公开(公告)号：US06406548B1

公开(公告)日：2002-06-18

申请号：US09618830

申请日：2000-07-18

申请人： Michael Donovan ,  Robert P. Jansen ,  Richard C. Reisig ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

发明人： Michael Donovan ,  Robert P. Jansen ,  Richard C. Reisig ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

IPC分类号： C13D316

CPC分类号： C13B10/00 ,  C13B20/00 ,  C13B20/165

摘要： A process for producing sugar from cane includes the step of filtering a sucrose-containing feed juice, which has been obtained from macerated sugar cane, through a first ultrafiltration membrane that has a first molecular weight cutoff. This ultrafiltration step produces a first ultrafiltration permeate and a first ultrafiltration retentate. The first ultrafiltration permeate is filtered through a second ultrafiltration membrane that has a second molecular weight cutoff that is lower than the first molecular weight cutoff. This second ultrafiltration step produces a second ultrafiltration permeate and a second ultrafiltration retentate. The second ultrafiltration permeate is nanofiltered through a nanofiltration membrane, thereby producing a nanofiltration permeate and a nanofiltration retentate. The nanofiltration retentate has a higher concentration of sucrose on a dry solids basis than the feed juice in step (a), and can be used in evaporation and crystallization operations to produce crystals of white sugar. The process can optionally include ion exchange and/or electrodialysis purification steps, prior to or after the nanofiltration step. Recycle syrups can be treated with a chromatographic separator to remove excess invert, ash and color.

摘要翻译： 从甘蔗生产糖的方法包括通过具有第一分子量截留值的第一超滤膜过滤从浸出的甘蔗获得的含蔗糖的进料汁的步骤。 该超滤步骤产生第一超滤渗透物和第一超滤滞留物。 第一超滤渗透物通过具有低于第一分子量截止值的第二分子量截止值的第二超滤膜过滤。 该第二超滤步骤产生第二超滤渗透物和第二超滤滞留物。 第二超滤渗透物通过纳滤膜进行纳滤，从而产生纳滤膜渗透物和纳滤膜渗余物。 纳米过滤滞留物在干固体基础上具有比步骤（a）中的进料汁更高的蔗糖浓度，并且可用于蒸发和结晶操作以产生白糖晶体。 该方法可任选地包括在纳滤过程之前或之后的离子交换和/或电渗析纯化步骤。 回收糖浆可以用色谱分离器处理，以去除多余的反转，灰分和颜色。

公开(公告)号：US06440222B1

公开(公告)日：2002-08-27

申请号：US09618831

申请日：2000-07-18

申请人： Michael Donovan ,  Robert P. Jansen ,  Richard C. Reisig ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

发明人： Michael Donovan ,  Robert P. Jansen ,  Richard C. Reisig ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

IPC分类号： C13D108

CPC分类号： B01D61/142 ,  B01D61/16 ,  B01D2311/04 ,  C13B10/00 ,  C13B20/00 ,  C13B20/165 ,  B01D2311/103 ,  B01D2311/246 ,  B01D2311/2623 ,  B01D2311/268

摘要： A process for producing sugar from beets includes the step of filtering a sucrose-containing feed juice, which has been obtained from macerated sugar beets, through a first ultrafiltration membrane that has a first molecular weight cutoff. This ultrafiltration step produces a first ultrafiltration permeate and a first ultrafiltration retentate. The first ultrafiltration permeate is filtered through a second ultrafiltration membrane that has a second molecular weight cutoff that is lower than the first molecular weight cutoff. This second ultrafiltration step produces a second ultrafiltration permeate and a second ultrafiltration retentate. The second ultrafiltration permeate is nanofiltered through a nanofiltration membrane, thereby producing a nanofiltration permeate and a nanofiltration retentate. The nanofiltration retentate has a higher concentration of sucrose on a dry solids basis than the feed juice in step (a), and can be used in evaporation and crystallization operations to produce crystals of white sugar. The process can optionally include ion exchange and/or electrodialysis purification steps, prior to or after the nanofiltration step. Recycle syrups can be treated with enzyme or a chromatographic separator to remove raffinose.

摘要翻译： 从甜菜制备糖的方法包括通过具有第一分子量截留值的第一超滤膜过滤从浸出的甜菜获得的含蔗糖的进料汁的步骤。 该超滤步骤产生第一超滤渗透物和第一超滤滞留物。 第一超滤渗透物通过具有低于第一分子量截止值的第二分子量截止值的第二超滤膜过滤。 该第二超滤步骤产生第二超滤渗透物和第二超滤滞留物。 第二超滤渗透物通过纳滤膜进行纳滤，从而产生纳滤膜渗透物和纳滤膜渗余物。 纳米过滤滞留物在干固体基础上具有比步骤（a）中的进料汁更高的蔗糖浓度，并且可用于蒸发和结晶操作以产生白糖晶体。 该方法可任选地包括在纳滤过程之前或之后的离子交换和/或电渗析纯化步骤。 可以用酶或色谱分离器处理回收糖浆以除去棉子糖。

公开(公告)号：US06406547B1

公开(公告)日：2002-06-18

申请号：US09618416

申请日：2000-07-18

申请人： Michael Donovan ,  Robert P. Jansen ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

发明人： Michael Donovan ,  Robert P. Jansen ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

IPC分类号： C13D316

CPC分类号： C13B10/00 ,  C13B20/00 ,  C13B20/165

摘要： A process for producing sugar from beets includes the step of filtering a sucrose-containing feed juice, which has been obtained by diffusion from sliced sugar beets, through a first ultrafiltration membrane that has a first molecular weight cutoff. This ultrafiltration step produces a first ultrafiltration permeate and a first ultrafiltration retentate. The first ultrafiltration permeate is filtered through a second ultrafiltration membrane that has a second molecular weight cutoff that is lower than the first molecular weight cutoff. This second ultrafiltration step produces a second ultrafiltration permeate and a second ultrafiltration retentate. The second ultrafiltration permeate is nanofiltered through a nanofiltration membrane, thereby producing a nanofiltration permeate and a nanofiltration retentate. The nanofiltration retentate has a higher concentration of sucrose on a dry solids basis than the feed juice in step (a), and can be used in evaporation and crystallization operations to produce crystals of white sugar. The process can optionally include ion exchange and/or electrodialysis purification steps, prior to or after the nanofiltration step. Recycle syrups can be treated with enzyme or a chromatographic separator to remove raffinose.

摘要翻译： 从甜菜制备糖的方法包括将通过从切片的甜菜中扩散获得的含蔗糖的进料汁通过具有第一分子量截留值的第一超滤膜过滤的步骤。 该超滤步骤产生第一超滤渗透物和第一超滤滞留物。 第一超滤渗透物通过具有低于第一分子量截止值的第二分子量截止值的第二超滤膜过滤。 该第二超滤步骤产生第二超滤渗透物和第二超滤滞留物。 第二超滤渗透物通过纳滤膜进行纳滤，从而产生纳滤膜渗透物和纳滤膜渗余物。 纳米过滤滞留物在干固体基础上具有比步骤（a）中的进料汁更高的蔗糖浓度，并且可用于蒸发和结晶操作以产生白糖晶体。 该方法可任选地包括在纳滤过程之前或之后的离子交换和/或电渗析纯化步骤。 可以用酶或色谱分离器处理回收糖浆以除去棉子糖。

公开(公告)号：US06174378B1

公开(公告)日：2001-01-16

申请号：US09377232

申请日：1999-08-19

申请人： Michael Donovan ,  John C. Williams

发明人： Michael Donovan ,  John C. Williams

IPC分类号： C13D316

CPC分类号： C13B10/02 ,  A23L5/49 ,  C13B20/06 ,  C13B20/165

摘要： A process for purifying cane sugar from an aqueous composition thereof comprises the steps of (a) contacting an aqueous cane sugar feed composition with sufficient lime to increase the pH of the composition to at least about 9.5; (b) filtering the composition through a membrane having a pore size no greater than about 0.5 microns and having a molecular weight cutoff no less than about 5 kD, thereby producing a retentate and a permeate; and (c) contacting the permeate with sufficient carbon dioxide, or other materials designed to precipitate calcium and lower the pH, to adjust the pH to about 6.5-9.0. The feed composition preferably is cane juice, cane syrup, an aqueous composition of raw sugar, a cane sugar refinery stream, or a mixture of one or more such materials.

摘要翻译： 用于从其水性组合物中纯化甘蔗糖的方法包括以下步骤：（a）将蔗糖水进料组合物与足够的石灰接触以将组合物的pH增加至至少约9.5; （b）通过孔径不大于约0.5微米并且分子量截留值不低于约5kD的膜过滤组合物，从而产生渗余物和渗透物; 和（c）使渗透物与足够的二氧化碳或设计用于沉淀钙并降低pH值的其它材料接触以将pH调节至约6.5-9.0。 饲料组合物优选是甘蔗汁，甘蔗糖浆，原糖的水性组合物，蔗糖精炼料流或一种或多种这样的材料的混合物。

公开(公告)号：US08895702B2

公开(公告)日：2014-11-25

申请号：US13542805

申请日：2012-07-06

申请人： John C. Williams ,  Ulrich Rodeck ,  Joshua M. Donaldson ,  Csaba Kari

发明人： John C. Williams ,  Ulrich Rodeck ,  Joshua M. Donaldson ,  Csaba Kari

IPC分类号： C07K16/28 ,  C07K16/00 ,  C07K16/30

CPC分类号： C07K16/2863 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/33 ,  C07K2319/50

摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a cross-masked mAb heterodimer complex is provided, comprising a first masked mAb, comprising a first signal sequence, a first masking epitope sequence, a first linker that is cleavable by a protease specific to a target tissue, and a first antibody or fragment thereof; and a second masked mAb, comprising a second signal sequence, a second masking epitope sequence, a second linker that is cleavable by a protease specific to a target tissue, and a second antibody or fragment thereof.

摘要翻译： 在一个实施方案中，提供了掩蔽的单克隆抗体（mAb），由核酸序列或包含信号序列，掩蔽表位序列的氨基酸序列分子编码的mAb，可通过蛋白酶特异性的蛋白酶切割的接头序列 目标组织; 和抗体或其功能片段。 在另一个实施方案中，提供了跨屏蔽的mAb异二聚体复合物，其包含第一掩蔽的mAb，其包含第一信号序列，第一掩蔽表位序列，可被靶组织特异性的蛋白酶切割的第一接头， 抗体或其片段; 和第二掩蔽的mAb，其包含第二信号序列，第二掩蔽表位序列，可被靶组织特异性的蛋白酶切割的第二接头和第二抗体或其片段。

公开(公告)号：US4586947A

公开(公告)日：1986-05-06

申请号：US451763

申请日：1982-12-21

申请人： Patrick J. Crowley ,  John C. Williams

发明人： Patrick J. Crowley ,  John C. Williams

IPC分类号： A01N43/50 ,  A01N43/653 ,  C07D233/60 ,  C07D249/08 ,  C07D521/00

CPC分类号： C07D231/12 ,  A01N43/50 ,  A01N43/653 ,  C07D233/56 ,  C07D249/08

摘要： Compounds having the general formula (I): ##STR1## wherein Y is --CH.dbd. or .dbd.N--, R.sup.1 is alkyl, cycloalkyl optionally substituted phenyl and R.sup.2 and R.sup.3, which may be the same or different, are hydrogen, alkyl, cycloalkyl, (e.g. cyclopropyl, cyclopentyl or cyclohexyl) optionally substituted phenyl or optionally substituted benzyl, or together form an alkylene bridging group; and acid addition salts; metal complexes; ether and ester derivatives of the hydroxy groups; and stereoisomers thereof. These compounds have fungicidal and plant growth regulating properties.

摘要翻译： 具有通式（I）的化合物：其中Y是-CH =或= N-，R 1是烷基，环烷基任选取代的苯基，R 2和R 3可以相同或不同，是氢，烷基，环烷基 ，（例如环丙基，环戊基或环己基）任选取代的苯基或任选取代的苄基，或一起形成亚烷基桥基; 和酸加成盐; 金属配合物 乙醚和酯衍生物的羟基; 及其立体异构体。 这些化合物具有杀真菌和植物生长调节性质。

公开(公告)号：US4547214A

公开(公告)日：1985-10-15

申请号：US451762

申请日：1982-12-21

申请人： Patrick J. Crowley ,  John C. Williams

发明人： Patrick J. Crowley ,  John C. Williams

IPC分类号： A01N43/50 ,  A01N43/653 ,  C07D233/60 ,  C07D249/08 ,  C07D521/00 ,  A01N43/64

CPC分类号： C07D231/12 ,  A01N43/50 ,  A01N43/653 ,  C07D233/56 ,  C07D249/08

摘要： Azole compounds having the general formula (I): ##STR1## wherein Y is --CH.dbd. or .dbd.N--, R.sup.1 is alkyl, cycloalkyl or optionally substituted phenyl and R.sup.2 and R.sup.3, which may be the same or different, are hydrogen, alkyl, cycloalkyl, (e.g. cyclopropyl, cyclopentyl or cyclohexyl), optionally substituted phenyl or optionally substituted benzyl, or together form an alkylene bridging group; and acid addition salts, metal complexes, ester and ether derivatives of the hydroxy group and stereoisomers thereof. The compounds are useful as plant fungicides and for plant growth regulation.

摘要翻译： 具有通式（I）的唑类化合物：其中Y为-CH =或= N-，R 1为烷基，环烷基或任选取代的苯基，R 2和R 3可以相同或不同，为 氢，烷基，环烷基（例如环丙基，环戊基或环己基），任选取代的苯基或任选取代的苄基，或一起形成亚烷基桥基; 和酸加成盐，金属络合物，羟基的酯和醚衍生物及其立体异构体。 该化合物可用作植物杀真菌剂和植物生长调节剂。

公开(公告)号：US09193791B2

公开(公告)日：2015-11-24

申请号：US13424272

申请日：2012-03-19

申请人： John C. Williams ,  Cindy Zer ,  Kendra N. Avery

发明人： John C. Williams ,  Cindy Zer ,  Kendra N. Avery

IPC分类号： C07K19/00 ,  C07K14/71 ,  C07K16/28 ,  A61K39/00 ,  C07K16/30

CPC分类号： A61K47/481 ,  A61K47/55 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/32 ,  C07K2319/50

摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.

摘要翻译： 在一个实施方案中，提供了掩蔽的单克隆抗体（mAb），由核酸序列或包含信号序列，掩蔽表位序列的氨基酸序列分子编码的mAb，可通过蛋白酶特异性的蛋白酶切割的接头序列 目标组织; 和抗体或其功能片段。 在另一个实施方案中，提供了掩蔽的单克隆抗体（mAb），其包括治疗性mAb和掩模，所述掩模包含蛋白质A和通过蛋白酶切割接头连接的蛋白质L.

公开(公告)号：USD519084S1

公开(公告)日：2006-04-18

申请号：US29183928

申请日：2003-06-20

申请人： Steven J. Hertel ,  John C. Williams ,  Charles J. Ortega

设计人： Steven J. Hertel ,  John C. Williams ,  Charles J. Ortega

公开(公告)号：US5899700A

公开(公告)日：1999-05-04

申请号：US935370

申请日：1997-09-22

申请人： John C. Williams ,  Douglas A. Keyston

发明人： John C. Williams ,  Douglas A. Keyston

IPC分类号： G06F17/30 ,  G09B5/06 ,  G11B7/0033 ,  G11B7/00

CPC分类号： G09B5/062 ,  G06F17/30017 ,  G11B7/0033 ,  Y10S706/927

摘要： Methods and apparatus of integrating multimedia materials with didactic printed materials present selected relevant multimedia material in response to the sensing of control codes embedded in context sensitive and/or content sensitive didactic printed material. A store of multimedia information is created, and the store is correlated to related context and/or content sensitive didactic printed material. The store is categorized to transmit certain categories of the stored information from the store to a multimedia display in response to the reception of certain input signals obtained from certain codes embedded in the didactic printed material. The printed didactic material controls the display of the multimedia material. Either preexisting didactic printed material or currently created didactic printed material can be efficiently and economically integrated with multimedia materials to display certain selected multimedia materials at sensitive places of the printed materials.

摘要翻译： 将多媒体材料与教学印刷材料整合的方法和设备响应于嵌入在上下文敏感和/或内容敏感的教学印刷材料中的控制代码的感测，呈现所选择的相关多媒体材料。 创建多媒体信息存储，并将商店与相关背景和/或内容敏感的教学印刷材料相关联。 响应于从嵌入在教学印刷材料中的特定代码获得的某些输入信号的接收，商店被分类为将存储的信息的某些类别从商店传输到多媒体显示器。 打印的教学材料控制多媒体材料的显示。 预先存在的教学印刷材料或目前创建的教学印刷材料可以高效地和经济地与多媒体材料集成，以在印刷材料的敏感部位显示某些所选择的多媒体材料。