公开(公告)号：US09744031B2

公开(公告)日：2017-08-29

申请号：US13114582

申请日：2011-05-24

申请人： Michael J. Girard ,  Randy Lane ,  Arnulf Mayer

发明人： Michael J. Girard ,  Randy Lane ,  Arnulf Mayer

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2220/0025 ,  A61F2220/0075 ,  A61F2240/001

摘要： The invention relates to a prosthetic heart valve (100) for an endoprosthesis (1) used in the treatment of a stenotic cardiac valve and/or a cardiac valve insufficiency. The prosthetic heart valve (100) comprises of a plurality of leaflets (102), which consist of a natural and/or synthetic material and have a first opened position for opening the heart chamber and a second closed position for closing the heart chamber, the leaflets (102) being able to switch between their first and second position in response to the blood flow through the heart. In addition, the prosthetic heart valve (100) comprises a leaflet support portion (103), consisting of biological and/or synthetic material for mounting of the prosthetic heart valve (100) to a stent (10), and a bendable transition area (104) which forms a junction between the leaflets (102) and the leaflet support portion (103), the transition area (104) progressing essentially in a U-shaped manner similar to a cusp shape of a natural aortic or pulmonary heart valve for reducing tissue stresses during opening and closing motion of the leaflets (102). The invention further relates to an endoprosthesis (1) comprising a prosthetic heart valve (100) and a stent (10).

公开(公告)号：US08468667B2

公开(公告)日：2013-06-25

申请号：US12778625

申请日：2010-05-12

申请人： Helmut Straubinger ,  Johannes Jung ,  Arnulf Mayer ,  Michael J. Girard ,  Randy Lane ,  Amir Miller

发明人： Helmut Straubinger ,  Johannes Jung ,  Arnulf Mayer ,  Michael J. Girard ,  Randy Lane ,  Amir Miller

IPC分类号： B21D39/04

CPC分类号： A61F2/2427 ,  A61F2/2412 ,  A61F2/95 ,  A61F2002/9522 ,  Y10T29/5367 ,  Y10T29/53878 ,  Y10T29/53952

摘要： The present disclosure relates to a device for compressing a stent or a stent with a prosthetic heart valve affixed thereto, as well as a method for loading a stent into a medical delivery system. The device may comprise a compressing mechanism designed so as to exert a compressive force in radial direction on at least parts of a stent accommodated within the compressing mechanism such that the cross-section of the stent is reduced to a predefinable value at least at certain areas. The device may further comprise a manipulating mechanism moveable relative to the compressing mechanism for moving at least one clamping means in the radial direction in order to adjust the internal cross-sectional diameter of the compressing mechanism.

摘要翻译： 本公开涉及一种用于压缩固定在其上的假体心脏瓣膜的支架或支架的装置，以及用于将支架装载到医疗输送系统中的方法。 该装置可以包括压缩机构，该压缩机构设计成在容纳在压缩机构内的支架的至少一部分上沿径向施加压缩力，使得至少在某些区域将支架的横截面减小到可预定值 。 该装置还可以包括可相对于压缩机构移动的操纵机构，用于沿径向方向移动至少一个夹紧装置，以调节压缩机构的内部横截面直径。

公开(公告)号：US20100292780A1

公开(公告)日：2010-11-18

申请号：US12778625

申请日：2010-05-12

申请人： Helmut Straubinger ,  Johannes Jung ,  Arnulf Mayer ,  Michael J. Girard ,  Randy Lane ,  Amir Miller

发明人： Helmut Straubinger ,  Johannes Jung ,  Arnulf Mayer ,  Michael J. Girard ,  Randy Lane ,  Amir Miller

IPC分类号： A61F2/84

CPC分类号： A61F2/2427 ,  A61F2/2412 ,  A61F2/95 ,  A61F2002/9522 ,  Y10T29/5367 ,  Y10T29/53878 ,  Y10T29/53952

摘要： The invention relates to a device (1a-1d) for compressing a stent (100) or a stent (100) with a prosthetic heart valve affixed thereto. The invention further relates to a system as well as a method for loading a stent (100) into a medical delivery system. The device (1a-1d) according to the invention comprises a compressing mechanism (10a-10d), within which a stent (100) to be compressed can be at least partly accommodated, wherein the compressing mechanism (10a-10d) comprises externally-manipulatable clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n) and is designed so as to exert a compressive force in radial direction on at least parts of a stent (100) accommodated within the compressing mechanism (10a-10d) such that the cross-section of the stent (100) is reduced to a predefinable value at least at certain areas. The inventive device (1a-1d) further comprises a manipulating mechanism (40a-40d) for manipulating the at least one clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n), said manipulating mechanism (40a-40d) being moveable relative to the compressing mechanism (10a-10d) for moving the at least one clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n) in the radial direction in order to adjust the internal cross-sectional diameter of the compressing mechanism (10a-10d).

摘要翻译： 本发明涉及一种用于用固定在其上的假体心脏瓣膜来压缩支架（100）或支架（100）的装置（1a-1d）。 本发明还涉及一种系统以及将支架（100）装载到医疗输送系统中的方法。 根据本发明的装置（1a-1d）包括压缩机构（10a-10d），其中可以至少部分地容纳待压缩的支架（100），其中压缩机构（10a-10d） 可操纵的夹紧装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）并且被设计成在径向方向上施加压缩力至少在容纳在 压缩机构（10a-10d），使得至少在某些区域将支架（100）的横截面减小到预定值。 本发明的装置（1a-1d）还包括用于操纵至少一个夹持装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）的操纵机构（40a-40d），所述操纵 机构（40a-40d）可相对于所述压缩机构（10a-10d）移动，用于将所述至少一个夹紧装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）移动到所述径向 方向，以调节压缩机构（10a-10d）的内部横截面直径。

公开(公告)号：US20110295363A1

公开(公告)日：2011-12-01

申请号：US13114582

申请日：2011-05-24

申请人： Michael J. Girard ,  Randy Lane ,  Arnulf Mayer

发明人： Michael J. Girard ,  Randy Lane ,  Arnulf Mayer

IPC分类号： A61F2/82 ,  A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2220/0025 ,  A61F2220/0075 ,  A61F2240/001

摘要： The invention relates to a prosthetic heart valve (100) for an endoprosthesis (1) used in the treatment of a stenotic cardiac valve and/or a cardiac valve insufficiency. The prosthetic heart valve (100) comprises of a plurality of leaflets (102), which consist of a natural and/or synthetic material and have a first opened position for opening the heart chamber and a second closed position for closing the heart chamber, the leaflets (102) being able to switch between their first and second position in response to the blood flow through the heart. In addition, the prosthetic heart valve (100) comprises a leaflet support portion (103), consisting of biological and/or synthetic material for mounting of the prosthetic heart valve (100) to a stent (10), and a bendable transition area (104) which forms a junction between the leaflets (102) and the leaflet support portion (103), the transition area (104) progressing essentially in a U-shaped manner similar to a cusp shape of a natural aortic or pulmonary heart valve for reducing tissue stresses during opening and closing motion of the leaflets (102). The invention further relates to an endoprosthesis (1) comprising a prosthetic heart valve (100) and a stent (10)

摘要翻译： 本发明涉及用于治疗狭窄心脏瓣膜和/或心脏瓣膜功能不全的内用假体（1）的假体心脏瓣膜（100）。 所述假体心脏瓣膜（100）包括由天然和/或合成材料组成并且具有用于打开心室的第一打开位置和用于闭合心室的第二闭合位置的多个小叶（102）， 小叶（102）能够响应于通过心脏的血流而在它们的第一和第二位置之间切换。 此外，假体心脏瓣膜（100）包括由用于将假体心脏瓣膜（100）安装到支架（10）的生物和/或合成材料组成的小叶支撑部分（103）和可弯曲的过渡区域 104），其形成在小叶（102）和小叶支撑部分（103）之间的连接处，过渡区域（104）基本上以类似于天然主动脉或肺心脏瓣膜的尖端形状的U形方式前进，用于还原 在小叶（102）的打开和关闭运动期间的组织应力。 本发明还涉及一种包括假体心脏瓣膜（100）和支架（10）的内用假体（1）

公开(公告)号：US08790395B2

公开(公告)日：2014-07-29

申请号：US13896905

申请日：2013-05-17

申请人： Helmut Straubinger ,  Johannes Jung ,  Michael J. Girard ,  Arnulf Mayer

发明人： Helmut Straubinger ,  Johannes Jung ,  Michael J. Girard ,  Arnulf Mayer

IPC分类号： A61F2/82 ,  A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/07 ,  A61F2/2412 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0023 ,  A61F2230/0054

摘要： The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.

摘要翻译： 本发明涉及一种用于在患者心脏中的植入部位定位和锚定瓣膜假体的支架。 具体地，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内用假体的可扩张支架。 为了确保即使给予心脏的蠕动运动，固定在支架上的瓣膜假体也不会相对于支架的植入状态发生纵向位移，所以根据本发明的支架包括至少一个紧固部分 瓣膜假体可以通过其连接到支架上。 支架还包括定位拱门和保持拱门，由此至少一个定位弓连接到至少一个保持拱。

公开(公告)号：US08398704B2

公开(公告)日：2013-03-19

申请号：US12713058

申请日：2010-02-25

申请人： Helmut Straubinger ,  Johannes Jung ,  Michael J. Girard ,  Arnulf Mayer

发明人： Helmut Straubinger ,  Johannes Jung ,  Michael J. Girard ,  Arnulf Mayer

IPC分类号： A61F2/82 ,  A61F2/24

CPC分类号： A61F2/2418 ,  A61F2220/0016 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0023 ,  A61F2230/0054

摘要： The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.

摘要翻译： 本发明涉及一种用于在患者心脏中的植入部位定位和锚定瓣膜假体的支架。 具体地，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内用假体的可扩张支架。 为了确保即使给予心脏的蠕动运动，固定在支架上的瓣膜假体也不会相对于支架的植入状态发生纵向位移，所以根据本发明的支架包括至少一个紧固部分 瓣膜假体可以通过其连接到支架上。 支架还包括定位拱门和保持拱门，由此至少一个定位弓连接到至少一个保持拱。

公开(公告)号：US20110208290A1

公开(公告)日：2011-08-25

申请号：US13033023

申请日：2011-02-23

申请人： Helmut Straubinger ,  Johannes Jung ,  Michael J. Girard ,  Arnulf Mayer

发明人： Helmut Straubinger ,  Johannes Jung ,  Michael J. Girard ,  Arnulf Mayer

IPC分类号： A61F2/82

CPC分类号： A61F2/2418 ,  A61F2/07 ,  A61F2/2412 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0023 ,  A61F2230/0054

摘要： The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.

摘要翻译： 本发明涉及一种用于在患者心脏中的植入部位定位和锚定瓣膜假体的支架。 具体地，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内用假体的可扩张支架。 为了确保即使给予心脏的蠕动运动，固定在支架上的瓣膜假体也不会相对于支架的植入状态发生纵向位移，所以根据本发明的支架包括至少一个紧固部分 瓣膜假体可以通过其连接到支架上。 支架还包括定位拱门和保持拱门，由此至少一个定位弓连接到至少一个保持拱。

公开(公告)号：US08465540B2

公开(公告)日：2013-06-18

申请号：US13033023

申请日：2011-02-23

申请人： Helmut Straubinger ,  Johannes Jung ,  Michael J. Girard ,  Arnulf Mayer

发明人： Helmut Straubinger ,  Johannes Jung ,  Michael J. Girard ,  Arnulf Mayer

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/07 ,  A61F2/2412 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0023 ,  A61F2230/0054

摘要： The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.

摘要翻译： 本发明涉及一种用于在患者心脏中的植入部位定位和锚定瓣膜假体的支架。 具体地，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内用假体的可扩张支架。 为了确保即使给予心脏的蠕动运动，固定在支架上的瓣膜假体也不会相对于支架的植入状态发生纵向位移，所以根据本发明的支架包括至少一个紧固部分 瓣膜假体可以通过其连接到支架上。 支架还包括定位拱门和保持拱门，由此至少一个定位弓连接到至少一个保持拱。

公开(公告)号：US07326174B2

公开(公告)日：2008-02-05

申请号：US10839724

申请日：2004-05-04

申请人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

发明人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

IPC分类号： A61F13/00 ,  A61F2/00

CPC分类号： A61F2/2481 ,  D04B21/12 ,  D10B2509/08 ,  Y10S977/907

摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.

摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。

公开(公告)号：US06730016B1

公开(公告)日：2004-05-04

申请号：US09591875

申请日：2000-06-12

申请人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

发明人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

IPC分类号： A61F200

CPC分类号： A61F2/2481 ,  D04B21/12 ,  D10B2509/08 ,  Y10S977/907

摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.

摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并且假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。