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    Automated reapplication of atrial pacing therapies
    1.
    发明授权
    Automated reapplication of atrial pacing therapies 有权
    心房起搏治疗的自动再次应用

    公开(公告)号：US06876880B2

    公开(公告)日：2005-04-05

    申请号：US10034060

    申请日：2001-12-20

    申请人： Michael F. Hess ,  Rahul Mehra ,  Eduardo N. Warman ,  Nirav V. Sheth ,  Mark L. Brown ,  David Ritscher

    发明人： Michael F. Hess ,  Rahul Mehra ,  Eduardo N. Warman ,  Nirav V. Sheth ,  Mark L. Brown ,  David Ritscher

    IPC分类号： A61N1/365 ,  A61N1/362 ,  A61N1/39

    CPC分类号： A61N1/3622 ,  A61N1/3624

    摘要： The invention relates to the use of atrial pacing therapies to treat atrial tachycardia (AT). When an AT episode is detected, an implantable medical device applies an ATP therapy. If the AT episode persists, the ATP therapy may be automatically reapplied at a later time during the course of the same AT episode. In particular, previously used ATP therapies are reapplied when episodic conditions, such as cycle length or cycle regularity, change. Although a particular ATP therapy initially may be unsuccessful in terminating the AT, it may prove successful when the cycle length or regularity of the atrial rhythm changes. As the rhythm slows down, the AT may be more responsive to ATP therapies that were previously unsuccessful. As a result, potentially efficacious ATP therapies can be reapplied to terminate AT episodes, and reduce the number of episodes that require more aggressive termination by painful, atrial shocks.

    摘要翻译： 本发明涉及心房起搏疗法用于治疗房性心动过速（AT）的用途。 当检测到AT发作时，可植入医疗装置应用ATP疗法。 如果AT发作持续存在，ATP疗法可能会在相同的AT发作过程中的较晚时间自动重新应用。 特别是，当诸如循环长度或循环规律性等情况时，先前使用的ATP疗法将被重新应用。 尽管特定的ATP疗法最初可能不能终止AT，但是当心房节律的周期长度或规律性发生变化时，可能会成功。 随着节奏减慢，AT可能对以前不成功的ATP疗法更有反应。 因此，可以重新应用潜在有效的ATP疗法来终止AT发作，并通过痛苦的心房休克减少需要更积极终止的发作次数。

    Arrangement and system for enabling patient control of electrical therapies
    3.
    发明授权
    Arrangement and system for enabling patient control of electrical therapies 有权
    用于使患者能够控制电疗的安排和系统

    公开(公告)号：US06804554B2

    公开(公告)日：2004-10-12

    申请号：US10053035

    申请日：2001-10-19

    申请人： Michael R. Ujhelyi ,  Rahul Mehra ,  Nirav V. Sheth ,  Nancy Perry Pool

    发明人： Michael R. Ujhelyi ,  Rahul Mehra ,  Nirav V. Sheth ,  Nancy Perry Pool

    IPC分类号： A61N130

    CPC分类号： A61N1/3956 ,  A61N1/37247 ,  A61N1/37258 ,  A61N1/3987

    摘要： A patient-controlled system for temporarily disabling an electrical cardioverting therapy in order to prepare the patient psychologically and physiologically for the pain associated with electrical cardioversion therapy. In an example embodiment, the system includes a capacitive circuit capable of charging and discharging in order to apply the electrical therapy. The implanted medical device automatically causes the capacitive circuit to charge and discharge at least once within a selected period. The system includes a patient activator device that communicates with the implanted device. A disabling circuit is also included within the implanted medical device that temporarily disables the electrical therapy application in response to the patient activator device. The system further includes an alerting arrangement that alerts the patient activator device in response to the disabling circuit. An override circuit overrides the temporary disabling of the electrical therapy application in response to the patient being in a relaxed mode.

    摘要翻译： 一种患者控制的系统，用于临时禁用电复律治疗，以便心理和生理地为患者提供与电复律治疗相关的疼痛。 在示例性实施例中，系统包括能够进行充电和放电以便施加电疗法的电容电路。 植入的医疗装置自动使电容电路在选定的时间内至少进行一次充电和放电。 该系统包括与植入装置通信的患者激活装置。 在植入式医疗装置中还包括禁用电路，其暂时禁用响应于患者激活装置的电疗应用。 该系统还包括警报装置，其响应于禁用电路来警告患者激活装置。 覆盖电路覆盖响应于患者处于放松模式的电疗治疗应用的暂时禁用。

    Apparatus for treating atrial tachyarrhythmias with synchronized shocks
    4.
    发明授权
    Apparatus for treating atrial tachyarrhythmias with synchronized shocks 失效
    用同步冲击治疗房性快速性心律失常的装置

    公开(公告)号：US6091988A

    公开(公告)日：2000-07-18

    申请号：US70690

    申请日：1998-04-30

    申请人： Eduardo N. Warman ,  Michael R. S. Hill ,  David K. L. Peterson ,  Rahul Mehra ,  Luc R. Mongeon

    发明人： Eduardo N. Warman ,  Michael R. S. Hill ,  David K. L. Peterson ,  Rahul Mehra ,  Luc R. Mongeon

    IPC分类号： A61N1/362 ,  A61N1/39

    CPC分类号： A61N1/3956 ,  A61N1/3622 ,  A61N1/3987

    摘要： An implantable anti-tachyarrhythmia device which delivers atrial cardioversion or defibrillation pulses heart in response to detection of atrial tachyarrhythmias. The pulses are synchronized to atrial and ventricular events in such a fashion as to assure they occur outside of the vulnerable periods associated with both chambers. The device is provided with a pulse synchronizer which defines a first synchronization interval initiated following a sensed atrial event and a second synchronization interval initiated responsive to a sensed ventricular event and a pulse triggerer which triggers delivery of a cardioversion or defibrillation pulse responsive to the first and second synchronization intervals simultaneously being underway. In particular, the pulse triggerer may be responsive to initiation of the first synchronization interval during the second synchronization interval. In addition, the synchronizer may also define minimum time intervals following ventricular events and the triggerer may additionally be responsive to expiration of a defined minimum time interval following a ventricular event preceding the sensed ventricular event which initiated the second synchronization interval currently underway.

    摘要翻译： 一种可植入的抗快速性心律失常装置，其响应于心房快速性心律失常的检测而传送心房心脏复律或除颤脉冲心脏。 这些脉冲以这样的方式与心房和心室事件同步，以确保它们发生在与两个腔室相关联的脆弱周期之外。 该装置设置有脉冲同步器，该脉冲同步器限定在感测的心房事件之后启动的第一同步间隔和响应于感测到的心室事件而发起的第二同步间隔和脉冲触发器，其响应于第一和第二同步间隔触发心脏复律或除颤脉冲的传递 第二同步间隔同时进行。 特别地，脉冲触发器可以响应于在第二同步间隔期间启动第一同步间隔。 此外，同步器还可以定义心室事件之后的最小时间间隔，并且触发器可以另外响应于起始于当前正在进行的第二同步区间的感测的心室事件之前的心室事件之后的限定的最小时间间隔的到期。

    Method and apparatus for diagnosis and treatment of arrhythmias
    5.
    发明授权
    Method and apparatus for diagnosis and treatment of arrhythmias 失效
    用于诊断和治疗心律失常的方法和装置

    公开(公告)号：US5968079A

    公开(公告)日：1999-10-19

    申请号：US40544

    申请日：1998-03-18

    申请人： Eduardo N. Warman ,  Rahul Mehra

    发明人： Eduardo N. Warman ,  Rahul Mehra

    IPC分类号： A61N1/39 ,  A61N1/368

    CPC分类号： A61N1/3962 ,  A61N1/395

    摘要： An implantable medical device which senses atrial electrograms, detects atrial tachyarrhythmias and delivers atrial cardioversion/defibrillation pulses in response thereto, which employ a correlation analysis to assist in detection of arrhythmias and/or timing of delivery of cardioversion/defibrillation shocks. The device includes an electrogram recorder which stores atrial electrogram segments associated with R--R intervals extending over multiple atrial depolarizations and a correlator which measures correlation of successive stored atrial electrogram segments. The device may use the measured corellation meeting a defined threshold value to detect the occurrence of a defined tachyarrhythmia such as atrial fibrillation or allow delivery of a cardioversion/defibrillation pulse.

    摘要翻译： 感测心房电图的可植入医疗装置，检测心房快速性心律失常并响应于此传递心房复律/除颤脉冲，其使用相关分析来辅助检测心律不齐和/或转发/除颤电击的递送时机。 该装置包括电描记录记录器，其存储与跨多个心房去极化延伸的R-R间隔相关联的心房电描绘片段，以及测量连续存储的心房电描记图片段的相关性的相关器。 该装置可以使用满足定义的阈值的测量的核心数来检测定义的心律失常的发生，例如心房颤动或允许递送心脏复律/除颤脉冲。

    Device and method for determining tissue thickness and creating cardiac ablation lesions
    9.
    发明授权
    Device and method for determining tissue thickness and creating cardiac ablation lesions 失效
    用于确定组织厚度并产生心脏消融病变的装置和方法

    公开(公告)号：US08333764B2

    公开(公告)日：2012-12-18

    申请号：US10844213

    申请日：2004-05-12

    申请人： David E. Francischelli ,  Eduardo N. Warman ,  Rahul Mehra

    发明人： David E. Francischelli ,  Eduardo N. Warman ,  Rahul Mehra

    IPC分类号： A61B18/14

    CPC分类号： A61B18/1442 ,  A61B2018/00666 ,  A61B2018/1861 ,  A61B2090/061 ,  A61B2090/064

    摘要： A tissue ablation device has a handle and an ablation head coupled to the handle. The ablation head has a first jaw, a second jaw, and an ablative element coupled to at least one of the first and second jaws. A thickness measurement device may be coupled to the ablation device to indicate the distance separating the first and second jaws. Further, a force measurement device may be coupled to the ablation device to measure the force being applied by the first and second jaws to a piece of tissue. Further, a strain measurement device may be coupled to the ablation device to indicate the strain resulting in a piece of tissue disposed between the first and second jaws when a stress is applied to the tissue.

    摘要翻译： 组织消融装置具有手柄和联接到手柄的消融头。 消融头具有联接到第一和第二钳口中的至少一个的第一钳口，第二钳口和消融元件。 厚度测量装置可以联接到消融装置以指示分离第一和第二钳口的距离。 此外，力测量装置可以联接到消融装置以测量由第一和第二钳口施加到一片组织上的力。 此外，当应力施加到组织时，应变测量装置可以联接到消融装置以指示当应力施加到组织上时产生设置在第一和第二钳口之间的一片组织的应变。