公开(公告)号：US4743450A

公开(公告)日：1988-05-10

申请号：US17962

申请日：1987-02-24

申请人： Michael Harris ,  Gerard Hokanson ,  Kuchi Murthy ,  Robert Reisch ,  Frank Waldman

发明人： Michael Harris ,  Gerard Hokanson ,  Kuchi Murthy ,  Robert Reisch ,  Frank Waldman

IPC分类号： A61K45/08 ,  A61K9/20 ,  A61K31/40 ,  A61K31/401 ,  A61K31/445 ,  A61K38/00 ,  A61K38/55 ,  A61K47/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61P43/00 ,  C07D207/16 ,  C07D211/32 ,  A61K31/195 ,  A61K31/27 ,  A61K31/505

CPC分类号： A61K31/40 ,  A61K38/005 ,  A61K38/556 ,  A61K47/02 ,  A61K47/26 ,  A61K9/2009 ,  A61K9/2018

摘要： The cyclization, hydrolysis, and coloration of certain ACE inhibitors is minimized when they are formulated with a metal-containing stabilizer and a saccharide.

公开(公告)号：US20060106057A1

公开(公告)日：2006-05-18

申请号：US11313123

申请日：2005-12-15

申请人： Jane Daniel ,  Michael Harris ,  Gerard Hokanson ,  Jay Weiss

发明人： Jane Daniel ,  Michael Harris ,  Gerard Hokanson ,  Jay Weiss

IPC分类号： A61K31/47

CPC分类号： A61K45/06 ,  A61K9/1611 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2068 ,  A61K31/47 ,  A61K31/472 ,  A61K31/475 ,  A61K33/08 ,  A61K47/02 ,  A61K47/26 ,  A61K2300/00

摘要： The present invention is directed to ACE inhibitor-containing compositions stabilized by the presence of magnesium oxide. Preferably, the ACE inhibitor, quinapril, is protected from certain forms of degradation when prepared in a pharmaceutical composition consisting essentially of magnesium oxide as the stabilizing agent. The presence of magnesium oxide also lends itself to favorable processing conditions during the manufacture of ACE inhibitor-containing compositions, especially processing by wet granulation.