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公开(公告)号:US09248274B2
公开(公告)日:2016-02-02
申请号:US12681869
申请日:2007-10-10
申请人: Michel Troosters , Jean Delbeke , Pascal Doguet , Herve Mevel
发明人: Michel Troosters , Jean Delbeke , Pascal Doguet , Herve Mevel
CPC分类号: A61N1/36139 , A61N1/0529 , A61N1/0556 , A61N1/3605
摘要: The present invention relates to an electrode (30,30′) for implantation in contact with a neural tissue, said electrode extending along an axis, said neural tissue being capable of generating one or more action potentials, and said one or more action potentials propagating with a given speed in said neural tissue. The electrode comprises a carrier (31, 31′) of biocompatible electrically insulating material; stimulation electrode contacts (32a; 32′a; 32b; 32′b) deposited on a surface of said carrier (31, 31′) for applying an electrical stimulation to said neural tissue so as to generate, after a given latency time, a compound action potential when stimulated by said electrical stimulation; one or more sensing electrode contacts (33a; 33b; 33c; 33′a; 33′b; 33′c) deposited on said surface of said carrier and provided at a distance from said stimulation electrode contacts, said sensing electrode contacts being adapted to be connected to measuring means (23) having a given inactive period. The invention includes means to reduce the stimulation artifact. The invention also relates to an apparatus (20) and method for using various signals obtained from the stimulation probe itself and used to control the parameters of the current pulses applied to the electrodes.
摘要翻译: 本发明涉及用于植入与神经组织接触的电极(30,30'),所述电极沿轴线延伸,所述神经组织能够产生一个或多个动作电位,并且所述一个或多个动作电位传播 在所述神经组织中具有给定的速度。 电极包括生物相容的电绝缘材料的载体(31,31'); 沉积在所述载体(31,31')的表面上的刺激电极接触件(32a; 32'a; 32b; 32'b),用于对所述神经组织施加电刺激,以便在给定的潜伏时间之后产生 由所述电刺激刺激时的复合动作电位; 一个或多个感测电极触点(33a; 33b; 33c; 33'a; 33'b; 33'c),其沉积在所述载体的所述表面上并且设置在与所述刺激电极触点一定距离处,所述感测电极触点适于 连接到具有给定的非活动时段的测量装置(23)。 本发明包括减少刺激伪影的手段。 本发明还涉及一种用于使用从刺激探针本身获得的各种信号并用于控制施加到电极的电流脉冲的参数的装置(20)和方法。
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公开(公告)号:US20100222844A1
公开(公告)日:2010-09-02
申请号:US12681869
申请日:2007-10-10
申请人: Michel Troosters , Jean Delbeke , Pascal Doguet , Herve Mevel
发明人: Michel Troosters , Jean Delbeke , Pascal Doguet , Herve Mevel
CPC分类号: A61N1/36139 , A61N1/0529 , A61N1/0556 , A61N1/3605
摘要: The present invention relates to an electrode (30,30′) for implantation in contact with a neural tissue, said electrode extending along an axis, said neural tissue being capable of generating one or more action potentials, and said one or more action potentials propagating with a given speed in said neural tissue. The electrode comprises a carrier (31, 31′) of biocompatible electrically insulating material; stimulation electrode contacts (32a; 32′a; 32b; 32′b) deposited on a surface of said carrier (31, 31′) for applying an electrical stimulation to said neural tissue so as to generate, after a given latency time, a compound action potential when stimulated by said electrical stimulation; one or more sensing electrode contacts (33a; 33b; 33c; 33′a; 33′b; 33′c) deposited on said surface of said carrier and provided at a distance from said stimulation electrode contacts, said sensing electrode contacts being adapted to be connected to measuring means (23) having a given inactive period. The invention includes means to reduce the stimulation artifact. The invention also relates to an apparatus (20) and method for using various signals obtained from the stimulation probe itself and used to control the parameters of the current pulses applied to the electrodes.
摘要翻译: 本发明涉及一种用于植入与神经组织接触的电极(30,30'),所述电极沿轴线延伸,所述神经组织能够产生一个或多个动作电位,并且所述一个或多个动作电位传播 在所述神经组织中具有给定的速度。 电极包括生物相容的电绝缘材料的载体(31,31'); 沉积在所述载体(31,31')的表面上的刺激电极接触件(32a; 32'a; 32b; 32'b),用于对所述神经组织施加电刺激,以便在给定的潜伏时间之后产生 由所述电刺激刺激时的复合动作电位; 一个或多个感测电极触点(33a; 33b; 33c; 33'a; 33'b; 33'c),其沉积在所述载体的所述表面上并且设置在与所述刺激电极触点一定距离处,所述感测电极触点适于 连接到具有给定的非活动时段的测量装置(23)。 本发明包括减少刺激伪影的手段。 本发明还涉及一种用于使用从刺激探针本身获得的各种信号并用于控制施加到电极的电流脉冲的参数的装置(20)和方法。
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公开(公告)号:US20100233226A1
公开(公告)日:2010-09-16
申请号:US12681755
申请日:2008-10-14
申请人: Etienne Ferain , Delphine Magnin , Sophie Demoustier-Champagne , Marie-Anne Thil , Jean Delbeke , Ides Colin
发明人: Etienne Ferain , Delphine Magnin , Sophie Demoustier-Champagne , Marie-Anne Thil , Jean Delbeke , Ides Colin
IPC分类号: A61F2/00 , A61N1/04 , C25D5/02 , A61K31/573 , A61K39/395 , A61K31/616 , A61K31/7088 , A61K38/18 , A61K38/17 , A61K38/43 , A61P35/00 , A61P29/00 , A61P3/02 , A61P39/06 , A61P25/16 , A61P25/18 , A61P25/06 , A61P25/08
CPC分类号: A61L31/06 , A61K9/0009 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2300/258 , A61L2300/41 , A61L2300/602 , A61L2400/12 , A61N1/04 , A61N1/05 , A61N1/0529 , A61N1/0534 , A61N1/0536 , A61N1/30 , B82Y5/00 , C08L69/00 , C08L39/00
摘要: The present invention relates to a nanowire array (15, 16) for electrically-controlled elution of a therapeutic composition (5) comprising a plurality of nanoscopic-sized wires (12, 12), nanowires, attached to an electrically conducting solid support (7), said nanowires formed from electroactive conjugated polymer (4) containing or doped with said therapeutic composition (5) coated over a plurality of nanoscopic sized electrically conducting protrusions (8). It also relates to a method for preparing a nanowire array and an electrode.
摘要翻译: 本发明涉及一种用于电控洗脱治疗组合物(5)的纳米线阵列(15,16),其包括连接到导电固体支持体(7)上的多个纳米级尺寸的导线(12,12),纳米线 ),由包含或掺杂有涂覆在多个纳米尺寸的导电突起(8)上的所述治疗组合物(5)的电活性共轭聚合物(4)形成的所述纳米线。 它还涉及一种制备纳米线阵列和电极的方法。
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