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公开(公告)号：US07951801B2
公开(公告)日：2011-05-31
申请号：US11101998
申请日：2005-04-08
申请人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Prakash Raman , Jeremy D. Little , Paul E. Fleming , Dominic Reynolds , Geraldine C. B. Harriman
发明人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Prakash Raman , Jeremy D. Little , Paul E. Fleming , Dominic Reynolds , Geraldine C. B. Harriman
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D471/04
摘要： This invention provides beta-carboline compounds of formula III-A-aa: wherein Q, G, R1, R2, R3, and R6b are as described in the specification. The compounds are useful for treating diseases such as inflammatory diseases and cancer.
摘要翻译： 本发明提供式III-A-aa的β-咔啉化合物：其中Q，G，R 1，R 2，R 3和R 6b如说明书中所述。 该化合物可用于治疗疾病如炎性疾病和癌症。
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公开(公告)号：US20100093713A1
公开(公告)日：2010-04-15
申请号：US12640335
申请日：2009-12-17
申请人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds
发明人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds
IPC分类号： A61K31/541 , C07D471/04 , A61P35/04 , A61P37/00 , A61K31/5377 , A61P29/00 , A61K31/501 , A61K31/437 , C07D295/10
CPC分类号： C07D265/30 , C07D471/04
摘要： This invention provides beta-carboline compounds of formula wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2 and R3 are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2-mediated diseases such as inflammatory diseases and cancer.
摘要翻译： 本发明提供下式的β-咔啉化合物，其中环A是取代的吡啶基，嘧啶基，吗啉基，哌啶基，哌嗪基，吡咯烷基，吡喃基，四氢呋喃基，环己基，环戊基或硫代吗啉基，R1，R2和R3如说明书中所述。 这些化合物是可用于治疗IKK-2介导的疾病如炎性疾病和癌症的IKK-2抑制剂。
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公开(公告)号：US07727985B2
公开(公告)日：2010-06-01
申请号：US10821545
申请日：2004-04-09
申请人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds
发明人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds
IPC分类号： A61K31/5377 , C07D413/14 , C07D413/02
CPC分类号： C07D265/30 , C07D471/04
摘要： This invention provides beta-carboline compounds of formula I: wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2 and R3 are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2-mediated diseases such as inflammatory diseases and cancer.
摘要翻译： 本发明提供式I的β-咔啉化合物：其中环A是取代的吡啶基，嘧啶基，吗啉基，哌啶基，哌嗪基，吡咯烷基，吡喃基，四氢呋喃基，环己基，环戊基或硫代吗啉基，R1，R2和R3如 规范。 这些化合物是可用于治疗IKK-2介导的疾病如炎性疾病和癌症的IKK-2抑制剂。
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公开(公告)号：US08101604B2
公开(公告)日：2012-01-24
申请号：US12859312
申请日：2010-08-19
IPC分类号： A61K31/437
CPC分类号： C07D471/04
摘要： This invention provides alpha-carboline compounds of formula I: wherein R1, R2, R3, R4, R5, and x are as described in the specification. The compounds are useful for treating inflammatory diseases and cancer.
摘要翻译： 本发明提供了式I的α-咔啉化合物：其中R1，R2，R3，R4，R5和x如说明书中所述。 该化合物可用于治疗炎性疾病和癌症。
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公开(公告)号：US20100311715A1
公开(公告)日：2010-12-09
申请号：US12859312
申请日：2010-08-19
IPC分类号： A61K31/437 , C12N9/99 , A61K31/5377 , A61K31/506 , C07D413/06 , C07D471/04 , C07D401/04 , C07D403/06 , C07D209/34 , A61P35/00 , A61P35/04 , A61P29/00 , A61P37/00 , A61P11/06 , A61P17/06 , A61P1/00
CPC分类号： C07D471/04
摘要： This invention provides alpha-carboline compounds of formula I: wherein R1, R2, R3, R4, R5, and x are as described in the specification. The compounds are useful for treating inflammatory diseases and cancer.
摘要翻译： 本发明提供了式I的α-咔啉化合物：其中R1，R2，R3，R4，R5和x如说明书中所述。 该化合物可用于治疗炎性疾病和癌症。
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公开(公告)号：US07812018B2
公开(公告)日：2010-10-12
申请号：US11706760
申请日：2007-02-15
IPC分类号： A61K31/437 , C07D413/14 , C07D471/06
CPC分类号： C07D471/04
摘要： This invention provides alpha-carboline compounds of formula I: wherein R1, R2, R3, R4, R5, and x are as described in the specification. The compounds are useful for treating inflammatory diseases and cancer.
摘要翻译： 本发明提供了式I的α-咔啉化合物：其中R1，R2，R3，R4，R5和x如说明书中所述。 该化合物可用于治疗炎性疾病和癌症。
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