公开(公告)号：US20240287022A1

公开(公告)日：2024-08-29

申请号：US18569352

申请日：2022-06-23

申请人： Merck Sharp & Dohme LLC

发明人： BRANDON D. CASH ,  GEORGE MADALIN GIAMBASU ,  ANDREW M. HAIDLE ,  BRETT A. HOPKINS ,  MATTHEW A. LARSEN ,  CHARLES A. LESBURG ,  PING LIU ,  RYAN QUIROZ ,  SULAGNA SANYAL ,  CATHERINE M. WHITE ,  XIN YAN ,  XIAO MEI ZHENG

IPC分类号： C07D401/06 ,  A61K31/4375 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/497 ,  A61K31/498 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/538 ,  A61K31/5383 ,  C07D215/227 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D471/06 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D401/06 ,  A61K31/4375 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/497 ,  A61K31/498 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/538 ,  A61K31/5383 ,  C07D215/227 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D471/06 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

摘要： Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof wherein A, E, U, X, Y, Z, R1, R2 and n are as defined herein. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases. Also provided herein are pharmaceutical compositions comprising the compounds of the invention, or their pharmaceutically acceptable salts, and a pharmaceutically acceptable carrier and methods of treatment with the compounds of the invention.