公开(公告)号：US20080051560A1

公开(公告)日：2008-02-28

申请号：US11736504

申请日：2007-04-17

申请人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

发明人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

IPC分类号： C07K16/00

CPC分类号： C07K16/40 ,  C12N9/1003

摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。

公开(公告)号：US20050176092A1

公开(公告)日：2005-08-11

申请号：US10830591

申请日：2004-04-22

申请人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

发明人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

IPC分类号： C12N9/10 ,  C12P21/06

CPC分类号： C07K16/40 ,  C12N9/1003

摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。