公开(公告)号：US20190216363A1

公开(公告)日：2019-07-18

申请号：US16155480

申请日：2018-10-09

申请人： Theranos IP Company, LLC

发明人： Elizabeth A. Holmes ,  Shaunak Roy ,  John Howard ,  Chengwang Wang

IPC分类号： A61B5/07 ,  A61B5/151 ,  A61B5/15 ,  A61B5/00 ,  A61B5/157 ,  A61B5/145 ,  B01L3/00 ,  A61M37/00 ,  A61B5/1477 ,  A61B5/1473 ,  A61B5/1455

CPC分类号： A61B5/073 ,  A61B5/0024 ,  A61B5/0031 ,  A61B5/1411 ,  A61B5/145 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1473 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150251 ,  A61B5/150282 ,  A61B5/150343 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/15087 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/15119 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/1519 ,  A61B5/157 ,  A61B5/417 ,  A61B5/4238 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/6833 ,  A61B5/685 ,  A61B5/6865 ,  A61B5/7282 ,  A61B2560/0412 ,  A61M5/14276 ,  A61M37/0015 ,  A61M2005/14513 ,  A61M2005/1726 ,  A61M2037/0023 ,  A61M2205/0244 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/50 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/10 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0472 ,  B01L2400/0487 ,  G01N2035/00158

摘要： The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

公开(公告)号：US20180344230A1

公开(公告)日：2018-12-06

申请号：US15994831

申请日：2018-05-31

申请人： Life Patch International

发明人： Brigitte Chau Phan ,  Andrew Atilla Pal ,  Ramoncito M. Valencia ,  Donald Bollella

IPC分类号： A61B5/15 ,  G01N33/52 ,  A61B5/00 ,  B82Y15/00 ,  B82Y30/00 ,  A61B5/11 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/151 ,  A61B5/157 ,  B01L3/00

CPC分类号： A61B5/150969 ,  A61B5/0002 ,  A61B5/0022 ,  A61B5/1112 ,  A61B5/1411 ,  A61B5/145 ,  A61B5/14514 ,  A61B5/14521 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/157 ,  A61B5/4839 ,  A61B5/681 ,  A61B5/6833 ,  A61B5/72 ,  A61B5/7475 ,  A61B2505/07 ,  A61B2560/0214 ,  A61B2560/0412 ,  A61B2562/028 ,  A61B2562/0285 ,  A61B2562/0295 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/143 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/049 ,  B01L2400/0655 ,  B01L2400/0677 ,  B82Y15/00 ,  B82Y30/00 ,  G01N33/528

摘要： Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by trans-dermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power.

公开(公告)号：US20180070869A1

公开(公告)日：2018-03-15

申请号：US15453920

申请日：2017-03-09

申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

发明人： Mihai Adrian Ionescu ,  Hoël Guerin ,  Erick García Cordero ,  Francesco Bellando

IPC分类号： A61B5/1477 ,  G01N27/12 ,  A61B5/15 ,  A61B10/00

CPC分类号： A61B5/1477 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150969 ,  A61B5/157 ,  A61B5/4266 ,  A61B10/0045 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/028 ,  A61B2562/0285 ,  A61B2562/0295 ,  G01N27/122 ,  G01N27/4145 ,  G01N33/54366

摘要： An on-body wearable bio-fluid collection and sensing device including an interface or interface surface comprising at least one biocompatible material for contacting a bodily part; at least one inlet for receiving the bio-fluid, at least one outlet for evacuating the bio-fluid, a plurality of semiconductor sensors configured to analyze the received bio-fluid, at least one reference electrode for biasing a bio-fluid gate of at least one of the semiconductor sensors, and at least one micro-fluidic or nano-fluidic channel in fluid communication with the at least one inlet, the at least one outlet and the at least one reference electrode; the at least one micro-fluidic or nano-fluidic channel includes the plurality of semiconductor sensors.

公开(公告)号：US20180021219A1

公开(公告)日：2018-01-25

申请号：US15653816

申请日：2017-07-19

申请人： Sysmex Corporation

发明人： Ayato TAGAWA ,  Junko KOJIMA ,  Nobuyasu HORI ,  Kenji AKAMA ,  Masaya OKADA ,  Kunpeng CAI ,  Samiko HOSOYA ,  Shigeki IWANAGA

IPC分类号： A61J1/14 ,  A61J1/16 ,  A61J1/05

CPC分类号： A61J1/1475 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150748 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/15105 ,  A61B5/155 ,  A61J1/05 ,  A61J1/165 ,  B01L3/502715 ,  B01L3/5082 ,  B01L2200/0684 ,  B01L2300/024 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2300/1822 ,  B01L2300/1894

摘要： A blood collection device including a flow path to flow blood by capillary action capable of collecting a large amount of blood is provided. The blood collection device includes an introduction inlet 23 for introducing the blood of the subject M, a substrate 20 connected to the introduction inlet 23 and including a flow path 25 to flow the blood by capillary action, and a cooling body 30 for cooling the flow path 25.

公开(公告)号：US09839384B2

公开(公告)日：2017-12-12

申请号：US14743867

申请日：2015-06-18

申请人： Intuity Medical, Inc.

发明人： Raul Escutia ,  Jeffrey L. Emery ,  Craig M. Litherland

IPC分类号： A61B5/151 ,  A61B5/15 ,  A61B5/157 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  G01N21/03 ,  A61B5/1468 ,  G01N1/14 ,  G01N21/77 ,  G01N27/416

CPC分类号： A61B5/150984 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150167 ,  A61B5/150229 ,  A61B5/150343 ,  A61B5/150389 ,  A61B5/150396 ,  A61B5/150412 ,  A61B5/150946 ,  A61B5/150954 ,  A61B5/150969 ,  A61B5/151 ,  A61B5/15111 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15148 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15186 ,  A61B5/155 ,  A61B5/157 ,  A61B5/681 ,  A61B5/6824 ,  A61B5/6828 ,  A61B2560/0443 ,  A61B2560/0462 ,  G01N1/14 ,  G01N21/0303 ,  G01N21/77 ,  G01N27/416

摘要： An arrangement for producing a sample of body fluid from an opening created in a skin surface at a sampling site including a cartridge with a plurality of compartments and a plurality of sampling sites, and a detector assembly. Each sampling site includes a skin-penetration member having a first end configured to pierce the surface of the skin and an inner lumen in communication with the first end, a spring actuator operatively associated with the skin-penetration member, and a needle hub connecting the skin-penetration member and the spring actuator. The needle hub includes a reagent pad and the spring actuator is configured to drive the skin-penetration member to form the wound opening. Each compartment at least partially encloses the skin-penetration member, the spring actuator, and the needle hub of a respective sampling site.

公开(公告)号：US09808377B2

公开(公告)日：2017-11-07

申请号：US14063489

申请日：2013-10-25

申请人： Sandip Mitra ,  Paul Ernest Charles Brenchley ,  Rein Vincent Ulijn

发明人： Sandip Mitra ,  Paul Ernest Charles Brenchley ,  Rein Vincent Ulijn

IPC分类号： A61M1/00 ,  A61F13/15 ,  A61B5/145 ,  A61B5/151 ,  A61B5/00 ,  A61M1/14 ,  A61M37/00 ,  A61B5/15 ,  A61B5/1486

CPC分类号： A61F13/15203 ,  A61B5/14514 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150091 ,  A61B5/150358 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/412 ,  A61M1/0023 ,  A61M1/14 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0061

摘要： A fluid extraction or filtration device for removing fluid from a body, the device comprising an array of microneedles for contacting fluid in said body and an absorbent gel matrix in fluid communication with said array of microneedles. There is further provided a combined fluid extraction and sampling device and methods employing the device(s), for example in determining the level of a target species in a sample of fluid, transdermal dialysis and renal replacement therapy. There is further provided an absorbent gel matrix for use in the treatment of uraemia and a haemodialysis filter comprising an absorbent gel matrix. Use of such a matrix is described in the context of methods including haemodialysis, transdermal dialysis and gastrointestinal dialysis.

公开(公告)号：US09730624B2

公开(公告)日：2017-08-15

申请号：US14328892

申请日：2014-07-11

申请人： Seventh Sense Biosystems, Inc.

发明人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse ,  Howard Bernstein ,  Douglas A. Levinson

IPC分类号： A61B5/00 ,  A61B5/15 ,  A61B5/151 ,  A61B10/00 ,  A61M37/00 ,  A61B5/154 ,  G06F19/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1486

CPC分类号： A61B5/150374 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15144 ,  A61B5/154 ,  A61B5/411 ,  A61B5/685 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/007 ,  A61B2010/008 ,  A61M37/0015 ,  G06F19/00 ,  G16H10/40

摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

公开(公告)号：US20170215790A1

公开(公告)日：2017-08-03

申请号：US15290217

申请日：2016-10-11

申请人： Seventh Sense Biosystems, Inc.

发明人： Douglas A. Levinson ,  Howard Bernstein

IPC分类号： A61B5/00 ,  A61B5/11 ,  A61B5/15 ,  G06F19/00 ,  A61B5/145

CPC分类号： A61B5/4833 ,  A61B5/1112 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14514 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150175 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150809 ,  A61B5/150824 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15113 ,  A61B5/15125 ,  A61B5/15142 ,  A61B5/154 ,  A61B5/157 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/6824 ,  A61B10/0045 ,  A61B2010/0009 ,  A61B2010/008 ,  A61M5/1723 ,  A61M37/0015 ,  A61M2037/0023 ,  G06F19/3418 ,  G06F19/3456 ,  G06F19/3468 ,  G06Q20/10 ,  G06Q30/02 ,  G06Q30/0207 ,  G06Q50/22 ,  G16H40/63 ,  Y02A90/22 ,  Y02A90/26

摘要： The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.

公开(公告)号：US20170119289A1

公开(公告)日：2017-05-04

申请号：US15334862

申请日：2016-10-26

申请人： Seiko Epson Corporation

发明人： Satomi YOSHIOKA ,  Hiroshi YAGI

IPC分类号： A61B5/145 ,  A61B5/1455

CPC分类号： A61B5/14517 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150969 ,  A61B10/0064

摘要： A sweat collection device as a fluid collection device includes a collection section which collects sweat, and a discharge section which discharges the sweat collected by the collection section from the collection section. Further, the sweat collection device is attached to the skin as an adherend, and the collection section is configured to be hermetically sealed by attaching the sweat collection device to the skin. Further, the sweat collection device includes a transfer section which connects the collection section and the discharge section to each other. Further, the sweat collection device includes a gel-like response section which is placed on any of the collection section, the transfer section, and the discharge section, and responds to lactic acid contained in sweat.

公开(公告)号：US20170095191A1

公开(公告)日：2017-04-06

申请号：US15378711

申请日：2016-12-14

申请人： Becton, Dickinson and Company

发明人： Gary D. Fletcher ,  Craig A. Gelfand ,  Daniel J. Marchiarullo ,  C. Mark Newby ,  Ashley Rachel Rothenberg

IPC分类号： A61B5/15 ,  G01N1/34 ,  B01L3/00 ,  G01N33/49 ,  A61B5/151 ,  A61B5/157

CPC分类号： A61B5/150213 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150267 ,  A61B5/150305 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/150412 ,  A61B5/150435 ,  A61B5/150442 ,  A61B5/150748 ,  A61B5/150755 ,  A61B5/150778 ,  A61B5/150969 ,  A61B5/151 ,  A61B5/15101 ,  A61B5/15105 ,  A61B5/15144 ,  A61B5/15198 ,  A61B5/157 ,  A61M1/34 ,  A61M1/36 ,  B01L3/502 ,  B01L3/5021 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2400/0478 ,  B04B7/08 ,  G01N1/28 ,  G01N1/34 ,  G01N1/4005 ,  G01N1/4077 ,  G01N33/491 ,  G01N2001/4016 ,  G01N2001/4088

摘要： A blood separation and testing system for a blood sample is disclosed. The blood separation and testing system includes a blood sampling transfer device adapted to receive a blood sample, a blood separation device, and a blood testing device. The blood separation device is adapted to receive a portion of the blood sampling transfer device such that with the blood sampling transfer device received within the blood separation device and a rotational force applied to the blood sampling transfer device, a plasma portion of the blood sample is separated from a cellular portion of the blood sample. The blood testing device is adapted to receive a portion of the blood sampling transfer device to analyze the plasma portion of the blood sample and obtain test results.