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公开(公告)号：US20100317002A1
公开(公告)日：2010-12-16
申请号：US12682594
申请日：2008-10-06
申请人： Michal Daniely , Lea Madi , Tal Kaplan , Boaz Pal , Yuval Harari , Tanweer M. Zaidi , Ricardo L. Fernandez , Jinping Zhang , Ruth Katz
发明人： Michal Daniely , Lea Madi , Tal Kaplan , Boaz Pal , Yuval Harari , Tanweer M. Zaidi , Ricardo L. Fernandez , Jinping Zhang , Ruth Katz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6841 , C12Q2565/626 , C12Q2563/173
摘要： Provided is a method of identifying a genetically abnormal cell in a sputum sample, the method comprising: (a) staining a sputum sample using a morphological stain so as to identify a lower airway tract cell or lung cell in the sputum sample; and (b) staining the sputum sample using fluorescent in situ hybridization (FISH) so as to identify in the lower airway tract cell or lung cell a genetic abnormality in at least one of human chromosome 3p22.1 and 10q22-23, thereby identifying the genetically abnormal cell in the sputum sample. Also provided are methods and kits of diagnosing lung cancer by detecting a presence of genetically abnormal cells above a predetermined threshold in a sputum sample.
摘要翻译： 提供了一种鉴定痰样品中的遗传异常细胞的方法，所述方法包括：（a）使用形态染色染色痰样品，以鉴定痰样品中的下呼吸道细胞或肺细胞; 和（b）使用荧光原位杂交（FISH）对痰样品进行染色，以在下呼吸道细胞或肺细胞中识别人染色体3p22.1和10q22-23中的至少一个的遗传异常，从而鉴定 遗传异常细胞在痰样品。 还提供了通过在痰样品中检测高于预定阈值的遗传异常细胞的存在来诊断肺癌的方法和试剂盒。
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2.发明申请Circulating Tumor and Tumor Stem Cell Detection Using Genomic Specific Probes 审中-公开循环肿瘤和肿瘤干细胞检测使用基因组特异性探针公开(公告)号：US20110189670A1
公开(公告)日：2011-08-04
申请号：US13002944
申请日：2009-07-07
申请人： Ruth L Katz , Abha Khanna , Tanweer M. Zaidi , Weigong He , Ricardo L. Fernandez , Ivan Gorlov
发明人： Ruth L Katz , Abha Khanna , Tanweer M. Zaidi , Weigong He , Ricardo L. Fernandez , Ivan Gorlov
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6841 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57492 , G01N2333/70589
摘要： The present invention comprises a method of detecting circular tumor cells and methods of detecting, evaluating, or staging cancer in a patient, as well as a method of monitoring treatment of cancer in a patient using the claimed method. The method comprises contacting a sample with a CD45 binding agent; selecting the cells based on positive or negative CD45 staining; contacting the selected cells with a labeled nucleic acid probe, and detecting hybridized cells by fluorescence in situ hybridization; and analyzing a signal produced by the labels on the hybridized cells to detect the CTCs. In other embodiments, the method provides for directed to a method of determining the level of CTCs in a sample having blood cells from a patient by contacting a sample having blood cells from a patient, wherein the sample has not been pre-sorted into CD45-positive and CD45-negative cells.
摘要翻译： 本发明包括检测圆形肿瘤细胞的方法以及检测，评价或分期患者癌症的方法以及使用所要求保护的方法监测患者癌症的方法。 该方法包括使样品与CD45结合剂接触; 基于阳性或阴性CD45染色选择细胞; 使所选择的细胞与标记的核酸探针接触，并通过荧光原位杂交检测杂交细胞; 并分析由杂交细胞上的标记产生的信号以检测CTC。 在其它实施方案中，该方法提供了一种通过使来自患者具有血细胞的样品接触来确定样品中具有血细胞的样品中CTC水平的方法，其中样品尚未预分选成CD45- 阳性和CD45阴性细胞。
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公开(公告)号：USD399938S
公开(公告)日：1998-10-20
申请号：US69283
申请日：1997-03-25
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公开(公告)号：US5192893A
公开(公告)日：1993-03-09
申请号：US863615
申请日：1992-04-06
IPC分类号： H04N5/655
CPC分类号： H04N5/655
摘要： The disclosed invention relates to a video display system having a device for shielding electromagnetic radiation emitted from electrical wires which connect a video amplifier to a cathode ray tube. The device uses inexpensive unshielded wires which are recessed within a conductive shielding enclosure. The wires are connected to the cathode ray tube by a socket which is positioned at an access opening in the shielding enclosure. The invention further relates to a device for mounting a shielding enclosure to a base using tabs on the enclosure which are captured in an interference fit between the surface of the base and brackets coupled to the base.
摘要翻译： 所公开的发明涉及具有用于屏蔽从电线发射的电磁辐射的装置的视频显示系统，其将视频放大器连接到阴极射线管。 该设备使用廉价的非屏蔽线，其凹入导电屏蔽外壳内。 电线通过位于屏蔽外壳中的入口处的插座连接到阴极射线管。 本发明还涉及一种用于将屏蔽罩安装到基座上的装置，该装置使用在基座的表面和联接到基座的支架之间的过盈配合中捕获的外壳上的突出部。
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公开(公告)号：US5294994A
公开(公告)日：1994-03-15
申请号：US863612
申请日：1992-04-06
申请人： Dennis C. Robinson , Jeffrey P. Copeland , Ricardo L. Fernandez , Steve D. Venditti , Daniel J. J. Velasco
发明人： Dennis C. Robinson , Jeffrey P. Copeland , Ricardo L. Fernandez , Steve D. Venditti , Daniel J. J. Velasco
CPC分类号： G06F1/181
摘要： An computer assembly having an integral video display and processor subsystem in a single enclosure is described. The assembly contains an electrically conductive safety wall inside the enclosure which separates the interior of the enclosure into a high-voltage region where the video display components are mounted, and a low-voltage region where the processor subsystem is mounted. The enclosure has a removable rear cover which allows access to the processor subsystem for upgrading memory. An electrically conductive liner is attached to the rear cover for EMI shielding of the low-voltage region.
摘要翻译： 描述了在单个外壳中具有集成视频显示器和处理器子系统的计算机组件。 该组件在外壳内部具有导电的安全壁，其将外壳的内部分离成安装视频显示元件的高压区域以及处理器子系统安装的低电压区域。 外壳具有可拆卸的后盖，可以访问处理器子系统以升级内存。 导电衬垫连接到后盖，用于低电压区域的EMI屏蔽。
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公开(公告)号：US5227582A
公开(公告)日：1993-07-13
申请号：US864114
申请日：1992-04-06
IPC分类号： H04N5/655
CPC分类号： H04N5/655
摘要： The disclosed invention relates to a video display system having a device for shielding electromagnetic radiation emitted from electrical wires which connect a video amplifier to a cathode ray tube. The device uses inexpensive unshielded wires which are recessed within a conductive shielding enclosure. The wires are connected to the cathode ray tube by a socket which is positioned at an access opening in the shielding enclosure. The invention further relates to a device for mounting a shielding enclosure to a base using tabs on the enclosure which are captured in an interference fit between the surface of the base and brackets coupled to the base.
摘要翻译： 所公开的发明涉及具有用于屏蔽从电线发射的电磁辐射的装置的视频显示系统，其将视频放大器连接到阴极射线管。 该设备使用廉价的非屏蔽线，其凹入导电屏蔽外壳内。 电线通过位于屏蔽外壳中的入口处的插座连接到阴极射线管。 本发明还涉及一种用于将屏蔽罩安装到基座上的装置，该装置使用在基座的表面和联接到基座的支架之间的过盈配合中捕获的外壳上的突出部。
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