公开(公告)号：US07978818B2

公开(公告)日：2011-07-12

申请号：US12493136

申请日：2009-06-26

申请人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Mark Arnoldussen ,  Matt Herron

发明人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Mark Arnoldussen ,  Matt Herron

IPC分类号： A61N5/10 ,  G21K5/08 ,  A61B6/08

CPC分类号： A61N5/1067 ,  A61B6/506 ,  A61B6/508 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1017 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1019 ,  A61N2005/1022 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1091 ,  A61N2005/1097

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilised in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施方案中，身体的其它病症或组织用辐射剂量治疗。 在一些实施例中，目标组织基于眼睛成像被放置在全局坐标系中。 在一些实施例中，全局坐标系统内的目标组织导致基于坐标系统内的目标组织定向的自动定位系统的方向。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施方案中，使用基准标记来鉴定靶组织的位置。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US07912179B2

公开(公告)日：2011-03-22

申请号：US12142718

申请日：2008-06-19

申请人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Matt Herron

发明人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Matt Herron

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61B6/506 ,  A61B6/508 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1017 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1019 ,  A61N2005/1022 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1091 ,  A61N2005/1097

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, an eye is held with force and in alignment with the system. In some embodiments, the device automatically turns off with excessive movement outside of alignment along an axis of the eye. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施方案中，身体的其它病症或组织用辐射剂量治疗。 在一些实施例中，目标组织基于眼睛成像被放置在全局坐标系中。 在一些实施例中，全局坐标系统内的目标组织导致基于坐标系统内的目标组织定向的自动定位系统的方向。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施方案中，使用基准标记来鉴定靶组织的位置。 在一些实施例中，眼睛被保持并且与系统对准。 在一些实施例中，设备沿着眼睛的轴线的对准内部的过度运动自动关闭。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US20100172473A1

公开(公告)日：2010-07-08

申请号：US12725406

申请日：2010-03-16

申请人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

发明人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system. In some embodiments, the eye is held in place and in some embodiments, the eye is fixed by the patient. In some embodiments, a fiducial is placed on the eye to aid in positioning. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，将眼部结构置于基于眼睛成像的全局坐标系中。 在一些实施例中，全局坐标系内的目镜结构导致基于坐标系内的眼睛结构而被引导的自动定位系统的方向。 在一些实施例中，跟踪眼结构的位置并且与放射外科手术系统的状态相关。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施例中，结构是眼睛，并且眼睛被系统跟踪。 在一些实施例中，眼睛被保持就位，并且在一些实施例中，眼睛被患者固定。 在一些实施例中，将基准置于眼睛上以帮助定位。 在一些实施例中，使用眼睛的反射来帮助定位。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US08442185B2

公开(公告)日：2013-05-14

申请号：US13069236

申请日：2011-03-22

申请人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Matt Herron

发明人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Matt Herron

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61B6/506 ,  A61B6/508 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1017 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1019 ,  A61N2005/1022 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1091 ,  A61N2005/1097

摘要： A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，眼睛结构被放置在基于眼睛成像的全局坐标系中，其导致自动定位系统的方向。 在一些实施例中，追踪眼结构的位置并与放射外科系统有关。 在一些实施方案中，治疗计划用于待治疗的特定疾病和/或要避免的结构。 在一些实施例中，基准有助于定位系统。 在一些实施例中，使用眼睛的反射来帮助定位。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US08837675B2

公开(公告)日：2014-09-16

申请号：US13311372

申请日：2011-12-05

申请人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

发明人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，眼睛结构被放置在基于眼睛成像的全局坐标系中，其导致自动定位系统的方向。 在一些实施例中，追踪眼结构的位置并与放射外科系统有关。 在一些实施方案中，治疗计划用于待治疗的特定疾病和/或要避免的结构。 在一些实施例中，基准有助于定位系统。 在一些实施例中，使用眼睛的反射来帮助定位。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US08503609B2

公开(公告)日：2013-08-06

申请号：US12877032

申请日：2010-09-07

申请人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

发明人： Michael Gertner ,  Mark Arnoldussen ,  Erik Chell ,  Steven D. Hansen ,  Matt Herron ,  Igor Koruga ,  Junzhong Liang

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61F9/008 ,  A61F2009/00844 ,  A61F2009/00863 ,  A61N5/1017 ,  A61N5/1049 ,  A61N2005/1059 ,  A61N2005/1072 ,  A61N2005/1091

摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.

摘要翻译： 实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。 另外的实施例提供基于图像的方法和系统，用于相对于辐射束轴线对准，跟踪和监测身体部位和治疗目标的运动。 特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用 ，如视网膜的黄斑病变。 描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

公开(公告)号：US20110170664A1

公开(公告)日：2011-07-14

申请号：US13069236

申请日：2011-03-22

申请人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Matt Herron

发明人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Matt Herron

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61B6/506 ,  A61B6/508 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1017 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1019 ,  A61N2005/1022 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1091 ,  A61N2005/1097

摘要： A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，眼睛结构被放置在基于眼睛成像的全局坐标系中，其导致自动定位系统的方向。 在一些实施例中，追踪眼结构的位置并与放射外科系统有关。 在一些实施方案中，治疗计划用于待治疗的特定疾病和/或要避免的结构。 在一些实施例中，基准有助于定位系统。 在一些实施例中，使用眼睛的反射来帮助定位。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US07680244B2

公开(公告)日：2010-03-16

申请号：US11873386

申请日：2007-10-16

申请人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

发明人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，眼睛结构被放置在基于眼睛成像的全局坐标系中，其导致自动定位系统的方向。 在一些实施例中，追踪眼结构的位置并与放射外科系统有关。 在一些实施方案中，治疗计划用于待治疗的特定疾病和/或要避免的结构。 在一些实施例中，基准有助于定位系统。 在一些实施例中，使用眼睛的反射来帮助定位。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US08295437B2

公开(公告)日：2012-10-23

申请号：US13180457

申请日：2011-07-11

申请人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Mark Arnoldussen ,  Matt Herron

发明人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Mark Arnoldussen ,  Matt Herron

IPC分类号： A61N5/10 ,  G21K5/08 ,  A61B6/08

CPC分类号： A61N5/1067 ,  A61B6/506 ,  A61B6/508 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1017 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1019 ,  A61N2005/1022 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1091 ,  A61N2005/1097

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

公开(公告)号：US08073105B2

公开(公告)日：2011-12-06

申请号：US12725406

申请日：2010-03-16

申请人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

发明人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system. In some embodiments, the eye is held in place and in some embodiments, the eye is fixed by the patient. In some embodiments, a fiducial is placed on the eye to aid in positioning. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，将眼部结构置于基于眼睛成像的全局坐标系中。 在一些实施例中，全局坐标系内的目镜结构导致基于坐标系内的眼睛结构而被引导的自动定位系统的方向。 在一些实施例中，跟踪眼结构的位置并且与放射外科手术系统的状态相关。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施例中，结构是眼睛，并且眼睛被系统跟踪。 在一些实施例中，眼睛被保持就位，并且在一些实施例中，眼睛被患者固定。 在一些实施例中，将基准置于眼睛上以帮助定位。 在一些实施例中，使用眼睛的反射来帮助定位。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。