公开(公告)号：US20050143713A1

公开(公告)日：2005-06-30

申请号：US11071792

申请日：2005-03-03

申请人： Michael Delmore ,  Patrick Fleming ,  Douglas Huntley ,  Jamieson Keister ,  Cristina Thomas ,  Richard Ferber

发明人： Michael Delmore ,  Patrick Fleming ,  Douglas Huntley ,  Jamieson Keister ,  Cristina Thomas ,  Richard Ferber

IPC分类号： A61M37/00 ,  A61M31/00

CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150969 ,  A61B5/150984 ,  A61B2562/0295 ,  A61M2037/0007 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0053

摘要： Microneedle arrays, methods of manufacturing microneedles and methods of using microneedle arrays. The microneedles in the microneedle arrays may be in the form of tapered structures that include at least one channel formed in the outside surface of each microneedle. The microneedles may have bases that are elongated in one direction. The channels in microneedles with elongated bases may extend from one of the ends of the elongated bases towards the tips of the microneedles. The channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles. The microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue.

公开(公告)号：US20050261631A1

公开(公告)日：2005-11-24

申请号：US10621620

申请日：2003-07-17

申请人： Graham Clarke ,  Michael Delmore ,  Michael Domroese ,  Richard Ferber ,  Jay Jacobs ,  Jamieson Keister ,  Franklyn Frederickson

发明人： Graham Clarke ,  Michael Delmore ,  Michael Domroese ,  Richard Ferber ,  Jay Jacobs ,  Jamieson Keister ,  Franklyn Frederickson

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61M5/00 ,  A61M37/00

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K9/7023 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2205/0244

摘要： Microneedle devices with microneedles having a truncated tapered shape are disclosed. The microneedles of microneedle devices may also have a controlled aspect ratio. Microneedle delivery apparatus are disclosed that include drivers designed to deliver microneedles at velocities that may enhance perforation of the stratum corneum while limiting the sensation of pain experienced at the delivery site.

摘要翻译： 公开了具有截头锥形形状的具有微针的微针装置。 微针装置的微针也可以具有受控的纵横比。 公开了一种微针输送装置，其包括设计成以可以增强角质层穿孔的速度递送微针的驱动器，同时限制在输送部位经历的疼痛的感觉。

公开(公告)号：US20050187521A1

公开(公告)日：2005-08-25

申请号：US11111428

申请日：2005-04-21

申请人： Patrick Fleming ,  Michael Delmore ,  Luther Erickson ,  Richard Ferber

发明人： Patrick Fleming ,  Michael Delmore ,  Luther Erickson ,  Richard Ferber

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/15 ,  A61B5/157 ,  A61M37/00 ,  A61M5/00

CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150572 ,  A61B5/150717 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/157 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053

摘要： Microneedle devices and methods of manufacturing the microneedle devices. The microneedle devices include microneedles protruding from a substrate, with the microneedles piercing a cover placed over the substrate surface from which the microneedles protrude. The cover and the microneedle substrate together define a capillary volume in fluid communication with the base of each microneedle. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue. Manufacturing methods may include simultaneous application of pressure and ultrasonic energy when piercing the cover with the microneedles.