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1.发明授权公开(公告)号：US11339156B2
公开(公告)日：2022-05-24
申请号：US16621953
申请日：2018-06-22
发明人： John J. Acton, III , Jianming Bao , Qiaolin Deng , Melissa Egbertson , Ronald Ferguson, II , Xiaolei Gao , Scott Timothy Harrison , Timothy J. Henderson , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Meng Na , Michael T. Rudd , Oleg B. Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang , Takao Suzuki
IPC分类号： C07D471/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D417/14
摘要： The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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2.发明授权公开(公告)号：US11149036B2
公开(公告)日：2021-10-19
申请号：US16621959
申请日：2018-06-22
申请人： John J. Acton, III , Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd. , Jianming Bao , Qiaolin Deng , Melissa Egbertson , Ronald Ferguson, II , Xiaolei Gao , Scott Timothy Harrison , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , Meng Na , Michael T. Rudd , Oleg Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang
发明人： John J. Acton, III , Jianming Bao , Qiaolin Deng , Melissa Egbertson , Ronald Ferguson, II , Xiaolei Gao , Scott Timothy Harrison , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , Meng Na , Michael T. Rudd , Oleg Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang
IPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D491/048 , C07D498/04
摘要： The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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3.发明授权公开(公告)号：US10933056B2
公开(公告)日：2021-03-02
申请号：US16674546
申请日：2019-11-05
发明人： John J. Acton, III , Jianming Bao , Melissa Egbertson , Xiaolei Gao , Scott T. Harrison , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , Michael T. Rudd , Oleg B. Selyutin , David M. Tellers , Ling Tong , Jenny Miu-Chun Wai
IPC分类号： C07D401/14 , C07D405/14 , C07D471/04 , A61K31/4439 , A61P25/28 , A61P25/18 , A61P25/16 , A61K31/437
摘要： The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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4.发明申请公开(公告)号：US20210395224A1
公开(公告)日：2021-12-23
申请号：US17286591
申请日：2019-10-24
发明人： John J. Acton, III , Melissa Egbertson , Xiaolei Gao , Scott T. Harrison , Timothy J. Henderson , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , James Mulhearn , Vanessa L. Rada , Jeffrey W. Schubert , Oleg B. Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang , Jianming Bao , Chunsing Li
IPC分类号： C07D401/14 , C07D405/14
摘要： The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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5.发明授权公开(公告)号：US11970479B2
公开(公告)日：2024-04-30
申请号：US17286591
申请日：2019-10-24
发明人： John J. Acton, III , Melissa Egbertson , Xiaolei Gao , Scott T. Harrison , Timothy J. Henderson , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , James Mulhearn , Vanessa L. Rada , Jeffrey W. Schubert , Oleg B. Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang , Jianming Bao , Chunsing Li
IPC分类号： C07D401/14 , C07D405/14
CPC分类号： C07D401/14 , C07D405/14
摘要： The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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6.发明申请公开(公告)号：US20190000824A1
公开(公告)日：2019-01-03
申请号：US16062500
申请日：2016-12-19
发明人： John J. Acton, III , Jianming Bao , Melissa Egbertson , Xiaolei Gao , Scott T. Harrison , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , Michael T. Rudd , Oleg B. Selyutin , David M. Tellers , Ling Tong , Jenny Miu-Chun Wai
IPC分类号： A61K31/4439 , A61K31/437 , A61P25/16 , A61P25/18 , A61P25/28
CPC分类号： A61K31/4439 , A61K31/437 , A61P25/16 , A61P25/18 , A61P25/28 , C07D401/14 , C07D405/14 , C07D471/04
摘要： The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine 5 receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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7.发明授权Heterocycle-substituted tetracyclic compounds and methods of use thereof for the treatment of viral diseases 有权杂环取代的四环化合物及其用于治疗病毒性疾病的方法公开(公告)号：US09555038B2
公开(公告)日：2017-01-31
申请号：US14761256
申请日：2013-12-31
发明人： Wensheng Yu , Ling Tong , Joseph A. Kozlowski , Oleg Selyutin , Lei Chen , Jae-Hun Kim , Deyou Sha , Razia Rizvi , Bandarpalle Shankar
IPC分类号： C07D498/04 , C07D513/04 , A61K31/5365 , A61K45/06 , A61K31/4985 , A61K31/7056 , A61K31/7072
CPC分类号： A61K31/5365 , A61K31/4985 , A61K31/7056 , A61K31/7072 , A61K45/06 , C07D498/04 , C07D513/04 , Y02A50/385 , Y02A50/389 , A61K2300/00
摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的新型杂环取代的四环化合物：（I）及其药学上可接受的盐，其中A，A'，R 2 R3，R4和R如本文所定义。 本发明还涉及包含至少一种杂环取代的四环化合物的组合物，以及使用杂环取代的四环化合物治疗或预防患者HCV感染的方法。
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公开(公告)号：US20230391758A1
公开(公告)日：2023-12-07
申请号：US18043413
申请日：2021-09-15
发明人： Michael J. Breslin , Mark E. Fraley , Melissa C. Ford , Kristen L.G. Jones, SR. , Anthony J. Roecker , Kathy M. Schirripa , Ling Tong
IPC分类号： C07D405/12 , C07D471/04 , C07D307/85 , C07D405/06 , C07D453/02 , C07D405/14 , C07D413/12
CPC分类号： C07D405/12 , C07D471/04 , C07D307/85 , C07D405/06 , C07D453/02 , C07D405/14 , C07D413/12
摘要： The present invention relates to Compounds of Formula I: and pharmaccutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treatment or prophylaxis of lysosomal storage diseases, neurodegenerative disease, cystic disease, cancer, or a diseases or disorders associated with elevated levels of glucosylceramide (GlcCer), glucosylsphingosine (GlcSph) and/or other glucosylceramide-based glycosphingolipids (GSLs).
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![Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof](/abs-image/US/2021/11/02/US11161854B2/abs.jpg.150x150.jpg)
公开(公告)号：US11161854B2
公开(公告)日：2021-11-02
申请号：US16755172
申请日：2018-10-08
申请人： Merck Sharp & Dohme Corp. , David Annunziato Candito , Thomas H. Graham , John Acton , Ryan Wing-Kun Chau , Joanna L. Chen , J. Michael Ellis , Peter H. Fuller , Anmol Gulati , Hakan Gunaydin , Solomon Kattar , Mitchell Henry Keylor , Blair T. Lapointe , Ping Liu , Weiguo Liu , Joey L. Methot , Santhosh F. Neelamkavil , Vladimir Simov , Ling Tong , Harold B. Wood
发明人： David Annunziato Candito , Thomas H. Graham , John Acton , Ryan Wing-Kun Chau , Joanna L. Chen , J. Michael Ellis , Peter H. Fuller , Anmol Gulati , Hakan Gunaydin , Solomon Kattar , Mitchell Henry Keylor , Blair T. Lapointe , Ping Liu , Weiguo Liu , Joey L. Methot , Santhosh F. Neelamkavil , Vladimir Simov , Ling Tong , Harold B. Wood
IPC分类号： C07D491/10 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D487/08 , C07D498/04 , C07D498/10 , C07D519/00
摘要： The present invention is directed to substituted certain reversed indazolyl-spiro[2.2]pentane-carbonitrile derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
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10.发明授权公开(公告)号：US10981902B2
公开(公告)日：2021-04-20
申请号：US16621943
申请日：2018-06-22
发明人： Jianming Bao , Timothy J. Henderson , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Meng Na , Michael T. Rudd , David M. Tellers , Ling Tong
IPC分类号： C07D413/14 , C07D471/04 , C07D487/04
摘要： The present invention is directed to 5-(pyridine-3-yl)oxaxole compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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