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公开(公告)号：US07745639B2
公开(公告)日：2010-06-29
申请号：US10506702
申请日：2003-03-04
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , J. Christopher Culberson , George D. Hartman , Brenda J. Mariano , Maricel Torrent
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , J. Christopher Culberson , George D. Hartman , Brenda J. Mariano , Maricel Torrent
IPC分类号： C07D231/06 , A01N43/56
CPC分类号： C07D401/04 , C04B35/632 , C07D231/06 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04
摘要： The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的二氢吡唑化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07235580B2
公开(公告)日：2007-06-26
申请号：US10531495
申请日：2003-10-14
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , George D. Hartman , Brenda J. Mariano
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , George D. Hartman , Brenda J. Mariano
IPC分类号： A61K31/4025 , A61K31/4439 , C07D401/02 , C07D207/20 , C07D413/02
CPC分类号： C07D405/12 , C07D207/20 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US08710076B2
公开(公告)日：2014-04-29
申请号：US13124901
申请日：2009-10-15
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Izzat T. Raheem , Anthony J. Roecker , John D. Schreier
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Izzat T. Raheem , Anthony J. Roecker , John D. Schreier
IPC分类号： A61K31/47 , C07D401/14
CPC分类号： A61K31/445 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2,5-二取代的哌啶酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20110251237A1
公开(公告)日：2011-10-13
申请号：US13124897
申请日：2009-10-15
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , John D. Schreier , David B. Whitman
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , John D. Schreier , David B. Whitman
IPC分类号： A61K31/4709 , A61P3/04 , A61K31/4439 , C07D401/10 , C07D215/24
CPC分类号： C07D413/14 , C07D401/10 , C07D401/14 , C07D417/14
摘要： The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2,5-二取代的哌啶酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20090192143A1
公开(公告)日：2009-07-30
申请号：US12309239
申请日：2007-07-13
IPC分类号： A61K31/551 , C07D413/14 , A61P3/04
CPC分类号： C07D413/14 , C07D403/14 , C07D417/14
摘要： The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的取代的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US08569311B2
公开(公告)日：2013-10-29
申请号：US13568242
申请日：2012-08-07
IPC分类号： C07D401/14 , A61K31/4525
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to pyridyl piperidine compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的吡啶基哌啶化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US08492392B2
公开(公告)日：2013-07-23
申请号：US13320038
申请日：2010-05-24
IPC分类号： A61K31/519
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention is directed to alkoxy tetrahydro-pyridopyrimidine compounds of formula I, which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
摘要翻译： 本发明涉及式I的烷氧基四氢 - 吡啶并嘧啶化合物，其可用作治疗与磷酸二酯酶10（PDE10）相关的中枢神经系统疾病的治疗剂。 本发明还涉及这些化合物用于治疗神经和精神疾病如精神分裂症，精神病或亨廷顿病以及与纹状体功能减退或基底神经节功能障碍相关的疾病的用途。
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公开(公告)号：US20120065211A1
公开(公告)日：2012-03-15
申请号：US13320038
申请日：2010-05-24
IPC分类号： A61K31/519 , A61P25/22 , A61P25/18 , C07D471/04 , A61P25/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention is directed to alkoxy tetrahydro-pyridopyrimidine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
摘要翻译： 本发明涉及可用作治疗与磷酸二酯酶10（PDE10）相关的中枢神经系统疾病的治疗剂的烷氧基四氢 - 吡啶并嘧啶化合物。 本发明还涉及这些化合物用于治疗神经和精神疾病如精神分裂症，精神病或亨廷顿病以及与纹状体功能减退或基底神经节功能障碍相关的疾病的用途。
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公开(公告)号：US20110195957A1
公开(公告)日：2011-08-11
申请号：US13089677
申请日：2011-04-19
申请人： Jeffrey M. Bergman , Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Swati P. Mercer , Anthony J. Roecker
发明人： Jeffrey M. Bergman , Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Swati P. Mercer , Anthony J. Roecker
IPC分类号： A61K31/551 , C07D413/14 , C07D495/04 , C07D403/14 , C07D491/044 , C07D487/04 , A61P25/00 , A61P25/18 , A61P25/16 , A61P25/08 , A61P29/00 , A61P3/04
CPC分类号： C07D413/14 , C07D401/14 , C07D403/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
摘要： The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲肽受体的拮抗剂的取代的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US07951797B2
公开(公告)日：2011-05-31
申请号：US11998812
申请日：2007-11-30
IPC分类号： A61P25/20 , A61K31/551 , C07D243/08
CPC分类号： C07D413/14 , C07D401/14 , C07D403/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
摘要： The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的取代的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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