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公开(公告)号:US07422749B2
公开(公告)日:2008-09-09
申请号:US11698250
申请日:2007-01-25
申请人: Michael T. Black , Martin K. Burnham , Jason C. Fedon , John E. Hodgson , David J. Knowles , Michael A. Lonetto , Richard O. Nicholas , Leslie M. Palmer , Julie M. Pratt , Raymond W. Reichard , Martin Rosenberg , Christopher M. Traini , Judith Ward , Richard L. Warren
发明人: Michael T. Black , Martin K. Burnham , Jason C. Fedon , John E. Hodgson , David J. Knowles , Michael A. Lonetto , Richard O. Nicholas , Leslie M. Palmer , Julie M. Pratt , Raymond W. Reichard , Martin Rosenberg , Christopher M. Traini , Judith Ward , Richard L. Warren
CPC分类号: C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译: 本发明涉及新鉴定的葡萄球菌多核苷酸,由这种多核苷酸编码的多肽,这种多核苷酸和多肽的用途,以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。 本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。
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公开(公告)号:US06511839B1
公开(公告)日:2003-01-28
申请号:US09591041
申请日:2000-06-09
申请人: Pan Fong Chan , Sanjoy Biswas , David J. Holmes , Michael A. Lonetto , Leslie M. Palmer , Stephanie Van Horn , Richard L. Warren, Jr. , Magdalena Zalacain
发明人: Pan Fong Chan , Sanjoy Biswas , David J. Holmes , Michael A. Lonetto , Leslie M. Palmer , Stephanie Van Horn , Richard L. Warren, Jr. , Magdalena Zalacain
IPC分类号: C12N1511
CPC分类号: C12N9/1205 , A61K38/00
摘要: The invention provides fucose kinase promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.
摘要翻译: 本发明提供岩藻糖激酶启动子多核苷酸以及用于产生和使用这些多核苷酸的方法及其变体,激动剂和拮抗剂及其用途。
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公开(公告)号:US06548273B1
公开(公告)日:2003-04-15
申请号:US09617823
申请日:2000-07-17
申请人: Pan Fong Chan , David J. Holmes , Michael A. Lonetto , Christopher M. Traini , Magdalena Zalacain
发明人: Pan Fong Chan , David J. Holmes , Michael A. Lonetto , Christopher M. Traini , Magdalena Zalacain
IPC分类号: C12P2106
CPC分类号: C07K14/3156 , A61K38/00 , A61K39/00 , G01N33/56944
摘要: The invention provides lacR polypeptides and polynucleotides encoding lacR polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lacR polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了lacR多肽和编码lacR多肽的多核苷酸以及通过重组技术产生这种多肽的方法。 还提供了利用lacR多肽筛选抗菌化合物的方法。
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公开(公告)号:US06291230B1
公开(公告)日:2001-09-18
申请号:US09595718
申请日:2000-06-16
申请人: Magdalena Zalacain , Pan Fong Chan , David J. Holmes , Michael A. Lonetto , Stephanie Van Horn , Richard L. Warren, Jr.
发明人: Magdalena Zalacain , Pan Fong Chan , David J. Holmes , Michael A. Lonetto , Stephanie Van Horn , Richard L. Warren, Jr.
IPC分类号: C07H2104
CPC分类号: C07K14/3156 , A61K38/00
摘要: The invention provides galK promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.
摘要翻译: 本发明提供galK启动子多核苷酸以及用于产生和使用这些多核苷酸及其变体,激动剂和拮抗剂及其用途的方法。
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