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    SERS NANOTAG ASSAYS WITH ENHANCED ASSAY KINETICS
    1.
    发明申请
    SERS NANOTAG ASSAYS WITH ENHANCED ASSAY KINETICS 审中-公开
    SERS NANOTAG测试与增强测定动力学

    公开(公告)号：US20110124117A1

    公开(公告)日：2011-05-26

    申请号：US12665379

    申请日：2008-06-30

    申请人： William E. Doering ,  Rebecca Stoermer Golightly

    发明人： William E. Doering ,  Rebecca Stoermer Golightly

    IPC分类号： G01J3/44

    CPC分类号： G01N21/658 ,  G01N33/54326 ,  G01N33/54346 ,  G01N33/54393 ,  G01N33/553

    摘要： Methods and systems for the use of surface-enhanced Raman scattering nanotags (SERS nanotags) in various assay platforms which feature accelerated reaction kinetics. One embodiment includes a method detecting a substance of interest by associating a SERS nanotag with the substance of interest while accelerating the reaction kinetics of the association steps. This method also includes detecting a Raman spectrum of a reporter molecule associated with the SERS nanotag. The reaction kinetics of the assay may be accelerated by applying microwave radiation to the sample, heating the sample, agitating the sample, mixing the sample, vibrating the sample or other methods.

    摘要翻译： 在具有加速反应动力学的各种测定平台中使用表面增强拉曼散射纳米颗粒（SERS纳米标签）的方法和系统。 一个实施方案包括通过在加速缔合步骤的反应动力学的同时使SERS纳米标记与目标物质相关联来检测感兴趣的物质的方法。 该方法还包括检测与SERS纳米颗粒相关的报告分子的拉曼光谱。 可以通过对样品施加微波辐射，加热样品，搅拌样品，混合样品，振动样品或其他方法来加速测定的反应动力学。

    Melamine assay methods and systems
    2.
    发明授权
    Melamine assay methods and systems 有权
    三聚氰胺测定方法和系统

    公开(公告)号：US08574916B2

    公开(公告)日：2013-11-05

    申请号：US13124808

    申请日：2009-11-17

    申请人： Michael J. Natan ,  Richard Griffith Freeman ,  William E. Doering ,  Rebecca Stoermer Golightly

    发明人： Michael J. Natan ,  Richard Griffith Freeman ,  William E. Doering ,  Rebecca Stoermer Golightly

    IPC分类号： G01N33/00 ,  G01J3/44

    CPC分类号： G01N21/658 ,  Y10T436/14 ,  Y10T436/145555 ,  Y10T436/147777

    摘要： A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.

    摘要翻译： 一种检测三聚氰胺的方法，其包括提供一定量的SERS-活性颗粒并将SERS活性颗粒与含有三聚氰胺的溶液混合。 该方法还包括检测三聚氰胺的表面增强拉曼光谱。 上述方法可以任选地包括聚集SERS活性颗粒。 在SERS-活性颗粒与含有三聚氰胺的溶液混合之前或之后，聚集可能发生。 检测三聚氰胺的方法可以任选地包括SERS活性颗粒的浓度。 该方法还可以包括将具有比三聚氰胺选择的结合位点更高亲和力的离液剂混合到含有三聚氰胺的溶液中。 该方法还可以包括将一定数量的具有已知SERS光谱的SERS-活性标准品与含有三聚氰胺和SERS-活性颗粒的溶液混合。 测定装置和系统也被公开。

    Melamine Assay Methods and Systems
    3.
    发明申请
    Melamine Assay Methods and Systems 有权
    三聚氰胺测定方法和系统

    公开(公告)号：US20110207231A1

    公开(公告)日：2011-08-25

    申请号：US13124808

    申请日：2009-11-17

    申请人： Michael J. Natan ,  Richard Griffith Freeman ,  William E. Doering ,  Rebecca Stoermer Golightly

    发明人： Michael J. Natan ,  Richard Griffith Freeman ,  William E. Doering ,  Rebecca Stoermer Golightly

    IPC分类号： G01N33/00 ,  G01J3/44

    CPC分类号： G01N21/658 ,  Y10T436/14 ,  Y10T436/145555 ,  Y10T436/147777

    摘要： A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.

    摘要翻译： 一种检测三聚氰胺的方法，其包括提供一定量的SERS-活性颗粒并将SERS活性颗粒与含有三聚氰胺的溶液混合。 该方法还包括检测三聚氰胺的表面增强拉曼光谱。 上述方法可以任选地包括聚集SERS活性颗粒。 在SERS-活性颗粒与含有三聚氰胺的溶液混合之前或之后，聚集可能发生。 检测三聚氰胺的方法可以任选地包括SERS活性颗粒的浓度。 该方法还可以包括将具有比三聚氰胺选择的结合位点更高亲和力的离液剂混合到含有三聚氰胺的溶液中。 该方法还可以包括将一定数量的具有已知SERS光谱的SERS-活性标准品与含有三聚氰胺和SERS-活性颗粒的溶液混合。 测定装置和系统也被公开。

    Tags Dispersible in Organic Solvents
    4.
    发明申请
    Tags Dispersible in Organic Solvents 审中-公开
    标签分散在有机溶剂中

    公开(公告)号：US20100233816A1

    公开(公告)日：2010-09-16

    申请号：US12723462

    申请日：2010-03-12

    申请人： Michael J. Natan ,  William E. Doering ,  Rebecca Stoermer Golightly

    发明人： Michael J. Natan ,  William E. Doering ,  Rebecca Stoermer Golightly

    IPC分类号： G01N21/65

    CPC分类号： G01N21/658 ,  Y10T436/13

    摘要： Methods and compositions of matter are disclosed for creating tags such as SERS nanotags which are dispersible in an organic solvent. The tags are inherently hydrophilic and may be made dispersible in an organic solvent by associating the tag with an amphiphilic polymer. Alternatively, a tag may be associated with a surfactant. In another embodiment a tag having an encapsulant of a silicon containing material may be made dispersible in an organic solvent by modifying the encapsulant surface with a hydrophobic silane. In addition, a tag having an encapsulant of a silicon containing material may be modified by the esterification of the encapsulant with an alcohol.

    摘要翻译： 公开了用于产生可分散在有机溶剂中的标签如SERS纳米颗粒的方法和组合物。 标签本身是亲水性的，并且可以通过将标签与两亲性聚合物缔合而使其分散在有机溶剂中。 或者，标签可以与表面活性剂相关联。 在另一个实施方案中，具有含硅材料的密封剂的标签可以通过用疏水性硅烷改性密封剂表面而制成分散在有机溶剂中。 此外，具有含硅材料的密封剂的标签可以通过密封剂与醇的酯化来改性。

    Particles and Methods for Long Wavelength SERS
    6.
    发明申请
    Particles and Methods for Long Wavelength SERS 有权
    长波长SERS的粒子和方法

    公开(公告)号：US20120057165A1

    公开(公告)日：2012-03-08

    申请号：US13319648

    申请日：2010-05-18

    申请人： Michael J. Natan ,  Richard Griffith Freeman ,  Marcelo Eduardo Piotti ,  William E. Doering ,  Felicia Tam

    发明人： Michael J. Natan ,  Richard Griffith Freeman ,  Marcelo Eduardo Piotti ,  William E. Doering ,  Felicia Tam

    IPC分类号： G01N21/55

    CPC分类号： G01N33/532 ,  G01N21/658 ,  G01N33/28

    摘要： Embodiments include a particle comprising a surface enhanced spectroscopy (SES)-active core and a SES-active reporter molecule associated with the SES-active core wherein said particle has a measurable SES spectrum when excited by incident light having a wavelength of at least 1400 nm. Alternative embodiments include methods of manufacturing said particle and methods of tagging a material with said particle. The particle may include an SES-active core which supports plasmon resonance at a wavelength of at least 1400 nm. The particle may comprise an anisotropic core. The particle may include an SES-active reporter molecule which is resonant at one or more wavelengths greater than or equal to 1400 nm.

    摘要翻译： 实施方案包括包含表面增强光谱（SES）活性核心和与SES活性核心相关的SES活性报道分子的颗粒，其中当波长为至少1400nm的入射光激发时，所述颗粒具有可测量的SES光谱 。 替代实施例包括制造所述颗粒的方法和用所述颗粒标记材料的方法。 颗粒可以包括在至少1400nm的波长下支持等离子体共振的SES活性核心。 颗粒可以包括各向异性核。 颗粒可以包括在大于或等于1400nm的一个或多个波长处共振的SES活性报道分子。