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公开(公告)号：US4743450A
公开(公告)日：1988-05-10
申请号：US17962
申请日：1987-02-24
申请人： Michael Harris , Gerard Hokanson , Kuchi Murthy , Robert Reisch , Frank Waldman
发明人： Michael Harris , Gerard Hokanson , Kuchi Murthy , Robert Reisch , Frank Waldman
IPC分类号： A61K45/08 , A61K9/20 , A61K31/40 , A61K31/401 , A61K31/445 , A61K38/00 , A61K38/55 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/26 , A61P43/00 , C07D207/16 , C07D211/32 , A61K31/195 , A61K31/27 , A61K31/505
CPC分类号： A61K31/40 , A61K38/005 , A61K38/556 , A61K47/02 , A61K47/26 , A61K9/2009 , A61K9/2018
摘要： The cyclization, hydrolysis, and coloration of certain ACE inhibitors is minimized when they are formulated with a metal-containing stabilizer and a saccharide.
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公开(公告)号：US4793998A
公开(公告)日：1988-12-27
申请号：US921931
申请日：1986-10-20
申请人： Kuchi S. Murthy , Michael R. Harris , Gerard C. Hokanson , Robert G. Reisch, Jr. , Frank Waldman , Mahdi B. Fawzi
发明人： Kuchi S. Murthy , Michael R. Harris , Gerard C. Hokanson , Robert G. Reisch, Jr. , Frank Waldman , Mahdi B. Fawzi
IPC分类号： A61K45/08 , A61K31/40 , A61K31/401 , A61K31/44 , A61K31/47 , A61K47/00 , A61K47/12 , A61K47/22 , A61P9/12 , A61P43/00 , A61K9/68 , A61K31/195 , A61K31/27
CPC分类号： A61K47/22 , A61K31/40 , A61K31/44 , A61K47/12 , Y10S514/97
摘要： The cyclization and hydrolysis of certain ACE inhibitors is minimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.
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公开(公告)号：US4830853A
公开(公告)日：1989-05-16
申请号：US921717
申请日：1986-10-20
申请人： Kuchi S. Murthy , Michael R. Harris , Gerard C. Hokanson , Robert G. Reisch, Jr. , Mahdi B. Fawzi , Frank Waldman
发明人： Kuchi S. Murthy , Michael R. Harris , Gerard C. Hokanson , Robert G. Reisch, Jr. , Mahdi B. Fawzi , Frank Waldman
IPC分类号： A61K45/08 , A61K31/40 , A61K31/401 , A61K31/44 , A61K31/47 , A61K47/00 , A61K47/12 , A61K47/22 , A61P9/12 , A61P43/00
摘要： The oxidation--and color-stability of certain ace inhibitors is optimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.
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