利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

63 条记录 (耗时 0.048 秒)

    Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents
    9.
    发明授权
    Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents 失效
    苯氧乙酸作为醛糖还原酶抑制剂和抗高血糖药

    公开(公告)号：US5677342A

    公开(公告)日：1997-10-14

    申请号：US701144

    申请日：1996-08-21

    申请人： Michael S. Malamas ,  Iwan Guanwan

    发明人： Michael S. Malamas ,  Iwan Guanwan

    IPC分类号： A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61P3/00 ,  A61P3/10 ,  C07C45/68 ,  C07C47/575 ,  C07C59/74 ,  C07C69/712

    CPC分类号： C07C69/712 ,  C07C45/68 ,  C07C47/575 ,  C07C59/74

    摘要： This invention relates to 4-formyl-2-(naphthalenylmethyl)phenoxyacetic acids and pharmaceutically acceptable salts thereof according to formula I below, pharmaceutical compositions thereof, a method of treating hyperglycemia due to non-insulin dependent diabetes mellitus, and a method of prevention or treatment of complications associated with diabetes. ##STR1## wherein the group A is selected from the group consisting of 1-naphthyl, 2-naphthyl, optionally substituted with alkyl of from one to six carbon atoms, fluorine, chlorine, bromine, iodine, trifluoromethyl, alkoxy of from one to six carbon atoms; R.sup.1 is hydrogen or alkyl of from one to six carbon atoms; R.sup.2 is selected from hydrogen, fluorine, chlorine, bromine, iodine, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, and hydroxyl; or a pharmaceutically acceptable metal salt thereof.

    摘要翻译： 本发明涉及下述通式I的4-甲酰基-2-（萘甲基）苯氧基乙酸及其药学上可接受的盐，其药物组合物，治疗由非胰岛素依赖型糖尿病导致的高血糖症的方法，以及预防或 治疗糖尿病并发症。 其中A组选自任选被1至6个碳原子的烷基取代的1-萘基，2-萘基，氟，氯，溴，碘，三氟甲基，一个烷氧基， 六个碳原子; R1是氢或1-6个碳原子的烷基; R2选自氢，氟，氯，溴，碘，1至6个碳原子的烷基，1至6个碳原子的烷氧基和羟基; 或其药学上可接受的金属盐。

    Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxidation of low density lipoprotein
    10.
    发明授权
    Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxidation of low density lipoprotein 失效
    芳烷基-N-羟基脲作为5-脂氧合酶的抑制剂和低密度脂蛋白氧化

    公开(公告)号：US5468760A

    公开(公告)日：1995-11-21

    申请号：US148474

    申请日：1993-11-08

    申请人： Michael S. Malamas ,  James A. Nelson

    发明人： Michael S. Malamas ,  James A. Nelson

    IPC分类号： A61K31/421 ,  A61K31/42

    CPC分类号： A61K31/421

    摘要： This invention relates to compounds compounds useful in treating diseases mediated by one or more leukotrienes or oxidative modification of low density lipoprotein such as inflammation, bronchoconstriction or atherosclerosis. The compounds of this invention have the formula: ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, fluorine, chlorine, bromine, iodine, C.sub.1 -C.sub.6 alkyl, trifluoromethyl, C.sub.1 -C.sub.6 alkoxy, or C.sub.1 -C.sub.6 trifluoroalkoxy; R.sup.2 and R.sup.4 are hydrogen or methyl independently;R.sup.5 is hydrogen, methyl or hydroxy;X and Z are independently oxygen or sulfur;andY is --CH.sub.2 --, --CH(CH.sub.3)--, or --CH.dbd.CHCH(CH.sub.3)--.

    摘要翻译： 本发明涉及可用于治疗由一种或多种白细胞三烯介导的疾病或低密度脂蛋白氧化修饰如炎症，支气管收缩或动脉粥样硬化的化合物化合物。 本发明化合物具有下式：其中R 1和R 3独立地是氢，氟，氯，溴，碘，C 1 -C 6烷基，三氟甲基，C 1 -C 6烷氧基或C 1 -C 6三氟烷氧基; R2和R4独立地为氢或甲基; R5是氢，甲基或羟基; X和Z独立地是氧或硫; 并且Y是-CH 2 - ， - CH（CH 3） - 或-CH = CHCH（CH 3） - 。