公开(公告)号：US07978818B2

公开(公告)日：2011-07-12

申请号：US12493136

申请日：2009-06-26

申请人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Mark Arnoldussen ,  Matt Herron

发明人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Mark Arnoldussen ,  Matt Herron

IPC分类号： A61N5/10 ,  G21K5/08 ,  A61B6/08

CPC分类号： A61N5/1067 ,  A61B6/506 ,  A61B6/508 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1017 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1019 ,  A61N2005/1022 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1091 ,  A61N2005/1097

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilised in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施方案中，身体的其它病症或组织用辐射剂量治疗。 在一些实施例中，目标组织基于眼睛成像被放置在全局坐标系中。 在一些实施例中，全局坐标系统内的目标组织导致基于坐标系统内的目标组织定向的自动定位系统的方向。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施方案中，使用基准标记来鉴定靶组织的位置。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US20100172473A1

公开(公告)日：2010-07-08

申请号：US12725406

申请日：2010-03-16

申请人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

发明人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system. In some embodiments, the eye is held in place and in some embodiments, the eye is fixed by the patient. In some embodiments, a fiducial is placed on the eye to aid in positioning. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，将眼部结构置于基于眼睛成像的全局坐标系中。 在一些实施例中，全局坐标系内的目镜结构导致基于坐标系内的眼睛结构而被引导的自动定位系统的方向。 在一些实施例中，跟踪眼结构的位置并且与放射外科手术系统的状态相关。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施例中，结构是眼睛，并且眼睛被系统跟踪。 在一些实施例中，眼睛被保持就位，并且在一些实施例中，眼睛被患者固定。 在一些实施例中，将基准置于眼睛上以帮助定位。 在一些实施例中，使用眼睛的反射来帮助定位。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US20090182310A1

公开(公告)日：2009-07-16

申请号：US12027069

申请日：2008-02-06

申请人： Michael Gertner ,  Mark Arnoldussen ,  Matt Herron

发明人： Michael Gertner ,  Mark Arnoldussen ,  Matt Herron

IPC分类号： A61F9/00 ,  A61N5/10

CPC分类号： A61N5/1017 ,  A61B17/0231 ,  A61F9/008 ,  A61F9/00804 ,  A61F9/00819 ,  A61F9/00821 ,  A61F9/009 ,  A61F2009/00863 ,  A61F2009/00865 ,  A61F2009/00872 ,  A61F2009/00895

摘要： A method and system for performing an ocular irradiation procedure on a patient's eye is disclosed. The system includes a head support for supporting the patient's head, an eye-contact device attachable to the front portion of the patient's eye, to stabilize the position of the eye; and a position detector for determining the position of the contact device in the external coordinate system. A source of a collimated electromagnetic radiation beam in the system is controlled by a beam-positioning assembly for positioning the beam source such that the beam, when activated, is aimed along a selected path at a selected coordinate in the external coordinate system corresponding to a selected target region in the patient's eye.

摘要翻译： 公开了一种对患者眼睛进行眼部照射手术的方法和系统。 该系统包括用于支撑患者头部的头部支撑件，可附接到患者眼睛前部的眼睛接触装置，以稳定眼睛的位置; 以及位置检测器，用于确定接触装置在外部坐标系中的位置。 系统中的准直电磁辐射束的源由用于定位光束源的光束定位组件控制，使得当被激活时该光束沿着选定的路径被瞄准在对应于外部坐标系的外部坐标系中的选定坐标 在患者眼睛中选择的目标区域。

公开(公告)号：US20060264917A1

公开(公告)日：2006-11-23

申请号：US11134861

申请日：2005-05-20

申请人： Kuang-mon Tuan ,  Mark Arnoldussen ,  Gunagming Dai ,  Kingman Yee

发明人： Kuang-mon Tuan ,  Mark Arnoldussen ,  Gunagming Dai ,  Kingman Yee

IPC分类号： A61B18/18

CPC分类号： G02C7/021 ,  A61B3/0025 ,  A61F9/00806 ,  A61F9/00808 ,  A61F9/00817 ,  A61F2009/00844 ,  A61F2009/00872 ,  A61F2009/0088 ,  A61F2009/00895 ,  G02C7/04 ,  G02C7/048 ,  G02C2202/22

摘要： Methods and systems can correct aberrations and/or verify various procedures used to correct aberrations in the eye. One embodiment provides a method for verifying vision correction for a patient's eye comprising measuring irregular aberrations of the eye and determining a proposed refractive correction for treatment of the eye. A central portion of a verification lens is configured so that the central portion corresponds with the proposed correction. The verification lens is then registered with the eye by positioning a peripheral portion of the verification lens upon the sclera so that the central portion is optically aligned with the aberrations. Then a determination is made whether a corrected vision of the eye with the verification lens is acceptable so as to verify the proposed correction.

摘要翻译： 方法和系统可以校正像差和/或验证用于校正眼睛中的像差的各种程序。 一个实施例提供了一种用于验证患者眼睛的视力矫正的方法，包括测量眼睛的不规则像差并确定用于治疗眼睛的所提出的屈光矫正。 验证透镜的中心部分被配置为使得中心部分对应于所提出的校正。 然后通过将验证透镜的周边部分定位在巩膜上，使验证透镜与眼睛对准，使得中心部分与像差光学对准。 然后确定用验证透镜的眼睛的校正视力是否可接受，以便验证所提出的校正。

公开(公告)号：US08363783B2

公开(公告)日：2013-01-29

申请号：US12103534

申请日：2008-04-15

申请人： Michael Gertner ,  Mark Arnoldussen ,  Matt Herron ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Matt Herron ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61B3/14 ,  A61B3/113 ,  A61B3/12 ,  A61B3/152 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/009 ,  A61F2009/00846 ,  A61F2009/00863 ,  A61N5/1017 ,  A61N5/1049 ,  A61N2005/1059 ,  A61N2005/1091

摘要： Embodiments provide method and systems for determining or measuring objective eye alignment in an external-coordinate system so as to define a reference axis. Additional embodiments provide a method and system of aligning an objectively determined reference axis of the eye in a selected relationship to a therapeutic axis of an ophthalmic therapeutic apparatus and/or a diagnostic axis of an ophthalmic diagnostic apparatus. Embodiments provide a method and system for planning an ophthalmic treatment procedure based on objective eye alignment in an external-coordinate system so as to define a reference axis of an eye to be treated. The reference axis may be used to position a therapeutic energy component, for example, an orthovoltage X-ray treatment device, e.g., positioned to provide treatment to tissue on the retina, such as the macula.

摘要翻译： 实施例提供了用于确定或测量外部坐标系中的客观眼睛对准以便限定参考轴线的方法和系统。 另外的实施例提供了将所选择的眼睛的客观确定的参考轴线与眼科治疗仪器的治疗轴线和/或眼科诊断设备的诊断轴线对准的方法和系统。 实施例提供了一种用于根据外部坐标系中的客观眼睛对准来规划眼科治疗程序以定义要治疗的眼睛的参考轴线的方法和系统。 参考轴可以用于定位治疗能量组分，例如正电压X射线治疗装置，例如定位成为视网膜上的组织（例如黄斑）提供治疗。

公开(公告)号：US08295437B2

公开(公告)日：2012-10-23

申请号：US13180457

申请日：2011-07-11

申请人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Mark Arnoldussen ,  Matt Herron

发明人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Mark Arnoldussen ,  Matt Herron

IPC分类号： A61N5/10 ,  G21K5/08 ,  A61B6/08

CPC分类号： A61N5/1067 ,  A61B6/506 ,  A61B6/508 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1017 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1019 ,  A61N2005/1022 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1091 ,  A61N2005/1097

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

公开(公告)号：US08073105B2

公开(公告)日：2011-12-06

申请号：US12725406

申请日：2010-03-16

申请人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

发明人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system. In some embodiments, the eye is held in place and in some embodiments, the eye is fixed by the patient. In some embodiments, a fiducial is placed on the eye to aid in positioning. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，将眼部结构置于基于眼睛成像的全局坐标系中。 在一些实施例中，全局坐标系内的目镜结构导致基于坐标系内的眼睛结构而被引导的自动定位系统的方向。 在一些实施例中，跟踪眼结构的位置并且与放射外科手术系统的状态相关。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施例中，结构是眼睛，并且眼睛被系统跟踪。 在一些实施例中，眼睛被保持就位，并且在一些实施例中，眼睛被患者固定。 在一些实施例中，将基准置于眼睛上以帮助定位。 在一些实施例中，使用眼睛的反射来帮助定位。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US20090161827A1

公开(公告)日：2009-06-25

申请号：US12338634

申请日：2008-12-18

申请人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61F9/008 ,  A61F2009/00844 ,  A61F2009/00863 ,  A61N5/1017 ,  A61N5/1049 ,  A61N2005/1059 ,  A61N2005/1072 ,  A61N2005/1091

摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.

摘要翻译： 实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。 另外的实施例提供基于图像的方法和系统，用于相对于辐射束轴线对准，跟踪和监测身体部位和治疗目标的运动。 特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用 ，如视网膜的黄斑病变。 描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

公开(公告)号：US07479138B2

公开(公告)日：2009-01-20

申请号：US11174279

申请日：2005-06-30

申请人： David Hindi ,  Keith Holliday ,  Mark Arnoldussen

发明人： David Hindi ,  Keith Holliday ,  Mark Arnoldussen

IPC分类号： A61F9/008

CPC分类号： H01S3/1305 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00817 ,  A61F2009/00846 ,  A61F2009/00855 ,  A61F2009/00872 ,  A61N2005/067 ,  H01S3/005 ,  H01S5/0071 ,  H01S5/0683

摘要： Devices, systems, and methods for measuring and determining positions of light energy having wavelengths of less than (as well as equal to or greater than) 200 nm, and are particularly well suited for measuring pulsed light at ultraviolet and other wavelengths using position sensing diode (PSD) technology. An integrator may sum a total charge of a signal from the PSD. Correlations between a distribution of integrated charges among electrodes of the PSD may be non-linear, and may benefit from adjustment for different overall pulse light quantities and/or spot sizes.

摘要翻译： 用于测量和确定具有小于（以及等于或大于）200nm的波长的光能的位置的装置，系统和方法，并且特别适用于使用位置感测二极管测量紫外线和其他波长的脉冲光 （PSD）技术。 积分器可以对来自PSD的信号的总电荷求和。 在PSD的电极之间的积分电荷的分布之间的相关性可以是非线性的，并且可以受益于对于不同的总脉冲光量和/或光斑尺寸的调整。

公开(公告)号：US20060084955A1

公开(公告)日：2006-04-20

申请号：US11174279

申请日：2005-06-30

申请人： David Hindi ,  Keith Holliday ,  Mark Arnoldussen

发明人： David Hindi ,  Keith Holliday ,  Mark Arnoldussen

IPC分类号： A61B18/18 ,  A61F9/008

CPC分类号： H01S3/1305 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00817 ,  A61F2009/00846 ,  A61F2009/00855 ,  A61F2009/00872 ,  A61N2005/067 ,  H01S3/005 ,  H01S5/0071 ,  H01S5/0683

摘要： Devices, systems, and methods for measuring and determining positions of light energy having wavelengths of less than (as well as equal to or greater than) 200 nm, and are particularly well suited for measuring pulsed light at ultraviolet and other wavelengths using position sensing diode (PSD) technology. An integrator may sum a total charge of a signal from the PSD. Correlations between a distribution of integrated charges among electrodes of the PSD may be non-linear, and may benefit from adjustment for different overall pulse light quantities and/or spot sizes.