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公开(公告)号:US09815796B2
公开(公告)日:2017-11-14
申请号:US15107233
申请日:2014-12-17
发明人: Dong Ming Shen , Melissa Egbertson , Richard Berger , XiaoXia Qian , Yimin Qian , Bart Harper , Meng Yang , Zack Zhiqiang Guo , Vanessa L. Rada , Deping Wang , Timothy A. Cernak , Christopher Sinz , Ming Wang , Jonathan E. Wilson , Shimin Xu
IPC分类号: C07D239/36 , C07D401/12 , C07D401/06 , C07D403/04 , C07D403/14 , C07D487/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D403/12 , C07D403/06
CPC分类号: C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
摘要: Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
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公开(公告)号:US20170015633A1
公开(公告)日:2017-01-19
申请号:US15107233
申请日:2014-12-17
发明人: Dong Ming Shen , Melissa Egbertson , Richard Berger , XiaoXia Qian , Yimin Qian , Bart Harper , Meng Yang , Zack Zhi Qiang Guo , Vanessa L. Rada , Deping Wang , Timothy A. Cernak , Christopher Sinz , Ming Wang , Jonathan E. Wilson , Shimin Xu
IPC分类号: C07D239/36 , C07D401/12 , C07D403/04 , C07D403/06 , C07D487/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D401/06 , C07D403/12
CPC分类号: C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
摘要: Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
摘要翻译: 公开了式(I)的嘧啶羧酰胺化合物,其可用作治疗与磷酸二酯酶2(PDE2)相关的中枢神经系统疾病,药物组合物及其用途的治疗剂。
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3.
公开(公告)号:US20210395224A1
公开(公告)日:2021-12-23
申请号:US17286591
申请日:2019-10-24
发明人: John J. Acton, III , Melissa Egbertson , Xiaolei Gao , Scott T. Harrison , Timothy J. Henderson , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , James Mulhearn , Vanessa L. Rada , Jeffrey W. Schubert , Oleg B. Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang , Jianming Bao , Chunsing Li
IPC分类号: C07D401/14 , C07D405/14
摘要: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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公开(公告)号:US20210070745A1
公开(公告)日:2021-03-11
申请号:US17049653
申请日:2019-04-29
发明人: Brendan M. Crowley , Brian T. Campbell , Harry R. Chobanian , James I. Fells , Deodial G. Guiadeen , Thomas J. Greshock , Kenneth J. Leavitt , Vanessa L. Rada , Ian M. Bell
IPC分类号: C07D413/14 , C07D413/08
摘要: The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation (I).
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5.
公开(公告)号:US20210196734A1
公开(公告)日:2021-07-01
申请号:US17193550
申请日:2021-03-05
发明人: Brendan M. Crowley , Ian M. Bell , Andrew John Harvey , Brian T. Campbell , Thomas J. Greshock , Vanessa L. Rada
IPC分类号: A61K31/695 , A61K31/198 , A61K31/4164 , A61K31/4196 , A61K31/4245 , A61K31/4418 , A61K31/4439 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/34 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D271/06 , C07D401/04 , C07D413/04 , C07F7/08
摘要: The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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公开(公告)号:US20180030007A1
公开(公告)日:2018-02-01
申请号:US15727982
申请日:2017-10-09
发明人: Brendan M. Crowley , Brian T. Campbell , Joseph L. Duffy , Thomas J. Greshock , Deodial G. Guiadeen , Andrew John Harvey , Belinda C. Huff , Kenneth J. Leavitt , Vanessa L. Rada , John M. Sanders , William D. Shipe , Linda M. Suen , Ian M. Bell
IPC分类号: C07D285/12 , A61K31/415 , C07D271/107 , C07D271/06 , C07D263/32 , C07D261/08 , C07D249/04 , C07D231/12 , A61K31/433 , A61K31/426 , A61K31/4245 , A61K31/421 , A61K31/42 , A61K31/4192 , C07D277/26 , C07D285/08
CPC分类号: C07D285/12 , A61K31/415 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , C07D231/12 , C07D233/64 , C07D249/04 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D285/08 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D495/04
摘要: The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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公开(公告)号:US09840481B2
公开(公告)日:2017-12-12
申请号:US15463336
申请日:2017-03-20
发明人: Brendan M. Crowley , Brian T. Campbell , Joseph L. Duffy , Thomas J. Greshock , Deodial G. Guiadeen , Andrew John Harvey , Belinda C. Huff , Kenneth J. Leavitt , Vanessa L. Rada , John M. Sanders , William D. Shipe , Linda M. Suen , Ian M. Bell
IPC分类号: C07D285/12 , C07D231/12 , C07D249/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/07 , C07D277/26 , C07D285/08 , A61K31/4245 , A61K31/433 , C07D271/107 , A61K31/421 , A61K31/42 , A61K31/4192 , A61K31/415 , A61K31/426
CPC分类号: C07D285/12 , A61K31/415 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , C07D231/12 , C07D233/64 , C07D249/04 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D285/08 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D495/04
摘要: The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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8.
公开(公告)号:US11026958B2
公开(公告)日:2021-06-08
申请号:US16345997
申请日:2017-10-30
发明人: Brendan M. Crowley , Ian M. Bell , Andrew John Harvey , Brian T. Campbell , Thomas J. Greshock , Vanessa L. Rada
IPC分类号: A61K31/695 , A61K31/198 , C07D213/34 , C07D413/04 , C07D239/26 , C07D401/04 , C07D271/06 , C07D233/64 , C07D249/08 , A61K31/4418 , A61K31/5377 , A61K31/505 , A61K31/4439 , A61K31/4245 , A61K31/506 , A61K31/50 , A61K31/4965 , C07D237/08 , C07D241/12 , C07F7/08 , A61K31/4196 , A61K31/4164 , A61K45/06
摘要: The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.
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公开(公告)号:US10239849B2
公开(公告)日:2019-03-26
申请号:US15774157
申请日:2016-11-07
申请人: Merck Sharp & Dohme Corp. , Michael T. Rudd , Edward J. Brnardic , Yuntae Kim , Robert S. Meissner , Vanessa L. Rada , Shawn J. Stachel , Celina V. Zerbinatti
发明人: Michael T. Rudd , Edward J. Brnardic , Yuntae Kim , Robert S. Meissner , Vanessa L. Rada , Shawn J. Stachel , Celina V. Zerbinatti
IPC分类号: C07D243/08 , C07D295/16 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D487/08 , C07D513/04 , A61P25/18 , A61P25/16 , A61P25/28 , A61P3/10
摘要: In its many embodiments, the present invention provides substituted cyanopyridine containing compounds of the Formula (I): and acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, Q, and the moiety are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.
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公开(公告)号:US11332463B2
公开(公告)日:2022-05-17
申请号:US17049653
申请日:2019-04-29
发明人: Brendan M. Crowley , Brian T. Campbell , Harry R. Chobanian , James I. Fells , Deodial G. Guiadeen , Thomas J. Greshock , Kenneth J. Leavitt , Vanessa L. Rada , Ian M. Bell
IPC分类号: C07D413/08 , C07D413/14 , C07D417/08 , C07D417/14 , C07D403/08 , C07D513/04 , C07D471/04 , C07D487/04 , A61P25/00
摘要: The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation (I).
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