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公开(公告)号：US08394804B2
公开(公告)日：2013-03-12
申请号：US12288920
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, Jr. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonerd Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, Jr. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonerd Sorgi , Eugene Powell
IPC分类号： A61K31/4965 , C07D241/04 , C07D295/00
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US20090143336A1
公开(公告)日：2009-06-04
申请号：US12288920
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonerd Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonerd Sorgi , Eugene Powell
IPC分类号： A61K31/675 , C07F9/6509 , A61P29/00
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US20090118504A1
公开(公告)日：2009-05-07
申请号：US12289000
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： C07F9/6509
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US20090131671A1
公开(公告)日：2009-05-21
申请号：US12290027
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： C07F9/58
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US08497373B2
公开(公告)日：2013-07-30
申请号：US13471876
申请日：2012-05-15
申请人： Michael N. Greco , Harold R. Almond, Jr. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, Jr. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： C07D241/02 , C07F9/02 , A61K31/4965
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及可用作丝氨酸蛋白酶抑制剂的膦酸化合物，其组合物和用于治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US20090137528A1
公开(公告)日：2009-05-28
申请号：US12288993
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： A61K31/675 , C07F9/547
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US20090131371A1
公开(公告)日：2009-05-21
申请号：US12288998
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： A61K31/675 , C07F9/6509
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US20090118235A1
公开(公告)日：2009-05-07
申请号：US12290028
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： A61K31/675 , C07F9/59 , C07F9/44 , A61K31/664 , C07F9/6509
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US20120238528A1
公开(公告)日：2012-09-20
申请号：US13471876
申请日：2012-05-15
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： A61K31/675 , A61P29/00 , C07F9/6509
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及可用作丝氨酸蛋白酶抑制剂的膦酸化合物，其组合物和用于治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US20090124581A1
公开(公告)日：2009-05-14
申请号：US12288992
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： A61K31/675 , A61P17/06 , A61P9/12
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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