METHOD FOR DESIGNING AN APTAMER
    3.
    发明申请
    METHOD FOR DESIGNING AN APTAMER 失效
    设计APTAMER的方法

    公开(公告)号:US20120123760A1

    公开(公告)日:2012-05-17

    申请号:US13298830

    申请日:2011-11-17

    IPC分类号: G06G7/48

    CPC分类号: G06F19/18 G06F19/16

    摘要: Disclosed in this specification is a method for identifying at least one aptamer that can bind to a bio-molecular target. The aptamer is designed in silico based on the structure of the target molecule. The process includes the steps of determining a first seed residue and growing an oligomer, one residue at a time, while maximizing the entropy of target-oligomer complex or minimizing the binding energy after the addition of each oligomer.

    摘要翻译: 在本说明书中公开的是鉴定至少一种能够结合生物分子靶标的适体的方法。 基于目标分子的结构,适配体被设计为硅胶。 该方法包括以下步骤:确定第一种子残基并一次生长一个残基,同时最大化靶 - 低聚物复合物的熵或使加入每种低聚物后的结合能最小化。

    METHOD FOR TREATING ALZHEIMER'S DISEASE USING SUPERIOR STABILITY TUBULIN CONSRUCTS
    5.
    发明申请
    METHOD FOR TREATING ALZHEIMER'S DISEASE USING SUPERIOR STABILITY TUBULIN CONSRUCTS 审中-公开
    使用超稳定性管状体治疗ALZHEIMER病的方法

    公开(公告)号:US20160361385A1

    公开(公告)日:2016-12-15

    申请号:US15180764

    申请日:2016-06-13

    IPC分类号: A61K38/17

    CPC分类号: A61K38/1709 C07K14/47

    摘要: A method of providing a therapeutic benefit to a patient for Alzheimer's Disease (AD) is disclosed. A superior stabilizing-tubulin (SS-tubulin) is administered, either directly or indirectly through gene therapy. Mutated alpha SS-tubulins and mutated beta SS-tubulins are disclosed for use in the method.

    摘要翻译: 公开了向患者提供阿尔茨海默氏病(AD)治疗益处的方法。 通过基因治疗直接或间接施用优良的稳定 - 微管蛋白(SS-微管蛋白)。 公开了突变的α-SS-微管蛋白和突变的β-SS-微管蛋白用于该方法。

    Method for designing an aptamer
    6.
    发明授权
    Method for designing an aptamer 失效
    设计适体的方法

    公开(公告)号:US08484010B2

    公开(公告)日:2013-07-09

    申请号:US13298830

    申请日:2011-11-17

    IPC分类号: G06G7/48 G06F17/11 G06F17/50

    CPC分类号: G06F19/18 G06F19/16

    摘要: Disclosed in this specification is a method for identifying at least one aptamer that can bind to a bio-molecular target. The aptamer is designed in silico based on the structure of the target molecule. The process includes the steps of determining a first seed residue and growing an oligomer, one residue at a time, while maximizing the entropy of target-oligomer complex or minimizing the binding energy after the addition of each oligomer.

    摘要翻译: 在本说明书中公开的是鉴定至少一种能够结合生物分子靶标的适体的方法。 基于目标分子的结构,适配体被设计为硅胶。 该方法包括以下步骤:确定第一种子残基并一次生长一个残基,同时最大化靶 - 低聚物复合物的熵或使加入每种低聚物后的结合能最小化。