公开(公告)号：US07366570B2

公开(公告)日：2008-04-29

申请号：US10376061

申请日：2003-02-26

申请人： Kenneth M. Riff ,  Patrick M. Mahoney ,  Clifton W. Owens ,  Rahul Mehra ,  Michael F. Hess ,  Nirav V. Sheth ,  Nancy Perry Pool ,  Michael R. Ujhelyi

发明人： Kenneth M. Riff ,  Patrick M. Mahoney ,  Clifton W. Owens ,  Rahul Mehra ,  Michael F. Hess ,  Nirav V. Sheth ,  Nancy Perry Pool ,  Michael R. Ujhelyi

IPC分类号： A61N1/08

CPC分类号： A61N1/37258 ,  A61B5/0031 ,  A61N1/37252 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G16H10/60 ,  G16H15/00 ,  G16H40/63

摘要： A method and system facilitates the access by a patient of implanted medical device related data for patient participation in their own clinical care and therapy. In an example embodiment, the method includes establishing a communications link between an implanted medical device and a data processor via an implanted medical device interface. Access to a secured database is obtained via the implanted device data processor using a set of patient identification data. A query is then submitted via the data processor to the secured database in response to input patient diagnostic data. Data received from the secured database is then displayed for use in a patient evaluation.

摘要翻译： 一种方法和系统便于患者接触植入的医疗装置相关数据，以使患者参与其自身临床护理和治疗。 在示例实施例中，该方法包括经由植入的医疗设备接口在植入的医疗设备和数据处理器之间建立通信链路。 通过使用一组患者识别数据的植入装置数据处理器获得对安全数据库的访问。 然后，响应于输入的患者诊断数据，通过数据处理器将查询提交到安全数据库。 然后显示从安全数据库接收到的数据以用于患者评估。

公开(公告)号：US06804554B2

公开(公告)日：2004-10-12

申请号：US10053035

申请日：2001-10-19

申请人： Michael R. Ujhelyi ,  Rahul Mehra ,  Nirav V. Sheth ,  Nancy Perry Pool

发明人： Michael R. Ujhelyi ,  Rahul Mehra ,  Nirav V. Sheth ,  Nancy Perry Pool

IPC分类号： A61N130

CPC分类号： A61N1/3956 ,  A61N1/37247 ,  A61N1/37258 ,  A61N1/3987

摘要： A patient-controlled system for temporarily disabling an electrical cardioverting therapy in order to prepare the patient psychologically and physiologically for the pain associated with electrical cardioversion therapy. In an example embodiment, the system includes a capacitive circuit capable of charging and discharging in order to apply the electrical therapy. The implanted medical device automatically causes the capacitive circuit to charge and discharge at least once within a selected period. The system includes a patient activator device that communicates with the implanted device. A disabling circuit is also included within the implanted medical device that temporarily disables the electrical therapy application in response to the patient activator device. The system further includes an alerting arrangement that alerts the patient activator device in response to the disabling circuit. An override circuit overrides the temporary disabling of the electrical therapy application in response to the patient being in a relaxed mode.

摘要翻译： 一种患者控制的系统，用于临时禁用电复律治疗，以便心理和生理地为患者提供与电复律治疗相关的疼痛。 在示例性实施例中，系统包括能够进行充电和放电以便施加电疗法的电容电路。 植入的医疗装置自动使电容电路在选定的时间内至少进行一次充电和放电。 该系统包括与植入装置通信的患者激活装置。 在植入式医疗装置中还包括禁用电路，其暂时禁用响应于患者激活装置的电疗应用。 该系统还包括警报装置，其响应于禁用电路来警告患者激活装置。 覆盖电路覆盖响应于患者处于放松模式的电疗治疗应用的暂时禁用。

公开(公告)号：US06876880B2

公开(公告)日：2005-04-05

申请号：US10034060

申请日：2001-12-20

申请人： Michael F. Hess ,  Rahul Mehra ,  Eduardo N. Warman ,  Nirav V. Sheth ,  Mark L. Brown ,  David Ritscher

发明人： Michael F. Hess ,  Rahul Mehra ,  Eduardo N. Warman ,  Nirav V. Sheth ,  Mark L. Brown ,  David Ritscher

IPC分类号： A61N1/365 ,  A61N1/362 ,  A61N1/39

CPC分类号： A61N1/3622 ,  A61N1/3624

摘要： The invention relates to the use of atrial pacing therapies to treat atrial tachycardia (AT). When an AT episode is detected, an implantable medical device applies an ATP therapy. If the AT episode persists, the ATP therapy may be automatically reapplied at a later time during the course of the same AT episode. In particular, previously used ATP therapies are reapplied when episodic conditions, such as cycle length or cycle regularity, change. Although a particular ATP therapy initially may be unsuccessful in terminating the AT, it may prove successful when the cycle length or regularity of the atrial rhythm changes. As the rhythm slows down, the AT may be more responsive to ATP therapies that were previously unsuccessful. As a result, potentially efficacious ATP therapies can be reapplied to terminate AT episodes, and reduce the number of episodes that require more aggressive termination by painful, atrial shocks.

摘要翻译： 本发明涉及心房起搏疗法用于治疗房性心动过速（AT）的用途。 当检测到AT发作时，可植入医疗装置应用ATP疗法。 如果AT发作持续存在，ATP疗法可能会在相同的AT发作过程中的较晚时间自动重新应用。 特别是，当诸如循环长度或循环规律性等情况时，先前使用的ATP疗法将被重新应用。 尽管特定的ATP疗法最初可能不能终止AT，但是当心房节律的周期长度或规律性发生变化时，可能会成功。 随着节奏减慢，AT可能对以前不成功的ATP疗法更有反应。 因此，可以重新应用潜在有效的ATP疗法来终止AT发作，并通过痛苦的心房休克减少需要更积极终止的发作次数。

公开(公告)号：US07951137B2

公开(公告)日：2011-05-31

申请号：US11244764

申请日：2005-10-06

申请人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

发明人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

IPC分类号： A61K9/22 ,  A61N1/00 ,  A61B5/04

CPC分类号： A61M5/14244 ,  A61B2017/00044 ,  A61M5/1723 ,  A61M2230/04 ,  A61N1/3621

摘要： A method and system is provided for responding, from internally within a patient, to an atrial arrhythmia in a heart including measuring from within the patient at least one electrocardiogram characteristic indicative of the atrial arrhythmia, and controlling from within the patient drug therapy delivery to the patient responsive to measuring the at least one electrocardiogram characteristic. Drug therapy is initiated to the patient responsive to measuring the at least one electrocardiogram characteristic. According to one aspect of the present invention, the drug therapy is staged within the patient prior to measuring the at least one electrocardiogram characteristic. According to another example embodiment, the heart is paced from within the patient at a predefined rate responsive to measuring the at least one electrocardiogram characteristic, pacing occurring alone, or in combination with drug therapy.

摘要翻译： 提供了一种方法和系统，用于从患者内部响应于心脏中的心房心律失常，包括从患者内测量至少一个指示心房心律失常的心电图特征，以及从患者内控制药物治疗递送至 响应于测量至少一个心电图特征的患者。 响应于测量至少一个心电图特征，向患者开始药物治疗。 根据本发明的一个方面，在测量至少一个心电图特征之前，药物治疗在患者体内分期。 根据另一示例性实施例，响应于测量至少一个心电图特征，单独起搏或与药物治疗组合，心脏以预定速率从患者体内起搏。

公开(公告)号：US07336994B2

公开(公告)日：2008-02-26

申请号：US10760155

申请日：2004-01-16

申请人： Douglas A. Hettrick ,  David E. Euler ,  Eduardo N. Warman ,  Michael R. Ujhelyi ,  Rahul Mehra ,  Paul D. Ziegler ,  Shailesh Kumar V. Musley ,  Charles E. Distad ,  David E. Ritscher

发明人： Douglas A. Hettrick ,  David E. Euler ,  Eduardo N. Warman ,  Michael R. Ujhelyi ,  Rahul Mehra ,  Paul D. Ziegler ,  Shailesh Kumar V. Musley ,  Charles E. Distad ,  David E. Ritscher

IPC分类号： A61N1/39

CPC分类号： A61N1/3702 ,  A61N1/3621 ,  A61N1/365 ,  A61N1/36564 ,  A61N1/395 ,  A61N1/3962

摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDs) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.

摘要翻译： 公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMD）递送的除颤疗法。 血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。 具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。 因此，对于血液动力学良性心律失常，禁止使用除颤疗法。

公开(公告)号：US07186247B2

公开(公告)日：2007-03-06

申请号：US10407996

申请日：2003-04-04

申请人： Michael R. Ujhelyi ,  Rahul Mehra ,  Xiaoyi Min

发明人： Michael R. Ujhelyi ,  Rahul Mehra ,  Xiaoyi Min

IPC分类号： A61K9/22 ,  A61M31/00

CPC分类号： A61M5/14276 ,  A61M5/14244 ,  A61M5/16813 ,  A61M2205/0266 ,  A61N1/0568

摘要： A medical delivery system for delivering a fluid to a desired location within a body that includes a first member having an aperture, and a second member adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device, formed by at least one of the first member and the second member. The medical delivery system includes means for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture.

摘要翻译： 一种用于将流体输送到包括具有孔的第一构件的主体内的期望位置的医疗输送系统，以及适于定位在第一构件上方的第二构件。 待输送的流体被包含在由第一构件和第二构件中的至少一个形成的流体存储装置内。 医疗输送系统包括用于在通过孔的流体的第一状态阻止通道和允许流体从流体存储装置向外通过孔的第二状态之间相对于第二构件重新定位第一构件的装置。

公开(公告)号：US06968226B2

公开(公告)日：2005-11-22

申请号：US10059824

申请日：2002-01-30

申请人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

发明人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

IPC分类号： A61B5/0402 ,  A61B5/0472 ,  A61B17/00 ,  A61K31/18 ,  A61M5/142 ,  A61M5/172 ,  A61M37/00 ,  A61N1/362 ,  A61N1/365 ,  A61P9/06 ,  A61B5/04

CPC分类号： A61M5/14244 ,  A61B2017/00044 ,  A61M5/1723 ,  A61M2230/04 ,  A61N1/3621

摘要： A method and system is provided for responding, from internally within a patient, to an atrial arrhythmia in a heart including measuring from within the patient at least one electrocardiogram characteristic indicative of the atrial arrhythmia, and controlling from within the patient drug therapy delivery to the patient responsive to measuring the at least one electrocardiogram characteristic. Drug therapy is initiated to the patient responsive to measuring the at least one electrocardiogram characteristic. According to one aspect of the present invention, the drug therapy is staged within the patient prior to measuring the at least one electrocardiogram characteristic. According to another example embodiment, the heart is paced from within the patient at a predefined rate responsive to measuring the at least one electrocardiogram characteristic, pacing occurring alone, or in combination with drug therapy.

摘要翻译： 提供了一种方法和系统，用于从患者内部响应于心脏中的心房心律失常，包括从患者内测量至少一个指示心房心律失常的心电图特征，以及从患者内控制药物治疗递送至 响应于测量至少一个心电图特征的患者。 响应于测量至少一个心电图特征，向患者开始药物治疗。 根据本发明的一个方面，在测量至少一个心电图特征之前，药物治疗在患者体内分期。 根据另一示例性实施例，响应于测量至少一个心电图特征，单独起搏或与药物治疗组合，心脏以预定速率从患者体内起搏。

公开(公告)号：US06728574B2

公开(公告)日：2004-04-27

申请号：US10040147

申请日：2001-10-19

申请人： Michael R. Ujhelyi ,  Rahul Mehra

发明人： Michael R. Ujhelyi ,  Rahul Mehra

IPC分类号： A61N100

CPC分类号： A61N1/3956 ,  A61N1/3987

摘要： A pain management system that enables a patient to control pain associated with the application of electrical therapies by an implanted device that includes using a non-implanted drug delivery device. In an example embodiment, a pain management system includes an implanted medical device that detects an arrhythmia of a heart and telemetrically communicates from the implanted medical device an arrhythmia condition. The system also includes an external drug delivery arrangement that receives telemetric communications on the arrhythmia condition from the implanted device and provides an alert of the arrhythmia condition to the patient. The external drug delivery arrangement communicates to the implanted device that a drug is being administered to the patient. The implanted medical device includes a capacitive circuit that delivers the electrical therapy to the heart in response to the drug being administered.

摘要翻译： 一种疼痛管理系统，其使患者能够通过包括使用非植入药物递送装置的植入装置来控制与电疗法的应用相关的疼痛。 在示例性实施例中，疼痛管理系统包括植入式医疗装置，其检测心脏的心律失常并且从植入的医疗装置与心律失常状况进行遥测通信。 该系统还包括外部药物递送装置，其从植入装置接收心律不齐状况的遥测通信，并且向患者提供心律失常状态的警报。 外部药物递送装置与植入装置通信药物被施用于患者。 植入的医疗装置包括电容电路，其响应于施用的药物将电疗法递送到心脏。

公开(公告)号：US07722598B2

公开(公告)日：2010-05-25

申请号：US11675693

申请日：2007-02-16

申请人： Michael R. Ujhelyi ,  Rahul Mehra ,  Xiaoyi Min

发明人： Michael R. Ujhelyi ,  Rahul Mehra ,  Xiaoyi Min

IPC分类号： A61K9/22

CPC分类号： A61M5/14276 ,  A61M5/14244 ,  A61M5/16813 ,  A61M2205/0266 ,  A61N1/0568

摘要： A medical delivery system for delivering a fluid to a desired location within a body that includes a first member having an aperture, and a second member adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device, formed by at least one of the first member and the second member. The medical delivery system includes means for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture.

摘要翻译： 一种用于将流体输送到包括具有孔的第一构件的主体内的期望位置的医疗输送系统，以及适于定位在第一构件上方的第二构件。 待输送的流体被包含在由第一构件和第二构件中的至少一个形成的流体存储装置内。 医疗输送系统包括用于在通过孔的流体的第一状态阻止通道和允许流体从流体存储装置向外通过孔的第二状态之间相对于第二构件重新定位第一构件的装置。

公开(公告)号：US08512337B2

公开(公告)日：2013-08-20

申请号：US10923073

申请日：2004-08-20

申请人： David E. Francischelli ,  Rahul Mehra

发明人： David E. Francischelli ,  Rahul Mehra

IPC分类号： A61B18/12

CPC分类号： A61B18/1445 ,  A61B18/1402 ,  A61B2017/2945 ,  A61B2018/00994 ,  A61B2018/126 ,  A61B2018/1432 ,  A61B2018/1472

摘要： A method of and a system for treatment of atrial tachyarrhythmias. The system includes a set of hemostats having elongated opposing jaws carrying mechanisms for applying ablation energy along the jaws. The jaws having straight and curved configurations selected to allow arrangement of the jaws of along opposite sides of walls of a patient's atrium. Treatment is accomplished by applying of ablation energy to the walls of a patient's artria to create lines of lesion corresponding generally to incisions employed in a Maze type procedure.

摘要翻译： 一种治疗房性快速性心律失常的方法和系统。 该系统包括一组具有延长的相对的夹爪的止血器，该钳口携带用于沿钳口施加消融能量的机构。 钳口具有直的和弯曲的构造，其被选择为允许沿着病人心房的壁的相对侧布置钳口。 通过将消融能量施加到患者的肌肉的壁上来实现治疗，以产生通常对于迷宫类型手术中使用的切口相应的损伤线。