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公开(公告)号:US20210220404A1
公开(公告)日:2021-07-22
申请号:US17104983
申请日:2020-11-25
申请人: Michael R. Greene , Novartis AG
发明人: Aida Abujoub , John Blankenship , Attilio Bondanza , Jennifer Brogdon , Dexiu Bu , Serena De Vita , Glenn Dranoff , Boris Engels , Tony Fleming , Brian Walter Granda , Michael R. Greene , Carla Patricia Guimaraes , Anniesha Hack , Brian Holmberg , Connie Hong , Lu Huang , Olja Kodrasi , Joni Waiee Lam , Hyungwook Lim , Elizabeth Dorothy Pratico , Andrew Price , Akash Sohoni , Andrew Marc Stein , Louise Treanor , Chonghui Zhang , Xu Zhu
IPC分类号: A61K35/17 , C07K16/28 , A61P35/00 , A61K45/06 , A61K39/395 , C07K14/705 , A61K38/17 , C12N5/0783 , C07K14/725
摘要: The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.
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公开(公告)号:US11608382B2
公开(公告)日:2023-03-21
申请号:US16439495
申请日:2019-06-12
申请人: Novartis AG
发明人: Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC分类号: C07K16/28 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783 , A61K38/00
摘要: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号:US20190382500A1
公开(公告)日:2019-12-19
申请号:US16439495
申请日:2019-06-12
申请人: Novartis AG
发明人: Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC分类号: C07K16/28 , C07K14/725 , C07K14/705 , C12N5/0783 , A61P35/00 , A61K35/17
摘要: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号:US20220364055A1
公开(公告)日:2022-11-17
申请号:US17271430
申请日:2019-08-30
申请人: Novartis AG
发明人: Louise Treanor , Michael R. Greene , Jennifer Brogdon , Boris Engels , Glenn Dranoff , Olja Kodrasi , Hyungwook Lim , Akash Sohoni , Elizabeth Dorothy Pratico , Anniesha Hack , Aida Abujoub , Tony Fleming , Lu Huang , Connie Hong , John Blankenship , Brian Holmberg , Chonghui Zhang , Dexiu Bu , Andrew Price , Xu Zhu , Andrew Stein , Attilio Bondanza
IPC分类号: C12N5/0783 , A61K35/17 , A61K31/519 , A61K38/20 , C07K16/28 , C07K14/705
摘要: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.
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