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    Drug delivery and method having coated microprojections incorporating vasoconstrictors
    1.
    发明申请
    Drug delivery and method having coated microprojections incorporating vasoconstrictors 审中-公开
    具有包含血管收缩剂的包被微粒体的药物递送和方法

    公开(公告)号：US20080226687A1

    公开(公告)日：2008-09-18

    申请号：US12154373

    申请日：2008-05-21

    申请人： Michel Cormier ,  James Matriano ,  WeiQi Lin ,  Wendy Young

    发明人： Michel Cormier ,  James Matriano ,  WeiQi Lin ,  Wendy Young

    IPC分类号： A61K9/00 ,  A61K39/00 ,  A61K31/135 ,  A61K38/38

    CPC分类号： A61K9/0021 ,  A61K45/06

    摘要： A device and method are provided for percutaneous transdermal delivery of a biologically active agent. The coating formulation containing the biologically active agent and a vasoconstrictor is applied to the skin piercing elements using known coating techniques and then dried. The device is applied to the skin of a living animal, causing the microprojections to pierce the stratum corneum and to deliver an effective dose of the biologically active agent and vasoconstrictor to the animal.

    摘要翻译： 提供了用于经皮透皮递送生物活性剂的装置和方法。 使用已知的涂覆技术将含有生物活性剂和血管收缩剂的包衣制剂施用于皮肤刺穿元件，然后干燥。 将该装置应用于活的动物的皮肤，导致微突出物刺穿角质层并向动物输送有效剂量的生物活性剂和血管收缩剂。

    Microprojection array immunization patch and method
    3.
    发明申请
    Microprojection array immunization patch and method 审中-公开
    微量阵列免疫贴片及方法

    公开(公告)号：US20060074377A1

    公开(公告)日：2006-04-06

    申请号：US11267563

    申请日：2005-11-04

    申请人： Michel Cormier ,  James Matriano ,  Peter Daddona ,  Juanita Johnson ,  Wendy Young

    发明人： Michel Cormier ,  James Matriano ,  Peter Daddona ,  Juanita Johnson ,  Wendy Young

    IPC分类号： A61B17/20 ,  A61M37/00

    CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0046 ,  A61M2037/0061 ,  Y02A50/401

    摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.

    摘要翻译： 公开了具有微喷射阵列（10）的皮肤贴片（20），含有抗原剂和免疫应答增强佐剂的储液器（18）及其使用方法来接种动物（例如人）。 在优选实施例中，微喷射阵列（10）由光刻和微冲压钛箔（14）组成。 微注射物（12）用含有疫苗抗原和佐剂（例如葡糖胺基胞壁酰二肽）的液体制剂包衣，干燥，并使用冲击施加器施用于待接种疫苗的皮肤。 微突出物（12）产生通过角质层的浅表通路以促进抗原剂和佐剂的渗透。 可以控制抗原剂量和穿透深度。 该技术广泛适用于各种各样的治疗性疫苗，以提高功效和使用方便。

    Microprojection array immunization patch and method
    4.
    发明申请
    Microprojection array immunization patch and method 审中-公开
    微量阵列免疫贴片及方法

    公开(公告)号：US20050025778A1

    公开(公告)日：2005-02-03

    申请号：US10884603

    申请日：2004-07-01

    申请人： Michel Cormier ,  James Matriano ,  Juanita Johnson ,  Wendy Young ,  Peter Daddona

    发明人： Michel Cormier ,  James Matriano ,  Juanita Johnson ,  Wendy Young ,  Peter Daddona

    IPC分类号： A61B17/20 ,  A61M37/00 ,  A61K39/00

    CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/0046

    摘要： Microprojection members (10) having a reservoir containing an antigenic agent and methods of using such members to vaccinate mammals (e.g., humans) are disclosed. The microprojection members are used to transdermally deliver an antigenic agent (e.g., a vaccine antigen) with substantially reduced skin reactions. This is achieved by delivering an induction amount and thereafter delivering one or more subsequent booster amounts. The induction amount is relatively larger than the booster amount. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy and convenience of use.

    摘要翻译： 公开了具有含有抗原剂的储液器的微喷射构件（10）和使用这些构件对哺乳动物（例如人）进行疫苗接种的方法。 微喷射构件用于经皮递送具有显着减少的皮肤反应的抗原剂（例如疫苗抗原）。 这是通过递送诱导量并随后递送一个或多个后续加强量来实现的。 诱导量比增压量大。 该技术广泛适用于各种各样的治疗性疫苗，以提高使用的功效和使用方便性。

    Pretreatment method and system for enhancing transdermal drug delivery
    7.
    发明申请
    Pretreatment method and system for enhancing transdermal drug delivery 审中-公开
    增强透皮药物输送的预处理方法和系统

    公开(公告)号：US20050106226A1

    公开(公告)日：2005-05-19

    申请号：US10970901

    申请日：2004-10-21

    申请人： Michel Cormier ,  WeiQi Lin ,  Juanita Johnson ,  Kofi Nyam

    发明人： Michel Cormier ,  WeiQi Lin ,  Juanita Johnson ,  Kofi Nyam

    IPC分类号： A61F13/00 ,  A61K9/00 ,  A61K9/70 ,  A61M20060101 ,  A61M37/00

    CPC分类号： A61K9/7084 ,  A61K9/0021 ,  A61K9/703 ,  A61M37/0015 ,  A61M2037/0023

    摘要： A drug delivery system for delivering a biologically active agent through the skin of a patient comprises (i) a pretreatment patch adapted to be placed on the patient's skin, the pretreatment patch having a backing membrane and a microprojection array, the microprojection array being adhered to the backing membrane, the microprojection array including a plurality of microprojections adapted to pierce the stratum corneum of the patient, the pretreatment patch including a skin template that remains on the patient's skin after the pretreatment patch is applied to and removed from the patient's skin, and (ii) a gel patch having a top and bottom surface, the gel patch including a reservoir containing a hydrogel formulation, the gel patch having a skin contact area in the range of approximately 0.5-30 cm2.

    摘要翻译： 用于递送生物活性剂通过患者皮肤的药物递送系统包括（i）适于放置在患者皮肤上的预处理贴剂，所述预处理贴片具有背衬膜和微突出物阵列，所述微突出物阵列粘附到 所述背衬膜，所述微突出物阵列包括适于刺穿所述患者角质层的多个微突出物，所述预处理贴片包括在将所述预处理贴片施加到患者皮肤并从患者皮肤移除之后残留在患者皮肤上的皮肤模板，以及 （ii）具有顶部和底部表面的凝胶贴片，所述凝胶贴片包括含有水凝胶制剂的储存器，所述凝胶贴片具有在约0.5-30cm 2范围内的皮肤接触面积。

    Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
    8.
    发明授权
    Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure 失效
    抑制途径闭合抑制透皮药物通量降低的方法

    公开(公告)号：US07438926B2

    公开(公告)日：2008-10-21

    申请号：US09950436

    申请日：2001-09-08

    申请人： Michel Cormier ,  Juanita Johnson ,  Wei Qi Lin ,  James Matriano ,  Peter Daddona

    发明人： Michel Cormier ,  Juanita Johnson ,  Wei Qi Lin ,  James Matriano ,  Peter Daddona

    IPC分类号： A61F13/00

    CPC分类号： A61K9/703 ,  A61K9/0021 ,  A61K9/7084 ,  Y10S514/947

    摘要： This invention relates to a method for inhibiting a decrease in the transdermal flux of an agent that is being transdermally delivered or sampled over a prolonged period of time wherein the delivery or sampling involves disrupting at least the stratum corneum layer of the skin to form pathways through which the agent passes. The desired result is achieved by co-delivering or co-sampling the agent with an amount of at least one anti-healing agent wherein the amount of the anti-healing agent is effective in inhibiting a decrease in the agent transdermal flux compared to when the delivery or sampling of the agent is done under substantially identical conditions except in the absence of the anti-healing agent(s).

    摘要翻译： 本发明涉及一种用于抑制在延长的时间段内经皮递送或取样的试剂的经皮通量降低的方法，其中所述递送或取样涉及破坏至少皮肤的角质层以形成穿过 代理人通过。 期望的结果是通过将试剂与至少一种抗愈合剂的量共同递送或共同取样而实现的，其中抗愈合剂的量有效抑制试剂透皮通量的降低， 药剂的递送或取样在基本相同的条件下进行，除了不存在抗愈合剂之外。