公开(公告)号：US4148912A

公开(公告)日：1979-04-10

申请号：US442351

申请日：1974-02-14

Applicant: Michel Vincent ,  Georges Remond ,  Xavier Pascaud

Inventor： Michel Vincent ,  Georges Remond ,  Xavier Pascaud

IPC: C07F5/06 ,  C07F9/94 ,  A61K31/295 ,  A61K31/195 ,  A61K31/205 ,  A61K31/29

CPC classification number: C07F5/069 ,  C07F9/94

Abstract: The present application relates to pharmaceutical compositions incorporating as active ingredient p.chlorohippuric acid or one of its mineral or organic base addition salts.The pharmaceutical compositions are those adapted for parenteral or oral administration. They may include another active ingredient.The present application also extends to therapeutic methods for using the said pharmaceutical compositions namely for protecting the gastric mucosa from acid hypersecretion, ulcers from therapeutic origin and for protecting the liver from toxic aggressions.

Abstract translation: 本申请涉及作为活性成分掺入氯丙酸或其矿物或有机碱加成盐之一的药物组合物。

公开(公告)号：US4048313A

公开(公告)日：1977-09-13

申请号：US540032

申请日：1975-01-09

Applicant: Michel Vincent ,  Georges Remond ,  Xavier Pascaud ,  Jean-Claude Poignant

Inventor： Michel Vincent ,  Georges Remond ,  Xavier Pascaud ,  Jean-Claude Poignant

IPC: C07D295/22 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/00 ,  A61P1/04 ,  A61P21/02 ,  A61P25/00 ,  C07C67/00 ,  C07C301/00 ,  C07C303/38 ,  C07C303/40 ,  C07C311/46 ,  C07D211/60 ,  C07D295/26 ,  C07D295/00

CPC classification number: C07D295/26 ,  C07D211/60 ,  Y10S514/872 ,  Y10S514/926 ,  Y10S514/927

Abstract: This application relates to benzenesulphonamides and more specifically to 1-acylamino 2- alcoxy or alcenyloxy 5-morpholinylsulfonyl benzenes and their salts with a mineral or organic acid. It also relates to processes for producing these compounds.The disclosed compounds are useful for stimulating gastric evacuation while inhibiting emisis and gastric secretion in warm-blooded animals.

Abstract translation: 本申请涉及苯磺酰胺，更具体地涉及1-酰氨基2-烷氧基或烯丙氧基-5-吗啉基磺酰基苯及其与矿物或有机酸的盐。 它还涉及生产这些化合物的方法。

公开(公告)号：US4954640A

公开(公告)日：1990-09-04

申请号：US462797

申请日：1990-01-10

Applicant: Michel Vincent ,  Jean Baliarda ,  Bernard Marchand ,  Georges Remond

Inventor： Michel Vincent ,  Jean Baliarda ,  Bernard Marchand ,  Georges Remond

IPC: C07B61/00 ,  C07C211/27 ,  C07D209/42 ,  C07K1/02 ,  C07K5/02 ,  C07K5/06

CPC classification number: C07K5/0222 ,  C07D209/42

Abstract: Process for the industrial synthesis of (2S,3 7aS)-2-carboxyperhydroindole by reduction of 2-carboxindole or of one of its esters to (R,S)-2-carboxyindo or of one of its esters which, after saponification, converted into the acid, the S isomer cf (R,S)-2-carboxyindoline being obtained by precipitation from the mixture of the two (R) and (S) isomers, in the presence of (+) methylbenzylamine, (S)-2-carboxyindoline being in its turn subjected to catalytic hydrogenation to give (2S, 3aS,7aS)-2-carboxyperhydroindole, after separation of (2S,3aR,7aR) isomer by crystallization.Application to the synthesis of carboxyalkyl d peptides capable of being employed in therapeutics.

公开(公告)号：US4616029A

公开(公告)日：1986-10-07

申请号：US659275

申请日：1984-10-10

Applicant: Michel Vincent ,  Georges Remond ,  Michel Laubie

Inventor： Michel Vincent ,  Georges Remond ,  Michel Laubie

IPC: A61K38/00 ,  C07D209/42 ,  C07D209/44 ,  C07D217/26 ,  C07D339/08 ,  C07D471/04 ,  C07D495/04 ,  A61K31/40

CPC classification number: C07D471/04 ,  C07D209/42 ,  C07D209/44 ,  C07D217/26 ,  C07D339/08 ,  C07D495/04 ,  A61K38/00

Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.

Abstract translation: 通式为：其中：A环饱和，n = 0或1，或环A为苯环，n = 1，R 1表示可带有氨基的低级烷基，R 2 表示氢原子或低级烷基，R 3表示直链或支链烷基，不多于总共9个碳原子的一或二环烷基烷基或苯基烷基，或取代的烷基，以及盐 其中。 这些化合物可用作治疗药物。

公开(公告)号：US4565819A

公开(公告)日：1986-01-21

申请号：US420005

申请日：1982-09-20

Applicant: Michel Vincent ,  Georges Remond ,  Michel Laubie

Inventor： Michel Vincent ,  Georges Remond ,  Michel Laubie

IPC: A61K38/00 ,  C07D209/42 ,  C07D209/44 ,  C07D217/26 ,  C07D339/08 ,  C07D471/04 ,  C07D495/04 ,  A61K31/47

CPC classification number: C07D471/04 ,  C07D209/42 ,  C07D209/44 ,  C07D217/26 ,  C07D339/08 ,  C07D495/04 ,  A61K38/00

Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.

Abstract translation: 通式为：其中：A环饱和，n = 0或1，或环A为苯环，n = 1，R 1表示可带有氨基的低级烷基，R 2 表示氢原子或低级烷基，R 3表示直链或支链烷基，不多于总共9个碳原子的一或二环烷基烷基或苯基烷基，或取代的烷基，以及盐 其中。 这些化合物可用作治疗药物。

公开(公告)号：US4508729A

公开(公告)日：1985-04-02

申请号：US308234

申请日：1981-10-02

Applicant: Michel Vincent ,  Georges Remond ,  Michel Laubie

Inventor： Michel Vincent ,  Georges Remond ,  Michel Laubie

IPC: A61K38/00 ,  C07D209/44 ,  C07D217/26 ,  C07D339/08 ,  C07K5/02 ,  C07K5/06 ,  C07D209/34 ,  A61K31/405

CPC classification number: C07K5/06026 ,  C07D209/44 ,  C07D217/26 ,  C07D339/08 ,  C07K5/022 ,  A61K38/00

Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.

Abstract translation: 通式为：其中：A环饱和，n = 0或1，或环A为苯环，n = 1，R 1表示可带有氨基的低级烷基，R 2 表示氢原子或低级烷基，R 3表示直链或支链烷基，不多于总共9个碳原子的一或二环烷基烷基或苯基烷基，或取代的烷基，以及盐 其中。 这些化合物可用作治疗药物。

公开(公告)号：US4086355A

公开(公告)日：1978-04-25

申请号：US649943

申请日：1976-01-19

Applicant: Michel Vincent ,  Georges Remond ,  Jean-Claude Poignant

Inventor： Michel Vincent ,  Georges Remond ,  Jean-Claude Poignant

IPC: C07D491/113 ,  A61K31/40 ,  A61P25/08 ,  A61P25/20 ,  C07C45/67 ,  C07D209/54 ,  C07D317/72 ,  C07D319/08 ,  C07D487/10

CPC classification number: C07D319/08 ,  C07C45/673 ,  C07D209/54 ,  C07D317/72

Abstract: The invention relates to novel spirodecane derivatives and more specifically to novel azaspirodecane diones.The invention also provides process for producing said azaspirodecane diones which consists mainly in cyclizing a disubstituted glutaronitrile or a glutaric acid in the presence of an amino compound.The compounds of the present invention have interesting pharmacological properties and they find therapeutical uses.

Abstract translation: 本发明涉及新的螺十二烷衍生物，更具体地涉及新的氮杂十一烷二恶英。

公开(公告)号：US5565429A

公开(公告)日：1996-10-15

申请号：US439233

申请日：1995-05-11

Applicant: Michel Vincent ,  Guillaume de Nanteuil ,  Georges Remond ,  Bernard Portevin ,  Yolande Herve ,  Emmanuel Canet ,  Michel Lonchampt

Inventor： Michel Vincent ,  Guillaume de Nanteuil ,  Georges Remond ,  Bernard Portevin ,  Yolande Herve ,  Emmanuel Canet ,  Michel Lonchampt

IPC: A61K38/00 ,  A61P29/00 ,  C07K1/10 ,  C07K5/06 ,  C07K5/08 ,  C07K5/083 ,  C07K5/087 ,  C07K5/09 ,  C07K14/81 ,  C07K5/00 ,  C07K7/00 ,  C07K17/00

CPC classification number: C07K5/06191 ,  A61K38/00

Abstract: Compounds of formula (I): ##STR1## wherein: R.sub.1 represents an unsubstituted or substituted alkyl,R.sub.2 represents an unsubstituted or substituted alkyl,A represents, with the nitrogen and carbon atoms to which it is attached, a nitrogenous mono- or polycyclic structure, andB represent any one of the radicals a through j as defined in the description, and medicaments containing the same, are useful as human leucocyte elastase inhibitors.

Abstract translation: 式（I）的化合物：其中：R 1表示未取代或取代的烷基，R 2表示未取代或取代的烷基，A表示与其连接的氮和碳原子， 或多环结构，B表示说明书中定义的基团a至j中的任一个，含有该基团的药物可用作人白细胞弹性蛋白酶抑制剂。

公开(公告)号：US4959372A

公开(公告)日：1990-09-25

申请号：US237497

申请日：1988-08-26

Applicant: Michel Vincent ,  Georges Remond ,  Michel Laubie

Inventor： Michel Vincent ,  Georges Remond ,  Michel Laubie

IPC: C07D453/02 ,  A61K31/435 ,  A61K38/00 ,  A61P1/16 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/04 ,  A61P27/02 ,  A61P29/00 ,  A61P43/00 ,  C07K5/02

CPC classification number: C07K5/0222 ,  A61K38/00

Abstract: Compounds of formula (I): ##STR1## in which E denotes a lower alkyl group, or preferably a hydrogen atom, and their addition salts with a pharmaceutically acceptable acid or base, the preparation thereof and pharmaceutical compositions containing them.

Abstract translation: 式（I）化合物：其中E表示低级烷基，优选氢原子，及其与药学上可接受的酸或碱的加成盐，其制备方法和含有它们的药物组合物。

公开(公告)号：US4914214A

公开(公告)日：1990-04-03

申请号：US245446

申请日：1988-09-16

Applicant: Michel Vincent ,  Jean Baliarda ,  Bernard Marchand ,  Georges Remond

Inventor： Michel Vincent ,  Jean Baliarda ,  Bernard Marchand ,  Georges Remond

IPC: C07D209/42 ,  A61K38/00 ,  B01J23/00 ,  B01J23/40 ,  B01J23/755 ,  C07B31/00 ,  C07B53/00 ,  C07B61/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/18 ,  C07C227/32 ,  C07C229/16 ,  C07K1/02 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81

CPC classification number: C07K5/0222 ,  A61K38/00

Abstract: Process for the industrial synthesis of perindopril, in which (2S,3aS,7aS)-2-carboxyperhydroindole is condensed with N-[(S)-1-carbethoxybutyl]-(S)-alanine after protection of the carboxyl group, the product resulting from the condensation being then subjected to deprotection of the carboxyl carried by the heterocyclic ring.The (2S,3aS,7aS)-2-carboxyperhydroindole and N-[(S)-1-carbethoxybutyl]-(S)-alanine are themselves obtained in excellent conditions from 2-carboxyindole and from L-alanine respectively, both available on an industrial scale.

Abstract translation: 在保护羧基后，（2S，3aS，7aS）-2-羧基全氢吲哚与N - [（S）-1-乙酯基] - （S） - 丙氨酸缩合的培养基工业合成方法，产物 由缩合得到的杂环进行羧基负载脱保护。 （2S，3aS，7aS）-2-羧基全氢吲哚和N - [（S）-1-甲乙氧基丁基] - （S） - 丙氨酸本身分别在2-羧基吲哚和L-丙氨酸的良好条件下得到， 工业规模。