公开(公告)号：US07801271B2

公开(公告)日：2010-09-21

申请号：US12262031

申请日：2008-10-30

申请人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61N5/1037 ,  A61N5/1017 ,  A61N5/103 ,  A61N5/1064 ,  A61N2005/1091

摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.

摘要翻译： 公开了一种用于规划治疗患者眼睛或其附近的视网膜上的病变的方法，代码和系统。 首先建立至少两个光束路径，X射线将沿着该路径被引导到视网膜损伤处。 基于光束的已知光谱和强度特性，确定沿着每个光束路径的照射的总处理时间。 从对准的眼睛位置的视神经的坐标，确定眼睛移动远离对准的患者眼睛位置的方向的程度和持续时间沿着将患者的视神经移动到将在治疗期间允许的照射束的方向 同时仍然将患者视神经的辐射剂量保持在预定剂量水平以下。

公开(公告)号：US20090161826A1

公开(公告)日：2009-06-25

申请号：US12262031

申请日：2008-10-30

申请人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61N5/1037 ,  A61N5/1017 ,  A61N5/103 ,  A61N5/1064 ,  A61N2005/1091

摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.

摘要翻译： 公开了一种用于规划治疗患者眼睛或其附近的视网膜上的病变的方法，代码和系统。 首先建立至少两个光束路径，X射线将沿着该路径被引导到视网膜损伤处。 基于光束的已知光谱和强度特性，确定沿着每个光束路径的照射的总处理时间。 从对准的眼睛位置的视神经的坐标，确定眼睛移动远离对准的患者眼睛位置的方向的程度和持续时间沿着将患者的视神经移动到将在治疗期间允许的照射束的方向 同时仍然将患者视神经的辐射剂量保持在预定剂量水平以下。

公开(公告)号：US08503609B2

公开(公告)日：2013-08-06

申请号：US12877032

申请日：2010-09-07

申请人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61F9/008 ,  A61F2009/00844 ,  A61F2009/00863 ,  A61N5/1017 ,  A61N5/1049 ,  A61N2005/1059 ,  A61N2005/1072 ,  A61N2005/1091

摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.

摘要翻译： 实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。 另外的实施例提供基于图像的方法和系统，用于相对于辐射束轴线对准，跟踪和监测身体部位和治疗目标的运动。 特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用 ，如视网膜的黄斑病变。 描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

公开(公告)号：US08494116B2

公开(公告)日：2013-07-23

申请号：US12887419

申请日：2010-09-21

申请人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61N5/1037 ,  A61N5/1017 ,  A61N5/103 ,  A61N5/1064 ,  A61N2005/1091

摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.

公开(公告)号：US20090161827A1

公开(公告)日：2009-06-25

申请号：US12338634

申请日：2008-12-18

申请人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61F9/008 ,  A61F2009/00844 ,  A61F2009/00863 ,  A61N5/1017 ,  A61N5/1049 ,  A61N2005/1059 ,  A61N2005/1072 ,  A61N2005/1091

摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.

摘要翻译： 实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。 另外的实施例提供基于图像的方法和系统，用于相对于辐射束轴线对准，跟踪和监测身体部位和治疗目标的运动。 特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用 ，如视网膜的黄斑病变。 描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

公开(公告)号：US20110081001A1

公开(公告)日：2011-04-07

申请号：US12887419

申请日：2010-09-21

申请人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61N5/1037 ,  A61N5/1017 ,  A61N5/103 ,  A61N5/1064 ,  A61N2005/1091

摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.

摘要翻译： 公开了一种用于规划治疗患者眼睛或其附近的视网膜上的病变的方法，代码和系统。 首先建立至少两个光束路径，X射线将沿着该路径被引导到视网膜损伤处。 基于光束的已知光谱和强度特性，确定沿着每个光束路径的照射的总处理时间。 从对准的眼睛位置的视神经的坐标，确定眼睛移动远离对准的患者眼睛位置的方向的程度和持续时间沿着将患者的视神经移动到将在治疗期间允许的照射束的方向 同时仍然将患者视神经的辐射剂量保持在预定剂量水平以下。

公开(公告)号：US20110081000A1

公开(公告)日：2011-04-07

申请号：US12877032

申请日：2010-09-07

申请人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61F9/008 ,  A61F2009/00844 ,  A61F2009/00863 ,  A61N5/1017 ,  A61N5/1049 ,  A61N2005/1059 ,  A61N2005/1072 ,  A61N2005/1091

摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.

摘要翻译： 实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。 另外的实施例提供基于图像的方法和系统，用于相对于辐射束轴线对准，跟踪和监测身体部位和治疗目标的运动。 特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用 ，如视网膜的黄斑病变。 描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

公开(公告)号：US07792249B2

公开(公告)日：2010-09-07

申请号：US12338634

申请日：2008-12-18

申请人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61F9/008 ,  A61F2009/00844 ,  A61F2009/00863 ,  A61N5/1017 ,  A61N5/1049 ,  A61N2005/1059 ,  A61N2005/1072 ,  A61N2005/1091

摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.

摘要翻译： 实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。 另外的实施例提供基于图像的方法和系统，用于相对于辐射束轴线对准，跟踪和监测身体部位和治疗目标的运动。 特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用 ，如视网膜的黄斑病变。 描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

公开(公告)号：US08363783B2

公开(公告)日：2013-01-29

申请号：US12103534

申请日：2008-04-15

申请人： Michael Gertner ,  Mark Arnoldussen ,  Matt Herron ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Matt Herron ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61B3/14 ,  A61B3/113 ,  A61B3/12 ,  A61B3/152 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/009 ,  A61F2009/00846 ,  A61F2009/00863 ,  A61N5/1017 ,  A61N5/1049 ,  A61N2005/1059 ,  A61N2005/1091

摘要： Embodiments provide method and systems for determining or measuring objective eye alignment in an external-coordinate system so as to define a reference axis. Additional embodiments provide a method and system of aligning an objectively determined reference axis of the eye in a selected relationship to a therapeutic axis of an ophthalmic therapeutic apparatus and/or a diagnostic axis of an ophthalmic diagnostic apparatus. Embodiments provide a method and system for planning an ophthalmic treatment procedure based on objective eye alignment in an external-coordinate system so as to define a reference axis of an eye to be treated. The reference axis may be used to position a therapeutic energy component, for example, an orthovoltage X-ray treatment device, e.g., positioned to provide treatment to tissue on the retina, such as the macula.

摘要翻译： 实施例提供了用于确定或测量外部坐标系中的客观眼睛对准以便限定参考轴线的方法和系统。 另外的实施例提供了将所选择的眼睛的客观确定的参考轴线与眼科治疗仪器的治疗轴线和/或眼科诊断设备的诊断轴线对准的方法和系统。 实施例提供了一种用于根据外部坐标系中的客观眼睛对准来规划眼科治疗程序以定义要治疗的眼睛的参考轴线的方法和系统。 参考轴可以用于定位治疗能量组分，例如正电压X射线治疗装置，例如定位成为视网膜上的组织（例如黄斑）提供治疗。

公开(公告)号：US20090163898A1

公开(公告)日：2009-06-25

申请号：US12103534

申请日：2008-04-15

申请人： Michael Gertner ,  Mark Arnoldussen ,  Matt Herron ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Matt Herron ,  Junzhong Liang

IPC分类号： A61B3/15 ,  A61B3/14

CPC分类号： A61B3/14 ,  A61B3/113 ,  A61B3/12 ,  A61B3/152 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/009 ,  A61F2009/00846 ,  A61F2009/00863 ,  A61N5/1017 ,  A61N5/1049 ,  A61N2005/1059 ,  A61N2005/1091

摘要： Embodiments provide method and systems for determining or measuring objective eye alignment in an external-coordinate system so as to define a reference axis. Additional embodiments provide a method and system of aligning an objectively determined reference axis of the eye in a selected relationship to a therapeutic axis of an ophthalmic therapeutic apparatus and/or a diagnostic axis of an ophthalmic diagnostic apparatus. Embodiments provide a method and system for planning an ophthalmic treatment procedure based on objective eye alignment in an external-coordinate system so as to define a reference axis of an eye to be treated. The reference axis may be used to position a therapeutic energy component, for example, an orthovoltage X-ray treatment device, e.g., positioned to provide treatment to tissue on the retina, such as the macula.

摘要翻译： 实施例提供了用于确定或测量外部坐标系中的客观眼睛对准以便限定参考轴线的方法和系统。 另外的实施例提供了将所选择的眼睛的客观确定的参考轴线与眼科治疗仪器的治疗轴线和/或眼科诊断设备的诊断轴线对准的方法和系统。 实施例提供了一种用于根据外部坐标系中的客观眼睛对准来规划眼科治疗程序以定义要治疗的眼睛的参考轴线的方法和系统。 参考轴可以用于定位治疗能量组分，例如正电压X射线治疗装置，例如定位成为视网膜上的组织（例如黄斑）提供治疗。