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    Fourier re-binning of time-of-flight positron emission tomography data
    1.
    发明授权
    Fourier re-binning of time-of-flight positron emission tomography data 有权
    飞行时间正电子发射断层扫描数据的傅里叶重新分组

    公开(公告)号：US07417231B2

    公开(公告)日：2008-08-26

    申请号：US11316590

    申请日：2005-12-22

    申请人： Michel Defrise ,  Michael E. Casey ,  Christian J. Michel ,  Maurizio Conti

    发明人： Michel Defrise ,  Michael E. Casey ,  Christian J. Michel ,  Maurizio Conti

    IPC分类号： G01T1/166

    CPC分类号： G01T1/2985 ,  A61B6/037

    摘要： Fast reconstruction methods are provided for 3D time-of-flight (TOF) positron emission tomography (PET), based on 2D data re-binning. Starting from pre-corrected 3D TOF data, a re-binning algorithm estimates for each transaxial slice the 2D TOF sinogram. The re-binned sinograms can then be reconstructed using any algorithm for 2D TOF reconstruction. A TOF-FORE (Fourier re-binning of TOF data) algorithm is provided as an approximate re-binning algorithm obtained by extending the Fourier re-binning method for non-TOF data. In addition, two partial differential equations are identified that must be satisfied by consistent 3D TOF data, and are used to derive exact re-binning algorithms and to characterize the degree of the approximation in TOF-FORE. Numerical simulations demonstrate that TOF-FORE is more accurate than two different TOF extensions of the single-slice re-binning method, and suggest that TOF-FORE will be a valuable tool for practical TOF PET in the range of axial apertures and time resolutions typical of current scanners.

    摘要翻译： 基于2D数据重新分组，为3D飞行时间（TOF）正电子发射断层扫描（PET）提供了快速重建方法。 从预校正的3D TOF数据开始，对于每个横轴切片2D TOF正弦图进行重新分类算法。 然后可以使用用于2D TOF重建的任何算法来重构重新合并的正弦图。 提供TOF-FORE（TOF数据的傅里叶重新分组）算法作为通过扩展用于非TOF数据的傅里叶重新分组方法而获得的近似再分类算法。 此外，识别出必须通过一致的3D TOF数据来满足两个偏微分方程，并且用于导出精确的重新分组算法并且表征TOF-FORE中的近似程度。 数值模拟表明，TOF-FORE比单片重新合并方法的两种不同的TOF扩展更为准确，并且表明TOF-FORE将成为实际TOF PET在轴向孔径和时间分辨率范围内的有价值的工具 的当前扫描仪。

    Fourier re-binning of time-of- flight positron emission tomography data
    2.
    发明申请
    Fourier re-binning of time-of- flight positron emission tomography data 有权
    飞行时间正电子发射断层扫描数据的傅里叶重新分类

    公开(公告)号：US20060266946A1

    公开(公告)日：2006-11-30

    申请号：US11316590

    申请日：2005-12-22

    申请人： Michel Defrise ,  Michael Casey ,  Christian Michel ,  Maurizio Conti

    发明人： Michel Defrise ,  Michael Casey ,  Christian Michel ,  Maurizio Conti

    IPC分类号： G01T1/164

    CPC分类号： G01T1/2985 ,  A61B6/037

    摘要： Fast reconstruction methods are provided for 3D time-of-flight (TOF) positron emission tomography (PET), based on 2D data re-binning. Starting from pre-corrected 3D TOF data, a re-binning algorithm estimates for each transaxial slice the 2D TOF sinogram. The re-binned sinograms can then be reconstructed using any algorithm for 2D TOF reconstruction. A TOF-FORE (Fourier re-binning of TOF data) algorithm is provided as an approximate re-binning algorithm obtained by extending the Fourier re-binning method for non-TOF data. In addition, two partial differential equations are identified that must be satisfied by consistent 3D TOF data, and are used to derive exact re-binning algorithms and to characterize the degree of the approximation in TOF-FORE. Numerical simulations demonstrate that TOF-FORE is more accurate than two different TOF extensions of the single-slice re-binning method, and suggest that TOF-FORE will be a valuable tool for practical TOF PET in the range of axial apertures and time resolutions typical of current scanners.

    摘要翻译： 基于2D数据重新分组，为3D飞行时间（TOF）正电子发射断层扫描（PET）提供了快速重建方法。 从预校正的3D TOF数据开始，对于每个横轴切片2D TOF正弦图进行重新分类算法。 然后可以使用用于2D TOF重建的任何算法来重构重新合并的正弦图。 提供TOF-FORE（TOF数据的傅里叶重新分组）算法作为通过扩展用于非TOF数据的傅里叶重新分组方法而获得的近似再分类算法。 此外，识别出必须通过一致的3D TOF数据来满足两个偏微分方程，并且用于导出精确的重新分组算法并且表征TOF-FORE中的近似程度。 数值模拟表明，TOF-FORE比单片重新合并方法的两种不同的TOF扩展更为准确，并且表明TOF-FORE将成为实际TOF PET在轴向孔径和时间分辨率范围内的有价值的工具 的当前扫描仪。

    Iterative Image Processing
    3.
    发明申请
    Iterative Image Processing 失效
    迭代图像处理

    公开(公告)号：US20080267477A1

    公开(公告)日：2008-10-30

    申请号：US11771197

    申请日：2007-06-29

    申请人： Maurizio Conti ,  Michael E. Casey

    发明人： Maurizio Conti ,  Michael E. Casey

    IPC分类号： G06K9/00

    CPC分类号： G06T11/006 ,  G06T2211/424

    摘要： A method for processing an image which has the steps of a) receiving acquired data necessary to obtain an image and estimating a preliminary image; b) selecting at least one image element within the image; c) performing an iterative algorithm for processing the image at least on the at least one image element; d) computing a difference between the processed at least one image element and the at least one image element; and e) repeating the steps c) and d) until the difference is below a predefined threshold.

    摘要翻译： 一种用于处理图像的方法，该方法具有以下步骤：a）接收获取图像所需的获得的数据并估计初步图像; b）选择图像内的至少一个图像元素; c）执行至少在所述至少一个图像元素处理所述图像的迭代算法; d）计算所处理的至少一个图像元素与所述至少一个图像元素之间的差异; 和e）重复步骤c）和d），直到该差值低于预定阈值。

    Iterative image processing
    4.
    发明授权
    Iterative image processing 失效
    迭代图像处理

    公开(公告)号：US07949172B2

    公开(公告)日：2011-05-24

    申请号：US11771197

    申请日：2007-06-29

    申请人： Maurizio Conti ,  Michael E. Casey

    发明人： Maurizio Conti ,  Michael E. Casey

    IPC分类号： G06K9/00

    CPC分类号： G06T11/006 ,  G06T2211/424

    摘要： A method for processing an image which has the steps of a) receiving acquired data necessary to obtain an image and estimating a preliminary image; b) selecting at least one image element within the image; c) performing an iterative algorithm for processing the image at least on the at least one image element; d) computing a difference between the processed at least one image element and the at least one image element; and e) repeating the steps c) and d) until the difference is below a predefined threshold.

    摘要翻译： 一种用于处理图像的方法，该方法具有以下步骤：a）接收获取图像所需的获得的数据并估计初步图像; b）选择图像内的至少一个图像元素; c）执行至少在所述至少一个图像元素处理所述图像的迭代算法; d）计算所处理的至少一个图像元素与所述至少一个图像元素之间的差异; 和e）重复步骤c）和d），直到该差值低于预定阈值。

    Normalization apparatus for panel detector PET scanners
    6.
    发明授权
    Normalization apparatus for panel detector PET scanners 失效
    面板检测仪PET扫描仪的归一化装置

    公开(公告)号：US06963065B2

    公开(公告)日：2005-11-08

    申请号：US10418520

    申请日：2003-04-18

    申请人： Maurizio Conti ,  James J. Hamill ,  Michael E. Casey ,  Mu Chen

    发明人： Maurizio Conti ,  James J. Hamill ,  Michael E. Casey ,  Mu Chen

    IPC分类号： G01D18/00 ,  G01T1/172 ,  G01T1/29 ,  G12B13/00

    CPC分类号： G01T1/2985 ,  A61B6/037

    摘要： A normalization apparatus and method for a PET scanner with panel detectors for obtaining an estimate of a normalization array, for correction for count rate effects on the normalization array, and for measurement of the relation between the normalization array and the count rate. The method of the present invention is based on two quasi-independent radial and axial components, which are count rate dependent due to sensitivity changes across the detector blocks. A scatter source is disposed at the center of the FOV and a scatter-free source is disposed at the outer edge of the FOV. The method computes the normalization array through several steps which evaluate the geometric profile, the axial profile, and the correction factor. A count rate correction is introduced to extend the normalization array to any count rate.

    摘要翻译： 一种具有面板检测器的PET扫描仪的归一化装置和方法，用于获得归一化阵列的估计，用于校正对归一化阵列的计数率影响，以及用于测量归一化阵列与计数率之间的关系。 本发明的方法是基于两个准独立的径向和轴向分量，其由于检测器块两端的灵敏度变化而依次计数。 散射源设置在FOV的中心，并且不分散源设置在FOV的外边缘处。 该方法通过评估几何轮廓，轴向轮廓和校正因子的几个步骤来计算归一化阵列。 引入计数率校正以将归一化数组扩展到任何计数率。

    Attenuation correction for nuclear medical imaging scanners with simultaneous transmission and emission acquisition
    8.
    发明授权
    Attenuation correction for nuclear medical imaging scanners with simultaneous transmission and emission acquisition 失效
    具有同时传输和发射采集的核医学成像扫描仪的衰减校正

    公开(公告)号：US07465927B2

    公开(公告)日：2008-12-16

    申请号：US11387263

    申请日：2006-03-23

    申请人： Vladimir Panin ,  Maurizio Conti ,  Michael E. Casey

    发明人： Vladimir Panin ,  Maurizio Conti ,  Michael E. Casey

    IPC分类号： G01T1/164

    CPC分类号： G01T1/1617

    摘要： For patient transmission data acquired simultaneously with patient emission data, blank transmission data are acquired in the absence of the patient emission and therefore under count rate conditions different from the count rate conditions of the patient transmission data. To prevent the different count rate conditions from causing artifacts in reconstructed tomographic images, a correction is made for spatially varying count rate effects on the attenuation correction. For example, the blank scan data are adjusted according to the count rate at which the patient emission data are acquired, and the adjusted blank scan data and the patient transmission data are used for attenuation correction of the patient emission data used for reconstructing a tomographic image.

    摘要翻译： 对于与患者发射数据同时获得的患者传输数据，在不存在患者发射的情况下获取空白传输数据，因此在与患者传输数据的计数速率条件不同的计数速率条件下获取。 为了防止不同的计数率条件在重建的断层图像中造成伪像，对空间变化的计数率对衰减校正的影响进行了校正。 例如，根据获取患者发射数据的计数率来调整空白扫描数据，并且将经调整的空白扫描数据和患者传输数据用于用于重建断层图像的患者排放数据的衰减校正 。

    Positron emission tomography (PET) imaging using scattered and unscattered photons
    9.
    发明授权
    Positron emission tomography (PET) imaging using scattered and unscattered photons 有权
    使用散射和未散射光子的正电子发射断层扫描（PET）成像

    公开(公告)号：US08384036B2

    公开(公告)日：2013-02-26

    申请号：US12558041

    申请日：2009-09-11

    申请人： Maurizio Conti

    发明人： Maurizio Conti

    IPC分类号： G01T1/161

    CPC分类号： G01T1/2985

    摘要： Determining the position of a radioactive source in a PET system. Detecting a scatter coincidence event characterized by a full-energy photon detected at a first detector and partial-energy photon at a second detector. Measuring the arrival time difference between the partial energy photon and the full energy photon. Measuring the energy of the partial-energy photon. Determining a scattering point as a function of the position of the first detector, the position of the second detector, the energy of the partial-energy photon, the energy of an unscattered photon, the mass of a scattering electron, and the speed of light. Determining the position of a radioactive PET source along a line between the scatter point and the first detector as a function of the distance between scatter point and the first detector, the distance between scatter point and the second detector, and the measured time difference.

    摘要翻译： 确定PET系统中放射源的位置。 检测由在第一检测器处检测到的全能光子和在第二检测器处的​​部分能量光子特征的散射符号事件。 测量部分能量光子与全能光子之间的到达时间差。 测量部分能量光子的能量。 确定作为第一检测器的位置，第二检测器的位置，部分能量光子的能量，未散射光子的能量，散射电子的质量和光速的函数的散射点 。 根据散射点和第一检测器之间的距离，散射点与第二检测器之间的距离以及测量的时间差确定放射性PET源沿散射点和第一检测器之间的位置。

    Method for reducing an electronic time coincidence window in positron emission tomography
    10.
    发明授权
    Method for reducing an electronic time coincidence window in positron emission tomography 有权
    正电子发射断层扫描中减少电子时间符合窗口的方法

    公开(公告)号：US07402807B2

    公开(公告)日：2008-07-22

    申请号：US11265758

    申请日：2005-11-02

    申请人： Maurizio Conti

    发明人： Maurizio Conti

    IPC分类号： G01T1/164

    CPC分类号： G01T1/2985 ,  A61B6/037 ,  A61B8/00 ,  G01T1/1611

    摘要： A method for acquiring PET images with reduced time coincidence window limits includes obtaining a preliminary image of a patient within a radiation field of view (FOV), determining the spatial location of the patient within the FOV based on the preliminary image, calculating a different time coincidence window based on the spatial location of the patient for each possible pair of oppositely disposed detectors, scanning the patient with a PET scanning system to detect a pair of gamma photons produced by an annihilation event, determining whether the detection of the pair of gamma photons occurs within the time coincidence window, accepting the detected event only if the detection of the gamma photons occurs within the time coincidence window, calculating the spatial location of accepted annihilation event, and adding the calculated spatial location of the annihilation event to a stored distribution of calculated annihilation event spatial locations representing the distribution of radioactivity in the patient.

    摘要翻译： 用于以缩短的时间一致窗口极限获取PET图像的方法包括获得在辐射视场（FOV）内的患者的初步图像，基于初步图像确定患者在FOV内的空间位置，计算不同时间 基于每个可能的一对相对布置的检测器的患者的空间位置的重合窗口，用PET扫描系统扫描患者以检测由湮灭事件产生的一对伽马光子，确定是否检测到该对γ光子 在时间一致窗口内发生，只有当伽马光子的检测发生在时间一致窗口内时，接受检测到的事件，计算接受的湮灭事件的空间位置，并将计算出的湮灭事件的空间位置加到 计算的湮灭事件空间位置表示辐射的分布 患者的活动性