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14 条记录 (耗时 0.025 秒)

    Inhibition of complement activation
    5.
    发明授权
    Inhibition of complement activation 有权
    补体激活的抑制

    公开(公告)号：US07439331B2

    公开(公告)日：2008-10-21

    申请号：US11478089

    申请日：2006-06-29

    申请人： Michael S. C. Fung ,  William N. C. Sun ,  Cecily R. Y. Sun

    发明人： Michael S. C. Fung ,  William N. C. Sun ,  Cecily R. Y. Sun

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/44

    CPC分类号： C07K16/40 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2319/00

    摘要： The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.

    摘要翻译： 本发明涉及与因子D结合并阻断因子D在补体激活中的功能活性的因子D抑制剂。 抑制剂包括抗体分子，以及同系物，类似物及其修饰或衍生形式，包括免疫球蛋白片段如Fab，F（ab'）2和Fv，小分子，包括肽，寡核苷酸，肽模拟物 和有机化合物。 产生与因子D结合并阻断其激活补体的能力的单克隆抗体，并命名为166-32。 产生该抗体的杂交瘤保藏在American Type Culture Collection，10801 University Blvd.，Manassas，Va。20110-2209，登录号HB-12476。

    Nucleic acids encoding antibodies that bind factor D
    6.
    发明授权
    Nucleic acids encoding antibodies that bind factor D 有权
    编码结合因子D的抗体的核酸

    公开(公告)号：US08383802B2

    公开(公告)日：2013-02-26

    申请号：US13540275

    申请日：2012-07-02

    申请人： Michael S. C. Fung ,  William N. C. Sun ,  Cecily R. Y. Sun

    发明人： Michael S. C. Fung ,  William N. C. Sun ,  Cecily R. Y. Sun

    IPC分类号： C12N15/13 ,  C12N15/00 ,  C12N5/10

    CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76

    摘要： The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.

    摘要翻译： 本发明涉及与因子D结合并阻断因子D在补体激活中的功能活性的因子D抑制剂。 抑制剂包括抗体分子，以及同系物，类似物及其修饰或衍生形式，包括免疫球蛋白片段如Fab，F（ab'）2和Fv，小分子，包括肽，寡核苷酸，肽模拟物和有机化合物。 产生与因子D结合并阻断其激活补体的能力的单克隆抗体，并命名为166-32。 产生该抗体的杂交瘤保藏在American Type Culture Collection，10801 University Blvd.，Manassas，Va。20110-2209，登录号HB-12476。

    Complement inhibitors and uses thereof
    7.
    发明授权
    Complement inhibitors and uses thereof 有权
    补体抑制剂及其用途

    公开(公告)号：US08911735B2

    公开(公告)日：2014-12-16

    申请号：US13524465

    申请日：2012-06-15

    申请人： Michael S. C. Fung ,  Cecily R. Y. Sun ,  William N. C. Sun

    发明人： Michael S. C. Fung ,  Cecily R. Y. Sun ,  William N. C. Sun

    IPC分类号： A61K39/395 ,  C07K16/40 ,  A61K39/00

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/55

    摘要： The invention relates to C2a inhibitors, which bind to C2a and block the functional activity of C2a in complement activation. The inhibitors include antibody molecules, as well as homologs, analogs and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody, which bound to C2a and blocked its ability to activate complement was generated and designated 175-62. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number PTA-1553.

    摘要翻译： 本发明涉及C2a抑制剂，其与C2a结合并阻断C2a在补体活化中的功能活性。 抑制剂包括抗体分子，以及同系物，类似物及其修饰或衍生形式，包括免疫球蛋白片段如Fab，F（ab'）2和Fv，小分子，包括肽，寡核苷酸，肽模拟物和有机化合物。 产生与C2a结合并阻断其激活补体的能力的单克隆抗体，并命名为175-62。 产生该抗体的杂交瘤保藏在American Type Culture Collection，10801 University Blvd.，Manassas，Va。20110-2209，保藏号PTA-1553。

    Inhibitors of complement activation
    8.
    发明授权
    Inhibitors of complement activation 有权
    补体激活抑制剂

    公开(公告)号：US06956107B2

    公开(公告)日：2005-10-18

    申请号：US09821255

    申请日：2001-03-29

    申请人： Michael S. C. Fung ,  William N. C. Sun ,  Cecily R. Y. Sun

    发明人： Michael S. C. Fung ,  William N. C. Sun ,  Cecily R. Y. Sun

    IPC分类号： A61K38/00 ,  C07K16/40 ,  C11N5/12 ,  C07K16/36

    CPC分类号： C07K16/40 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2319/00

    摘要： The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.

    摘要翻译： 本发明涉及与因子D结合并阻断因子D在补体激活中的功能活性的因子D抑制剂。 抑制剂包括抗体分子，以及同系物，类似物及其修饰或衍生形式，包括免疫球蛋白片段如Fab，F（ab'）2和Fv，小分子，包括肽，寡核苷酸，肽模拟物 和有机化合物。 产生与因子D结合并阻断其激活补体的能力的单克隆抗体，并命名为166-32。 产生该抗体的杂交瘤保藏在American Type Culture Collection，10801 University Blvd.，Manassas，Va。20110-2209，登录号HB-12476。

    Anti-factor D antibodies and methods of treatment
    9.
    发明授权
    Anti-factor D antibodies and methods of treatment 有权
    抗因子D抗体和治疗方法

    公开(公告)号：US08124090B2

    公开(公告)日：2012-02-28

    申请号：US13081203

    申请日：2011-04-06

    申请人： Michael S. C. Fung ,  William N. C. Sun ,  Cecily R. Y. Sun

    发明人： Michael S. C. Fung ,  William N. C. Sun ,  Cecily R. Y. Sun

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/36 ,  G01N33/53

    CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76

    摘要： The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.

    摘要翻译： 本发明涉及与因子D结合并阻断因子D在补体激活中的功能活性的因子D抑制剂。 抑制剂包括抗体分子，以及同系物，类似物及其修饰或衍生形式，包括免疫球蛋白片段如Fab，F（ab'）2和Fv，小分子，包括肽，寡核苷酸，肽模拟物和有机化合物。 产生与因子D结合并阻断其激活补体的能力的单克隆抗体，并命名为166-32。 产生该抗体的杂交瘤保藏在American Type Culture Collection，10801 University Blvd.，Manassas，Va。20110-2209，登录号HB-12476。

    Method of treatment using anti-factor D antibodies
    10.
    发明授权
    Method of treatment using anti-factor D antibodies 有权
    使用抗因子D抗体的治疗方法

    公开(公告)号：US07943135B2

    公开(公告)日：2011-05-17

    申请号：US11478088

    申请日：2006-06-29

    申请人： Michael S. C. Fung ,  William N. C. Sun ,  Cecily R. Y. Sun

    发明人： Michael S. C. Fung ,  William N. C. Sun ,  Cecily R. Y. Sun

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/36

    CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76

    摘要： The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.

    摘要翻译： 本发明涉及与因子D结合并阻断因子D在补体激活中的功能活性的因子D抑制剂。 抑制剂包括抗体分子，以及同系物，类似物及其修饰或衍生形式，包括免疫球蛋白片段如Fab，F（ab'）2和Fv，小分子，包括肽，寡核苷酸，肽模拟物和有机化合物。 产生与因子D结合并阻断其激活补体的能力的单克隆抗体，并命名为166-32。 产生该抗体的杂交瘤保藏在American Type Culture Collection，10801 University Blvd.，Manassas，Va。20110-2209，登录号HB-12476。