Optical nanosensors comprising photoluminescent nanostructures
    1.
    发明授权
    Optical nanosensors comprising photoluminescent nanostructures 有权
    包含光致发光纳米结构的光学纳米传感器

    公开(公告)号:US08486709B2

    公开(公告)日:2013-07-16

    申请号:US12860752

    申请日:2010-08-20

    IPC分类号: G01N33/487 G01N21/76

    摘要: Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described. Generally, the nanosensors comprise a photoluminescent nanostructure and a polymer that interacts with the photoluminescent nanostructure. In some cases, the interaction between the polymer and the nanostructure can be non-covalent (e.g., via van der Waals interactions). The nanosensors comprising a polymer and a photoluminescent nanostructure may be particularly useful in determining the presence and/or concentration of relatively small molecules, in some embodiments. In addition, in some instances the nanosensors may be capable of determining relatively low concentrations of analytes, in some cases determining as little as a single molecule. In some embodiments, the interaction between the analyte and the nanosensor (e.g., between the analyte and the photoluminescent nanostructure) can be reversible, which may allow, for example, for the reuse of a nanosensor after it has been exposed to an analyte.

    摘要翻译: 通常描述与包含光致发光纳米结构的光学纳米传感器有关的系统和方法。 通常,纳米传感器包含光致发光纳米结构和与光致发光纳米结构相互作用的聚合物。 在一些情况下,聚合物和纳米结构之间的相互作用可以是非共价的(例如,通过范德华相互作用)。 在一些实施方案中,包含聚合物和光致发光纳米结构的纳米传感器可以特别用于确定相对较小分子的存在和/或浓度。 此外,在一些情况下,纳米传感器可能能够确定相对低浓度的分析物,在某些情况下确定与单个分子一样少。 在一些实施方案中,分析物和纳米传感器之间的相互作用(例如,分析物和光致发光纳米结构之间)之间的相互作用可以是可逆的,这可以允许例如纳米传感器暴露于分析物之后再利用。

    Optical Nanosensors Comprising Photoluminescent Nanostructures
    3.
    发明申请
    Optical Nanosensors Comprising Photoluminescent Nanostructures 有权
    包含光致发光纳米结构的光学纳米传感器

    公开(公告)号:US20110045523A1

    公开(公告)日:2011-02-24

    申请号:US12860752

    申请日:2010-08-20

    摘要: Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described. Generally, the nanosensors comprise a photoluminescent nanostructure and a polymer that interacts with the photoluminescent nanostructure. In some cases, the interaction between the polymer and the nanostructure can be non-covalent (e.g., via van der Waals interactions). The nanosensors comprising a polymer and a photoluminescent nanostructure may be particularly useful in determining the presence and/or concentration of relatively small molecules, in some embodiments. In addition, in some instances the nanosensors may be capable of determining relatively low concentrations of analytes, in some cases determining as little as a single molecule. In some embodiments, the interaction between the analyte and the nanosensor (e.g., between the analyte and the photoluminescent nanostructure) can be reversible, which may allow, for example, for the reuse of a nanosensor after it has been exposed to an analyte.

    摘要翻译: 通常描述与包含光致发光纳米结构的光学纳米传感器有关的系统和方法。 通常,纳米传感器包含光致发光纳米结构和与光致发光纳米结构相互作用的聚合物。 在一些情况下,聚合物和纳米结构之间的相互作用可以是非共价的(例如,通过范德华相互作用)。 在一些实施方案中,包含聚合物和光致发光纳米结构的纳米传感器可以特别用于确定相对较小分子的存在和/或浓度。 此外,在一些情况下,纳米传感器可能能够确定相对低浓度的分析物,在某些情况下确定与单个分子一样少。 在一些实施方案中,分析物和纳米传感器之间的相互作用(例如,分析物和光致发光纳米结构之间)之间的相互作用可以是可逆的,这可以允许例如纳米传感器暴露于分析物之后再利用。

    SPECTRAL IMAGING OF PHOTOLUMINESCENT MATERIALS
    6.
    发明申请
    SPECTRAL IMAGING OF PHOTOLUMINESCENT MATERIALS 审中-公开
    光致变色材料的光谱成像

    公开(公告)号:US20110204258A1

    公开(公告)日:2011-08-25

    申请号:US12965394

    申请日:2010-12-10

    IPC分类号: G01N21/64 B82Y35/00

    摘要: A near infrared imaging and detection system is configured to analyze shifts in photoluminescence of individual nanostructures such as single-walled carbon nanotubes or quantum dots upon binding an analyte. The system can be used to detect, localize, and quantify analytes down to the single-molecule level in a sample and within living cells and can be operated in a multiplex format. The system also can be configured to perform high-throughput chemical analysis of a large number of samples simultaneously. The invention has application in the highly sensitive diagnosis of disease, as well as the detection and quantitative analysis of drugs, molecular pathogens within a living organism, and environmental toxins.

    摘要翻译: 近红外成像和检测系统被配置为分析在结合分析物时单个纳米结构如单壁碳纳米管或量子点的光致发光的移动。 该系统可用于检测,定位和定量分析物,直到样品中和细胞内的单分子水平,并可以多重格式进行操作。 该系统还可以配置为同时对大量样品进行高通量化学分析。 本发明应用于疾病的高度敏感诊断,以及药物,活体内的分子病原体和环境毒素的检测和定量分析。