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1.发明授权Recombinant viruses comprising the membrane-proximal domain of VSV G protein 失效包含VSV G蛋白的膜近端结构域的重组病毒公开(公告)号：US07994295B2
公开(公告)日：2011-08-09
申请号：US10327673
申请日：2002-12-23
CPC分类号： C07K14/005 , C07K2319/00 , C12N15/86 , C12N2760/18022 , C12N2760/20222 , C12N2760/20243 , C12N2810/855 , C12N2810/859 , C12N2840/20
摘要： Recombinant viruses, isolated nucleic acids and methods of generating same encoding for a Rhabdoviral G stem polypeptide are disclosed. Methods, compounds and compositions for target cell fusion potentiation mediated by Rhabdoviral G stem polypeptides, and applications of same are provided.
摘要翻译： 公开了重组病毒，分离的核酸和产生Rhabdoviral G stem多肽的相同编码方法。 提供了由Rhabdoviral G stem多肽介导的靶细胞融合增强的方法，化合物和组合物及其应用。
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2.发明申请Recombinant viruses comprising the membrane-proximal domain of VSV G protein 失效包含VSV G蛋白的膜近端结构域的重组病毒公开(公告)号：US20100167377A1
公开(公告)日：2010-07-01
申请号：US10327673
申请日：2002-12-23
CPC分类号： C07K14/005 , C07K2319/00 , C12N15/86 , C12N2760/18022 , C12N2760/20222 , C12N2760/20243 , C12N2810/855 , C12N2810/859 , C12N2840/20
摘要： Recombinant viruses, isolated nucleic acids and methods of generating same encoding for a Rhabdoviral G stem polypeptide are disclosed. Methods, compounds and compositions for target cell fusion potentiation mediated by Rhabdoviral G stem polypeptides, and applications of same are provided.
摘要翻译： 公开了重组病毒，分离的核酸和产生Rhabdoviral G stem多肽的相同编码方法。 提供了由Rhabdoviral G stem多肽介导的靶细胞融合增强的方法，化合物和组合物及其应用。
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公开(公告)号：US06497873B1
公开(公告)日：2002-12-24
申请号：US09217967
申请日：1998-12-22
IPC分类号： A01N6300
CPC分类号： C12N15/86 , C07K14/005 , C07K2319/00 , C12N2760/18022 , C12N2760/20222 , C12N2760/20243 , C12N2810/855 , C12N2810/859 , C12N2840/20
摘要： This invention relates to a composition comprising a recombinant or genetically engineered Rhabdovirus that expresses a Fusion Protein, such as the F protein of the Paramyxovirus SV5 strain. This recombinant Rhabdovirus may express other non-Rhabdovirus attachment proteins and/or an enhancer protein. The invention also relates to methods of making recombinant Rhabdoviruses which express an F Protein. These recombinant compositions can be used for purposes of research, as well as for diagnostic and therapeutic compositions for treatment of diseases.
摘要翻译： 本发明涉及包含表达融合蛋白的重组或遗传工程化的Rhabdovirus的组合物，例如副粘病毒SV5株的F蛋白。 该重组Rhabdovirus可以表达其他非Rhabdovirus附着蛋白和/或增强子蛋白。 本发明还涉及制备表达F蛋白的重组杆状病毒的方法。 这些重组组合物可用于研究目的，以及用于治疗疾病的诊断和治疗组合物。
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公开(公告)号：US20170232253A1
公开(公告)日：2017-08-17
申请号：US15044972
申请日：2016-02-16
申请人： Marcy C. Purnell , Michael A. Whitt
发明人： Marcy C. Purnell , Michael A. Whitt
CPC分类号： A61N1/20 , A61K33/14 , A61N1/0472
摘要： Disclosed are methods and devices utilizing bioelectrodynamics for the therapeutic treatment of disorders in a subject in need thereof with an electric field or electromagnetic field therapy. The methods and devices provide an inhibitory effect on growth of cancer cells that are exposed to an electromagnetic field generated by a CETS unit. Cancer cells may arrest proliferation and enter apoptosis by activation of the unfolded protein response (UPR), TNF/TRAIL, and p53 oncogene activation. The methods and devices may be used to enhance wound healing with exposure to an electromagnetic field generated by a CETS unit. Noncancerous cells may show a significant increase in cell migration with no activation of apoptosis pathways.
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