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公开(公告)号：US08574916B2
公开(公告)日：2013-11-05
申请号：US13124808
申请日：2009-11-17
CPC分类号： G01N21/658 , Y10T436/14 , Y10T436/145555 , Y10T436/147777
摘要： A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.
摘要翻译： 一种检测三聚氰胺的方法，其包括提供一定量的SERS-活性颗粒并将SERS活性颗粒与含有三聚氰胺的溶液混合。 该方法还包括检测三聚氰胺的表面增强拉曼光谱。 上述方法可以任选地包括聚集SERS活性颗粒。 在SERS-活性颗粒与含有三聚氰胺的溶液混合之前或之后，聚集可能发生。 检测三聚氰胺的方法可以任选地包括SERS活性颗粒的浓度。 该方法还可以包括将具有比三聚氰胺选择的结合位点更高亲和力的离液剂混合到含有三聚氰胺的溶液中。 该方法还可以包括将一定数量的具有已知SERS光谱的SERS-活性标准品与含有三聚氰胺和SERS-活性颗粒的溶液混合。 测定装置和系统也被公开。
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公开(公告)号：US20110207231A1
公开(公告)日：2011-08-25
申请号：US13124808
申请日：2009-11-17
CPC分类号： G01N21/658 , Y10T436/14 , Y10T436/145555 , Y10T436/147777
摘要： A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.
摘要翻译： 一种检测三聚氰胺的方法，其包括提供一定量的SERS-活性颗粒并将SERS活性颗粒与含有三聚氰胺的溶液混合。 该方法还包括检测三聚氰胺的表面增强拉曼光谱。 上述方法可以任选地包括聚集SERS活性颗粒。 在SERS-活性颗粒与含有三聚氰胺的溶液混合之前或之后，聚集可能发生。 检测三聚氰胺的方法可以任选地包括SERS活性颗粒的浓度。 该方法还可以包括将具有比三聚氰胺选择的结合位点更高亲和力的离液剂混合到含有三聚氰胺的溶液中。 该方法还可以包括将一定数量的具有已知SERS光谱的SERS-活性标准品与含有三聚氰胺和SERS-活性颗粒的溶液混合。 测定装置和系统也被公开。
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公开(公告)号：US20100233816A1
公开(公告)日：2010-09-16
申请号：US12723462
申请日：2010-03-12
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , Y10T436/13
摘要： Methods and compositions of matter are disclosed for creating tags such as SERS nanotags which are dispersible in an organic solvent. The tags are inherently hydrophilic and may be made dispersible in an organic solvent by associating the tag with an amphiphilic polymer. Alternatively, a tag may be associated with a surfactant. In another embodiment a tag having an encapsulant of a silicon containing material may be made dispersible in an organic solvent by modifying the encapsulant surface with a hydrophobic silane. In addition, a tag having an encapsulant of a silicon containing material may be modified by the esterification of the encapsulant with an alcohol.
摘要翻译： 公开了用于产生可分散在有机溶剂中的标签如SERS纳米颗粒的方法和组合物。 标签本身是亲水性的，并且可以通过将标签与两亲性聚合物缔合而使其分散在有机溶剂中。 或者，标签可以与表面活性剂相关联。 在另一个实施方案中，具有含硅材料的密封剂的标签可以通过用疏水性硅烷改性密封剂表面而制成分散在有机溶剂中。 此外，具有含硅材料的密封剂的标签可以通过密封剂与醇的酯化来改性。
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公开(公告)号：US20110124117A1
公开(公告)日：2011-05-26
申请号：US12665379
申请日：2008-06-30
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01N33/54326 , G01N33/54346 , G01N33/54393 , G01N33/553
摘要： Methods and systems for the use of surface-enhanced Raman scattering nanotags (SERS nanotags) in various assay platforms which feature accelerated reaction kinetics. One embodiment includes a method detecting a substance of interest by associating a SERS nanotag with the substance of interest while accelerating the reaction kinetics of the association steps. This method also includes detecting a Raman spectrum of a reporter molecule associated with the SERS nanotag. The reaction kinetics of the assay may be accelerated by applying microwave radiation to the sample, heating the sample, agitating the sample, mixing the sample, vibrating the sample or other methods.
摘要翻译： 在具有加速反应动力学的各种测定平台中使用表面增强拉曼散射纳米颗粒（SERS纳米标签）的方法和系统。 一个实施方案包括通过在加速缔合步骤的反应动力学的同时使SERS纳米标记与目标物质相关联来检测感兴趣的物质的方法。 该方法还包括检测与SERS纳米颗粒相关的报告分子的拉曼光谱。 可以通过对样品施加微波辐射，加热样品，搅拌样品，混合样品，振动样品或其他方法来加速测定的反应动力学。
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