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1.发明授权公开(公告)号：US08980308B2
公开(公告)日：2015-03-17
申请号：US10568941
申请日：2004-08-14
申请人： Michael Horstmann , Frank Theobald
发明人： Michael Horstmann , Frank Theobald
IPC分类号： A61K9/70 , A61K31/13 , A61K31/381 , A61K31/428 , A61K45/06
CPC分类号： A61K9/7092 , A61K31/13 , A61K31/381 , A61K31/428 , A61K45/06 , A61K2300/00
摘要： The transdermal pharmaceutical preparations for the treatment of Parkinson's disease contain a combination of at least two active substances selected from the following groups of active substances: dopamine agonists and L-dopa, monoamine oxidase inhibitors, anticholinergics, NMDA-receptor antagonists, sympathomimetics; at least two of the said active substances being members of different active substance groups.
摘要翻译： 用于治疗帕金森病的透皮药物制剂含有选自下列活性物质组的至少两种活性物质的组合：多巴胺激动剂和左旋多巴，单胺氧化酶抑制剂，抗胆碱能药，NMDA-受体拮抗剂，拟交感神经药; 所述活性物质中的至少两种是不同活性物质基团的成员。
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2.发明申请Medicament preparations for transdermal application containing active ingredient combinations for treating parkinson's disease 有权用于经皮应用的药物制剂，含有用于治疗帕金森病的活性成分组合公开(公告)号：US20070026054A1
公开(公告)日：2007-02-01
申请号：US10568941
申请日：2004-08-14
申请人： Frank Theobald , Michael Horstmann
发明人： Frank Theobald , Michael Horstmann
IPC分类号： A61K31/538 , A61K31/498 , A61K31/48 , A61K31/46 , A61K31/137 , A61K31/198 , A61F13/02
CPC分类号： A61K9/7092 , A61K31/13 , A61K31/381 , A61K31/428 , A61K45/06 , A61K2300/00
摘要： Transdermal pharmaceutical preparations for the treatment of Parkinson's disease containing a combination of at least two active substances selected from the following groups of active substances: dopamine agonists and L-dopa, monoamine oxidase inhibitors, anticholinergics, NMDA-receptor antagonists, sympathomimetics; at least two of the said active substances being members of different active substance groups.
摘要翻译： 用于治疗帕金森病的透皮药物制剂，其含有选自以下活性物质组的至少两种活性物质的组合：多巴胺激动剂和左旋多巴，单胺氧化酶抑制剂，抗胆碱能药，NMDA-受体拮抗剂，拟交感神经药; 所述活性物质中的至少两种是不同活性物质基团的成员。
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公开(公告)号：US20100047322A1
公开(公告)日：2010-02-25
申请号：US12308311
申请日：2007-06-04
IPC分类号： A61K9/70 , A61K31/437 , A61K31/522 , A61K31/549 , A61K31/138 , A61K31/404 , A61K31/517 , A61K31/55 , A61K31/551 , A61K31/675 , A61P9/12
CPC分类号： A61K45/06 , A61K9/006 , A61K9/7007 , A61K31/00 , A61K2300/00
摘要： Sheet-like dosage forms that quickly dissolve or disintegrate in an aqueous environment, for the application of active agent combinations for the treatment of hypertension. The dosage forms contain at least two active agents that are suitable for the treatment of hypertension. The antihypertensive agents are selected from the group that encompasses beta receptor blockers, alpha receptor blockers, calcium antagonists, ACE inhibitors, AT1 antagonists, centrally acting antihypertensive agents, direct vasodilators, and diuretics. The use of active agent combinations according to the invention for the production of an oral dosage form for the treatment of high blood pressure, a method for the therapeutic treatment of hypertension, and a method for the production of a sheet-like dosage form are also disclosed.
摘要翻译： 在水性环境中快速溶解或分解的片状剂型，用于施用活性剂组合以治疗高血压。 剂型含有至少两种适用于治疗高血压的活性剂。 抗高血压剂选自包括β受体阻断剂，α受体阻断剂，钙拮抗剂，ACE抑制剂，AT1拮抗剂，中枢作用的抗高血压药，直接血管扩张剂和利尿剂的组。 根据本发明的活性剂组合用于生产用于治疗高血压的口服剂型，高血压治疗性治疗方法和片状剂型的制备方法也是 披露
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公开(公告)号：US20090291123A1
公开(公告)日：2009-11-26
申请号：US12308208
申请日：2007-06-04
CPC分类号： A61K9/006 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0056 , A61K31/19 , A61K31/196 , A61K31/485 , A61K31/515 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： Sheet-like dosage forms for pain therapy, based on hydrophilic polymers, which rapidly dissolve or disintegrate in an aqueous environment and which release active agent combinations when placed into a body orifice or body cavity, and which are preferably orally administrable, with the dosage form containing an active agent combination consisting of an opioid and a second substance The second active agent is a non-steroidal anti-rheumatic (NSAR) or an antidepressant.
摘要翻译： 用于疼痛治疗的片状剂型，其基于亲水性聚合物，其在水性环境中快速溶解或崩解，并且当放入身体孔或体腔中时释放活性剂组合，并且其优选可口服给药， 含有由阿片样物质和第二物质组成的活性剂组合物。第二种活性剂是非类固醇抗风湿剂（NSAR）或抗抑郁药。
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公开(公告)号：US20090203670A1
公开(公告)日：2009-08-13
申请号：US12308194
申请日：2007-06-04
IPC分类号： A61K31/55 , A61K31/5375 , A61K31/497 , A61K31/519
CPC分类号： A61K45/06 , A61K9/006 , A61K9/7007 , A61K31/00 , A61K2300/00
摘要： A sheet-like pharmaceutical preparation (dosage form) that quickly disintegrates on contact with moisture, based on hydrophilic polymers for the release of at least one active agent. The dosage form contains an active agent combination for treating depression, and at least one active agent selected from the antidepressant group of drugs. In addition, the use of such a combination of active agents for the production of an orally administrable pharmaceutical product for the treatment of depression, and the therapeutic treatment of depression by oral administration of one of the named pharmaceutical preparations, is provided.
摘要翻译： 基于用于释放至少一种活性剂的亲水性聚合物，其与水分接触快速崩解的片状药物制剂（剂型）。 剂型含有用于治疗抑郁症的活性剂组合物和选自抗抑郁药物组的至少一种活性剂。 此外，提供了这样的活性剂组合用于生产用于治疗抑郁症的可口服给药的药物产品，以及通过口服给药所述药物制剂之一来治疗抑郁症。
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6.发明申请Dermal or transdermal therapeutic system comprising an ormocer with barrier effect on a cover foil 审中-公开皮肤或透皮治疗系统包括在覆盖箔上具有屏障作用的ormocer公开(公告)号：US20060210615A1
公开(公告)日：2006-09-21
申请号：US10567077
申请日：2004-07-23
申请人： Frank Theobald , Notger Weber , Simon Günter
发明人： Frank Theobald , Notger Weber , Simon Günter
IPC分类号： A61K9/70
摘要： The invention relates to a dermal or transdermal therapeutic system comprising a cover foil with barrier effect against gas, odour and volatile light substances. Said invention is characterised in that the cover foil is provided with at least one substrate and with at least one layer consisting of an inorganic-organic hybrid polymer (Ormocer).
摘要翻译： 本发明涉及一种皮肤或透皮治疗系统，其包括对气体，气味和挥发性光物质具有阻隔作用的覆盖箔。 本发明的特征在于，覆盖箔具有至少一个基底和至少一层由无机 - 有机杂化聚合物（Ormocer）组成的层。
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公开(公告)号：US20130266633A1
公开(公告)日：2013-10-10
申请号：US13906922
申请日：2013-05-31
CPC分类号： A61K9/7084 , A61K9/7061 , A61K31/27
摘要： The present invention relates to Transdermal Therapeutic Systems having a silicone adhesive layer, to Transdermal Therapeutic Systems providing specific plasma concentrations, to their manufacture and use.
摘要翻译： 本发明涉及具有硅氧烷粘合剂层，提供特定血浆浓度的透皮治疗系统的透皮治疗系统，用于其制造和使用。
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公开(公告)号：US20090274732A1
公开(公告)日：2009-11-05
申请号：US12308242
申请日：2007-06-04
IPC分类号： A61K9/00 , A61K31/165 , A61P3/10
CPC分类号： A61K45/06 , A61K9/0056 , A61K9/006 , A61K31/155 , A61K31/198 , A61K31/64 , A61K2300/00
摘要： Rapidly disintegrating oral dosage forms for the application of active agent combinations for diabetes therapy. The dosage forms contain at least two active agents suitable for treating type-2 diabetes. The antidiabetic active agents are selected from the group comprising sulfonylureas, glitazones, glinides, biguanides, and absorption-delaying agents. The use of the active agent combination to produce an oral dosage form for the treatment of diabetes, a method for the therapeutic treatment of diabetes, and a method for the production of a sheet-like dosage form are also disclosed.
摘要翻译： 用于糖尿病治疗的活性药物组合的快速崩解口服剂型。 剂型含有至少两种适用于治疗2型糖尿病的活性剂。 抗糖尿病活性剂选自磺酰脲类，格列酮，格列奈类，双胍类和吸收延缓剂。 还公开了使用活性剂组合产生用于治疗糖尿病的口服剂型，糖尿病治疗性治疗方法和片状剂型的制备方法。
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公开(公告)号：US20070128263A1
公开(公告)日：2007-06-07
申请号：US11539979
申请日：2006-10-10
申请人： Paul Gargiulo , Roger Lane , Beatrix Platt , Frank Theobald , Bettina Wall
发明人： Paul Gargiulo , Roger Lane , Beatrix Platt , Frank Theobald , Bettina Wall
IPC分类号： A61K9/70
CPC分类号： A61K9/7084 , A61K9/7061 , A61K31/27
摘要： The present invention relates to Transdermal Therapeutic Systems having a silicone adhesive layer, to Transdermal Therapeutic Systems providing specific plasma concentrations, to their manufacture and use.
摘要翻译： 本发明涉及具有硅氧烷粘合剂层的透皮治疗系统，其提供特定血浆浓度的透皮治疗系统，用于其制造和使用。
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公开(公告)号：US20060182791A1
公开(公告)日：2006-08-17
申请号：US10564932
申请日：2004-07-14
申请人： Frank Theobald , Wolfgang Laux , Beatrix Platt , Regine Kaufmann
发明人： Frank Theobald , Wolfgang Laux , Beatrix Platt , Regine Kaufmann
IPC分类号： A61K31/428 , A61K9/70
CPC分类号： A61K9/7061 , A61K31/428
摘要： The invention relates to a transdermal therapeutic system (TTS) releasing an active pramipexol agent during a time ranging from 4 to 7 hours.
摘要翻译： 本发明涉及在4至7小时的时间内释放活性的普立立姆剂的透皮治疗系统（TTS）。
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