19
申请号：US15107233
申请日：2014-12-17
发明人： Dong Ming Shen , Melissa Egbertson , Richard Berger , XiaoXia Qian , Yimin Qian , Bart Harper , Meng Yang , Zack Zhi Qiang Guo , Vanessa L. Rada , Deping Wang , Timothy A. Cernak , Christopher Sinz , Ming Wang , Jonathan E. Wilson , Shimin Xu
IPC分类号： C07D239/36 , C07D401/12 , C07D403/04 , C07D403/06 , C07D487/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D401/06 , C07D403/12
CPC分类号： C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
摘要翻译： 公开了式（I）的嘧啶羧酰胺化合物，其可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病，药物组合物及其用途的治疗剂。
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公开(公告)号：US09815796B2
公开(公告)日：2017-11-14
申请号：US15107233
申请日：2014-12-17
发明人： Dong Ming Shen , Melissa Egbertson , Richard Berger , XiaoXia Qian , Yimin Qian , Bart Harper , Meng Yang , Zack Zhiqiang Guo , Vanessa L. Rada , Deping Wang , Timothy A. Cernak , Christopher Sinz , Ming Wang , Jonathan E. Wilson , Shimin Xu
IPC分类号： C07D239/36 , C07D401/12 , C07D401/06 , C07D403/04 , C07D403/14 , C07D487/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D403/12 , C07D403/06
CPC分类号： C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
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公开(公告)号：US10285989B2
公开(公告)日：2019-05-14
申请号：US15573858
申请日：2016-05-10
发明人： Dong-Ming Shen , Deping Wang , XiaoXia Qian , Bart Harper , Meng Yang , Yingjian Bo
IPC分类号： C07D403/12 , A61K31/513 , C07D401/12 , C07D403/04 , C07D405/12 , C07D239/38 , C07D239/42 , C07D239/52 , C07D487/04 , A61P25/28 , A61P25/22 , A61P25/18 , A61P25/16 , A61P25/06
摘要： The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：US20180256575A1
公开(公告)日：2018-09-13
申请号：US15573858
申请日：2016-05-10
发明人： Dong-Ming Shen , Deping Wang , XiaoXia Qian , Bart Harper , Meng Yang , Yingjian Bo
CPC分类号： A61K31/513 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , C07D239/38 , C07D239/42 , C07D239/52 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D487/04
摘要： The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.
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