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1.发明授权公开(公告)号：US11970479B2
公开(公告)日：2024-04-30
申请号：US17286591
申请日：2019-10-24
发明人： John J. Acton, III , Melissa Egbertson , Xiaolei Gao , Scott T. Harrison , Timothy J. Henderson , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , James Mulhearn , Vanessa L. Rada , Jeffrey W. Schubert , Oleg B. Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang , Jianming Bao , Chunsing Li
IPC分类号： C07D401/14 , C07D405/14
CPC分类号： C07D401/14 , C07D405/14
摘要： The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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2.发明授权公开(公告)号：US11339156B2
公开(公告)日：2022-05-24
申请号：US16621953
申请日：2018-06-22
发明人： John J. Acton, III , Jianming Bao , Qiaolin Deng , Melissa Egbertson , Ronald Ferguson, II , Xiaolei Gao , Scott Timothy Harrison , Timothy J. Henderson , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Meng Na , Michael T. Rudd , Oleg B. Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang , Takao Suzuki
IPC分类号： C07D471/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D417/14
摘要： The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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3.发明申请公开(公告)号：US20210395224A1
公开(公告)日：2021-12-23
申请号：US17286591
申请日：2019-10-24
发明人： John J. Acton, III , Melissa Egbertson , Xiaolei Gao , Scott T. Harrison , Timothy J. Henderson , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , James Mulhearn , Vanessa L. Rada , Jeffrey W. Schubert , Oleg B. Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang , Jianming Bao , Chunsing Li
IPC分类号： C07D401/14 , C07D405/14
摘要： The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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公开(公告)号：US20240239788A1
公开(公告)日：2024-07-18
申请号：US18555640
申请日：2022-04-15
发明人： David L. Sloman , Gianni Chessari , Patrick Schöpf , Steven Howard , Yuichi Kawai , Kazuaki Shibata , Hiroki Asakura , Takao Uno , Takeshi Sagara , Masayuki Nakamura , Yu Kobayakawa , David Jonathan Bennett , Indu Bharathan , Thomas H. Graham , Yongxin Han , Zahid Hussain , Xiaoshen Ma , Mihir Mandal , Ryan D. Otte , Anandan Palani , Uma Swaminathan , Mycah Uehling , Yingchun Ye , Ryan Chau , Alec H. Christian , Symon Gathiaka , Timothy J. Henderson , Elisabeth T. Hennessy , Andrew J. Hoover , Shuhei Kawamura , Igri Kolaj , Thomas W. Lyons , Matthew J. Mitcheltree , Aaron Sather
IPC分类号： C07D451/06 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D471/08 , C07D519/00
CPC分类号： C07D451/06 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D471/08 , C07D519/00
摘要： Compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.
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