公开(公告)号：US07138480B2

公开(公告)日：2006-11-21

申请号：US10378201

申请日：2003-03-03

申请人： Michael G. Bramucci ,  Robert Dicosimo ,  Robert Fallon ,  John E. Gavagan ,  Frank Herkes ,  Lech Wilczek

发明人： Michael G. Bramucci ,  Robert Dicosimo ,  Robert Fallon ,  John E. Gavagan ,  Frank Herkes ,  Lech Wilczek

IPC分类号： C08G63/06

CPC分类号： C12P7/625 ,  C08G63/06 ,  C08G63/85 ,  C12P7/42 ,  C12R1/01 ,  C12R1/40

摘要： This invention relates to a process for the preparation of a 3-hydroxycarboxylic acid from a 3-hydroxynitrile. More specifically, 3-hydroxyvaleronitrile is converted to 3-hydroxyvaleric acid in high yield at up to 100% conversion, using as an enzyme catalyst 1) nitrile hydratase activity and amidase activity or 2) nitrilase activity of a microbial cell. 3-Hydroxyvaleric acid is used as a substitute for ε-caprolactone in the preparation of highly branched copolyester.

摘要翻译： 本发明涉及一种由3-羟基腈制备3-羟基羧酸的方法。 更具体地，使用酶催化剂1）腈水合酶活性和酰胺酶活性或2）微生物细胞的腈水解酶活性，将3-羟基戊腈以高产率转化为3-羟基戊酸。 3-羟基戊酸用于制备高支化共聚酯中的ε-己内酯的替代物。

公开(公告)号：US07091011B2

公开(公告)日：2006-08-15

申请号：US10378202

申请日：2003-03-03

申请人： Michael G. Bramucci ,  Robert Dicosimo ,  Robert Fallon ,  John E. Gavagan ,  Frank Herkes ,  Lech Wilczek

发明人： Michael G. Bramucci ,  Robert Dicosimo ,  Robert Fallon ,  John E. Gavagan ,  Frank Herkes ,  Lech Wilczek

IPC分类号： C12P7/62 ,  C12P13/00

CPC分类号： C12P7/625 ,  C08G63/06 ,  C08G63/85 ,  C12P7/42 ,  C12R1/01 ,  C12R1/40

摘要： This invention relates to a process for the preparation of a 3-hydroxycarboxylic acid from a 3-hydroxynitrile. More specifically, 3-hydroxyvaleronitrile is converted to 3-hydroxyvaleric acid in high yield at up to 100% conversion, using as an enzyme catalyst 1) nitrile hydratase activity and amidase activity or 2) nitrilase activity of a microbial cell. 3-Hydroxyvaleric acid is used as a substitute for ε-caprolactone in the preparation of highly branched copolyester.

公开(公告)号：US06562603B2

公开(公告)日：2003-05-13

申请号：US09921260

申请日：2001-08-02

申请人： Michael G. Bramucci ,  Robert Dicosimo ,  Robert Fallon ,  John E. Gavagan ,  Frank Herkes ,  Lech Wilczek

发明人： Michael G. Bramucci ,  Robert Dicosimo ,  Robert Fallon ,  John E. Gavagan ,  Frank Herkes ,  Lech Wilczek

IPC分类号： C12P742

CPC分类号： C12P7/625 ,  C08G63/06 ,  C08G63/85 ,  C12P7/42 ,  C12R1/01 ,  C12R1/40

摘要： This invention relates to a process for the preparation of a 3-hydroxycarboxylic acid from a 3-hydroxynitrile. More specifically, 3-hydroxyvaleronitrile is converted to 3-hydroxyvaleric acid in high yield at up to 100% conversion, using as an enzyme catalyst 1) nitrile hydratase activity and amidase activity or 2) nitrilase activity of a microbial cell. 3-Hydroxyvaleric acid is used as a substitute for &egr;-caprolactone in the preparation of highly branched copolyester.

摘要翻译： 本发明涉及一种由3-羟基腈制备3-羟基羧酸的方法。 更具体地，使用酶催化剂1）腈水合酶活性和酰胺酶活性或2）微生物细胞的腈水解酶活性，将3-羟基戊腈以高产率转化为3-羟基戊酸。 在制备高支化共聚酯时，使用3-羟基戊酸作为ε-己内酯的替代物。

公开(公告)号：US20070004017A1

公开(公告)日：2007-01-04

申请号：US11516408

申请日：2006-09-05

申请人： Michael Bramucci ,  Robert Dicosimo ,  Robert Fallon ,  John Gavagan ,  Frank Herkes ,  Lech Wilczek

发明人： Michael Bramucci ,  Robert Dicosimo ,  Robert Fallon ,  John Gavagan ,  Frank Herkes ,  Lech Wilczek

IPC分类号： C12P7/40 ,  C12N9/80 ,  C12N1/21

CPC分类号： C12P7/625 ,  C08G63/06 ,  C08G63/85 ,  C12P7/42 ,  C12R1/01 ,  C12R1/40

摘要： This invention relates to a process for the preparation of a 3-hydroxycarboxylic acid from a 3-hydroxynitrile. More specifically, 3-hydroxyvaleronitrile is converted to 3-hydroxyvaleric acid in high yield at up to 100% conversion, using as an enzyme catalyst 1) nitrile hydratase activity and amidase activity or 2) nitrilase activity of a microbial cell. 3-Hydroxyvaleric acid is used as a substitute for ε-caprolactone in the preparation of highly branched copolyester.

摘要翻译： 本发明涉及一种由3-羟基腈制备3-羟基羧酸的方法。 更具体地，使用酶催化剂1）腈水合酶活性和酰胺酶活性或2）微生物细胞的腈水解酶活性，将3-羟基戊腈以高产率转化为3-羟基戊酸。 3-羟基戊酸用于制备高支化共聚酯中的ε-己内酯的替代物。