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公开(公告)号：US07166597B2
公开(公告)日：2007-01-23
申请号：US10362146
申请日：2001-08-22
申请人： Michael John Alberti , Ian Robert Baldwin , Mui Cheung , Stuart Cockerill , Stephen Flack , Philip Anthony Harris , David Kendall Jung , Gregory Peckham , Michael Robert Peel , Jennifer Gabriel Badiang , Kirk Stevens , James Marvin Veal
发明人： Michael John Alberti , Ian Robert Baldwin , Mui Cheung , Stuart Cockerill , Stephen Flack , Philip Anthony Harris , David Kendall Jung , Gregory Peckham , Michael Robert Peel , Jennifer Gabriel Badiang , Kirk Stevens , James Marvin Veal
IPC分类号： C07D471/04 , A61K31/437 , C07F5/02
CPC分类号： C07D471/04
摘要： Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, R2, and R4 are various substituent groups, are protein kinase inhibitors
摘要翻译： 式（I）的化合物：其盐或溶剂合物或其生理功能衍生物，其中Z为CH或N，R 1，R 2和R 4 各种取代基是蛋白激酶抑制剂
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2.发明授权Pyralopyridines, process for their preparation and use as therapeutic compounds 失效吡咯并吡啶，其制备方法和用作治疗化合物公开(公告)号：US07034030B2
公开(公告)日：2006-04-25
申请号：US10473196
申请日：2002-03-20
申请人： Michael John Alberti , Stanley D. Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Anthony Harris , Brian A. Johns , David Kendall Jung , Michael Robert Peel , Jennifer Badiang Stanford
发明人： Michael John Alberti , Stanley D. Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Anthony Harris , Brian A. Johns , David Kendall Jung , Michael Robert Peel , Jennifer Badiang Stanford
IPC分类号： C07D403/04 , A61K31/505
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译： 本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途。
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3.发明授权Pyrazolopyridines, process for their preparation and use as therapeutic compounds 失效吡唑并吡啶，其制备方法和用作治疗化合物公开(公告)号：US07109209B2
公开(公告)日：2006-09-19
申请号：US11245972
申请日：2005-10-07
申请人： Michael John Alberti , Stanley D. Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Anthony Harris , Brian A. Johns , David Kendall Jung , Michael Robert Peel , Jennifer Badiang Stanford
发明人： Michael John Alberti , Stanley D. Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Anthony Harris , Brian A. Johns , David Kendall Jung , Michael Robert Peel , Jennifer Badiang Stanford
IPC分类号： C07D471/04 , A61K31/4162
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译： 本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途。
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公开(公告)号：US07888503B2
公开(公告)日：2011-02-15
申请号：US11577444
申请日：2005-10-18
IPC分类号： C07D243/14 , A61K31/5513
CPC分类号： C07D401/04 , C07D403/04 , C07D409/14
摘要： The present invention relates to dihydrobenzodiazepine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such dihydrobenzodiazepine derivatives are useful in the treatment of diseases associated with inappropriate ROCK kinase.
摘要翻译： 本发明涉及二氢苯并二氮杂衍生物，含有它们的组合物和药物，以及这些化合物，组合物和药物的制备和用途的方法。 这样的二氢苯并二氮杂衍生物可用于治疗与不适当的ROCK激酶相关的疾病。
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公开(公告)号：US20090143366A1
公开(公告)日：2009-06-04
申请号：US11577444
申请日：2005-10-18
IPC分类号： A61K31/5513 , C07D401/10
CPC分类号： C07D401/04 , C07D403/04 , C07D409/14
摘要： The present invention relates to dihydrobenzodiazepine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such dihydrobenzodiazepine derivatives are useful in the treatment of diseases associated with inappropriate ROCK kinase.
摘要翻译： 本发明涉及二氢苯并二氮杂衍生物，含有它们的组合物和药物，以及这些化合物，组合物和药物的制备和用途的方法。 这样的二氢苯并二氮杂衍生物可用于治疗与不适当的ROCK激酶相关的疾病。
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6.发明申请PYRIDOPYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USES AS ANTI-CANCER AND ANTI-DIABETE DRUGS 审中-公开吡咯并吡嗪化合物及其作为抗癌剂和抗糖尿病药物的用途公开(公告)号：US20090054471A1
公开(公告)日：2009-02-26
申请号：US11815798
申请日：2006-02-09
IPC分类号： A61K31/519 , C07D471/14
CPC分类号： C07D471/14
摘要： The present invention relates to pyridopyrazolopyrimidine derivatives that are useful pharmacological agents through the inhibition or antagonism of protein kinases, and to processes for the preparation and use of the same. In particular, the present invention relates to compounds that demonstrate protein tyrosine kinase and/or protein serine/threonine kinase inhibition.
摘要翻译： 本发明涉及通过抑制或拮抗蛋白激酶而成为有用的药理学的吡哆吡唑并嘧啶衍生物及其制备和使用方法。 特别地，本发明涉及证明蛋白酪氨酸激酶和/或蛋白丝氨酸/苏氨酸激酶抑制的化合物。
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公开(公告)号：US07598251B2
公开(公告)日：2009-10-06
申请号：US12262290
申请日：2008-10-31
IPC分类号： A61K31/4965 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D471/04 , C07D403/04 , C07D409/14 , C07D473/00 , C07D487/04
摘要： The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
摘要翻译： 本发明涉及氨基吡嗪衍生物，含有它们的组合物和药物，以及制备和使用这些化合物，组合物和药物的方法。 这种氨基吡嗪衍生物可用于治疗与不适当的酪氨酸和/或丝氨酸/苏氨酸激酶活性相关的疾病。
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公开(公告)号：US07459454B2
公开(公告)日：2008-12-02
申请号：US10549972
申请日：2004-03-18
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , A61K31/4965 , C07D487/00 , C07D473/00 , C07D239/02 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D471/04 , C07D403/04 , C07D409/14 , C07D473/00 , C07D487/04
摘要： The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medcicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
摘要翻译： 本发明涉及氨基吡嗪衍生物，含有它们的组合物和药物，以及这些化合物，组合物和药物的制备和用途的方法。 这种氨基吡嗪衍生物可用于治疗与不适当的酪氨酸和/或丝氨酸/苏氨酸激酶活性相关的疾病。
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公开(公告)号：US20090062307A1
公开(公告)日：2009-03-05
申请号：US12262290
申请日：2008-10-31
IPC分类号： C07D409/14 , A61K31/497
CPC分类号： C07D471/04 , C07D403/04 , C07D409/14 , C07D473/00 , C07D487/04
摘要： The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
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