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    Microprojection array immunization patch and method
    1.
    发明申请
    Microprojection array immunization patch and method 审中-公开
    微量阵列免疫贴片及方法

    公开(公告)号：US20060074377A1

    公开(公告)日：2006-04-06

    申请号：US11267563

    申请日：2005-11-04

    申请人： Michel Cormier ,  James Matriano ,  Peter Daddona ,  Juanita Johnson ,  Wendy Young

    发明人： Michel Cormier ,  James Matriano ,  Peter Daddona ,  Juanita Johnson ,  Wendy Young

    IPC分类号： A61B17/20 ,  A61M37/00

    CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0046 ,  A61M2037/0061 ,  Y02A50/401

    摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.

    摘要翻译： 公开了具有微喷射阵列（10）的皮肤贴片（20），含有抗原剂和免疫应答增强佐剂的储液器（18）及其使用方法来接种动物（例如人）。 在优选实施例中，微喷射阵列（10）由光刻和微冲压钛箔（14）组成。 微注射物（12）用含有疫苗抗原和佐剂（例如葡糖胺基胞壁酰二肽）的液体制剂包衣，干燥，并使用冲击施加器施用于待接种疫苗的皮肤。 微突出物（12）产生通过角质层的浅表通路以促进抗原剂和佐剂的渗透。 可以控制抗原剂量和穿透深度。 该技术广泛适用于各种各样的治疗性疫苗，以提高功效和使用方便。

    Microprojection array immunization patch and method
    2.
    发明申请
    Microprojection array immunization patch and method 审中-公开
    微量阵列免疫贴片及方法

    公开(公告)号：US20050025778A1

    公开(公告)日：2005-02-03

    申请号：US10884603

    申请日：2004-07-01

    申请人： Michel Cormier ,  James Matriano ,  Juanita Johnson ,  Wendy Young ,  Peter Daddona

    发明人： Michel Cormier ,  James Matriano ,  Juanita Johnson ,  Wendy Young ,  Peter Daddona

    IPC分类号： A61B17/20 ,  A61M37/00 ,  A61K39/00

    CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/0046

    摘要： Microprojection members (10) having a reservoir containing an antigenic agent and methods of using such members to vaccinate mammals (e.g., humans) are disclosed. The microprojection members are used to transdermally deliver an antigenic agent (e.g., a vaccine antigen) with substantially reduced skin reactions. This is achieved by delivering an induction amount and thereafter delivering one or more subsequent booster amounts. The induction amount is relatively larger than the booster amount. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy and convenience of use.

    摘要翻译： 公开了具有含有抗原剂的储液器的微喷射构件（10）和使用这些构件对哺乳动物（例如人）进行疫苗接种的方法。 微喷射构件用于经皮递送具有显着减少的皮肤反应的抗原剂（例如疫苗抗原）。 这是通过递送诱导量并随后递送一个或多个后续加强量来实现的。 诱导量比增压量大。 该技术广泛适用于各种各样的治疗性疫苗，以提高使用的功效和使用方便性。

    Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
    3.
    发明授权
    Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure 失效
    抑制途径闭合抑制透皮药物通量降低的方法

    公开(公告)号：US07438926B2

    公开(公告)日：2008-10-21

    申请号：US09950436

    申请日：2001-09-08

    申请人： Michel Cormier ,  Juanita Johnson ,  Wei Qi Lin ,  James Matriano ,  Peter Daddona

    发明人： Michel Cormier ,  Juanita Johnson ,  Wei Qi Lin ,  James Matriano ,  Peter Daddona

    IPC分类号： A61F13/00

    CPC分类号： A61K9/703 ,  A61K9/0021 ,  A61K9/7084 ,  Y10S514/947

    摘要： This invention relates to a method for inhibiting a decrease in the transdermal flux of an agent that is being transdermally delivered or sampled over a prolonged period of time wherein the delivery or sampling involves disrupting at least the stratum corneum layer of the skin to form pathways through which the agent passes. The desired result is achieved by co-delivering or co-sampling the agent with an amount of at least one anti-healing agent wherein the amount of the anti-healing agent is effective in inhibiting a decrease in the agent transdermal flux compared to when the delivery or sampling of the agent is done under substantially identical conditions except in the absence of the anti-healing agent(s).

    摘要翻译： 本发明涉及一种用于抑制在延长的时间段内经皮递送或取样的试剂的经皮通量降低的方法，其中所述递送或取样涉及破坏至少皮肤的角质层以形成穿过 代理人通过。 期望的结果是通过将试剂与至少一种抗愈合剂的量共同递送或共同取样而实现的，其中抗愈合剂的量有效抑制试剂透皮通量的降低， 药剂的递送或取样在基本相同的条件下进行，除了不存在抗愈合剂之外。

    Drug delivery and method having coated microprojections incorporating vasoconstrictors
    6.
    发明申请
    Drug delivery and method having coated microprojections incorporating vasoconstrictors 审中-公开
    具有包含血管收缩剂的包被微粒体的药物递送和方法

    公开(公告)号：US20080226687A1

    公开(公告)日：2008-09-18

    申请号：US12154373

    申请日：2008-05-21

    申请人： Michel Cormier ,  James Matriano ,  WeiQi Lin ,  Wendy Young

    发明人： Michel Cormier ,  James Matriano ,  WeiQi Lin ,  Wendy Young

    IPC分类号： A61K9/00 ,  A61K39/00 ,  A61K31/135 ,  A61K38/38

    CPC分类号： A61K9/0021 ,  A61K45/06

    摘要： A device and method are provided for percutaneous transdermal delivery of a biologically active agent. The coating formulation containing the biologically active agent and a vasoconstrictor is applied to the skin piercing elements using known coating techniques and then dried. The device is applied to the skin of a living animal, causing the microprojections to pierce the stratum corneum and to deliver an effective dose of the biologically active agent and vasoconstrictor to the animal.

    摘要翻译： 提供了用于经皮透皮递送生物活性剂的装置和方法。 使用已知的涂覆技术将含有生物活性剂和血管收缩剂的包衣制剂施用于皮肤刺穿元件，然后干燥。 将该装置应用于活的动物的皮肤，导致微突出物刺穿角质层并向动物输送有效剂量的生物活性剂和血管收缩剂。

    Transdermal drug delivery devices having coated microprotrusions
    7.
    发明申请
    Transdermal drug delivery devices having coated microprotrusions 有权
    透皮药物递送装置具有包被的微突起

    公开(公告)号：US20060200069A1

    公开(公告)日：2006-09-07

    申请号：US11347779

    申请日：2006-02-02

    申请人： Michel Cormier ,  Wendy Young ,  Kofi Nyam ,  Peter Daddona ,  Wei-Qi Lin

    发明人： Michel Cormier ,  Wendy Young ,  Kofi Nyam ,  Peter Daddona ,  Wei-Qi Lin

    IPC分类号： A61B17/20

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

    摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

    摘要翻译： 提供了用于经皮透皮递送有效药理活性剂的装置（12）和方法。 将试剂溶解在水中以形成具有适当粘度的水性涂料溶液，以涂覆极微小的皮肤刺穿元件（10）。 使用已知的涂覆技术将涂布溶液施加到皮肤刺穿元件（10）上，然后干燥。 将装置（12）施加到活动物（例如人）的皮肤上，导致微突起（10）刺穿角质层并将治疗有效剂量的药剂递送至动物。

    Apparatus and method for transdermal delivery of epoetin-based agents
    8.
    发明申请
    Apparatus and method for transdermal delivery of epoetin-based agents 审中-公开
    用于透皮递送基于epoetin的药剂的装置和方法

    公开(公告)号：US20060182789A1

    公开(公告)日：2006-08-17

    申请号：US11355856

    申请日：2006-02-15

    申请人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    发明人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    IPC分类号： A61K38/18 ,  A61F13/02 ,  A61M31/00

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K9/06 ,  A61K38/1816 ,  A61M2037/0023 ,  A61M2037/0046

    摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, an Epoetin-based agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having an Epoetin-based agent-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the Epoetin-based agent is contained in both the coating and the hydrogel formulation.

    摘要翻译： 一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或 表皮和真皮层。 在一个实施方案中，基于Epoetin的试剂包含在施加到微喷射构件的生物相容性涂层中。 在另一个实施方案中，递送系统包括具有基于Epoetin的含药剂的水凝胶制剂的凝胶包，其在施用到患者皮肤之后设置在微突出物构件上。 在替代实施方案中，基于Epoetin的试剂包含在涂层和水凝胶制剂中。

    Apparatus and method for transdermal delivery of multiple vaccines
    9.
    发明申请
    Apparatus and method for transdermal delivery of multiple vaccines 审中-公开
    用于多种疫苗透皮递送的装置和方法

    公开(公告)号：US20050271684A1

    公开(公告)日：2005-12-08

    申请号：US11084635

    申请日：2005-03-18

    申请人： Joseph Trautman ,  Peter Daddona ,  Michel Cormier

    发明人： Joseph Trautman ,  Peter Daddona ,  Michel Cormier

    IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61K39/295 ,  A61M31/00 ,  A61M37/00 ,  C12Q1/70

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K39/00 ,  A61K2039/525 ,  A61K2039/54 ,  A61M37/00 ,  A61M2037/0023 ,  A61M2037/0046

    摘要： An apparatus and method for transdermally delivering an immunologically active agent comprising a delivery system having a microprojection array that includes a plurality of microprojections that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers, the microprojection array having a plurality of array regions, each of the array regions having a different biocompatible coating disposed thereon, wherein at least one of the array region coatings includes an immunologically active agent. In one embodiment, each coating on the array regions includes a different immunologically active agent. In another embodiment, the biocompatible coating on a first array region includes an immunologically active agent and the biocompatible coating on a second array region includes an immune response augmenting adjuvant.

    摘要翻译： 一种用于透皮递送免疫活性剂的装置和方法，其包括具有微突出物阵列的递送系统，所述微突出物阵列包括适于刺穿角质层进入下面的表皮层或表皮和真皮层的多个微突出物，所述微突出物阵列具有 多个阵列区域，所述阵列区域中的每一个具有设置在其上的不同生物相容性涂层，其中所述阵列区域涂层中的至少一个包括免疫活性剂。 在一个实施方案中，阵列区域上的每个涂层包括不同的免疫活性剂。 在另一个实施方案中，第一阵列区上的生物相容性涂层包括免疫活性剂，第二阵列区上的生物相容性涂层包括免疫应答增强佐剂。