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1.发明申请Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof 审中-公开与心血管疾病和药物反应相关的遗传多态性，检测方法及其应用公开(公告)号：US20050272054A1
公开(公告)日：2005-12-08
申请号：US10995561
申请日：2004-11-24
申请人： Michele Cargill , Olga Iakoubova , James Devlin , Zenta Tsuchihashi , Peter Shaw , Lynn Ploughman , Kim Zerba , Koustubh Ranade , Todd Kirchgessner
发明人： Michele Cargill , Olga Iakoubova , James Devlin , Zenta Tsuchihashi , Peter Shaw , Lynn Ploughman , Kim Zerba , Koustubh Ranade , Todd Kirchgessner
IPC分类号： A61K31/225 , G01N33/50 , G01N33/68 , C12Q1/68
CPC分类号： C12Q1/6883 , A61K31/22 , A61K31/225 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2800/32 , G01N2800/324
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与心血管疾病特别是急性冠状动脉事件如心肌梗塞和中风相关的遗传多态性的发现，以及与个体对用他汀类药物治疗心血管疾病的反应性相关的遗传多态性。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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2.发明申请Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof 审中-公开与心肌梗死相关的遗传多态性，检测方法及其应用公开(公告)号：US20070042382A1
公开(公告)日：2007-02-22
申请号：US10796307
申请日：2004-03-10
申请人： Michele Cargill , James Devlin , Olga Iakoubova , Dov Shiffman
发明人： Michele Cargill , James Devlin , Olga Iakoubova , Dov Shiffman
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与心肌梗塞相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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3.发明申请Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof 有权与心肌梗死相关的遗传多态性，检测方法及其应用公开(公告)号：US20050026169A1
公开(公告)日：2005-02-03
申请号：US10741600
申请日：2003-12-22
申请人： Michele Cargill , James Devlin , Olga Iakoubova
发明人： Michele Cargill , James Devlin , Olga Iakoubova
IPC分类号： A61B20060101 , C07H21/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N15/12 , C12P19/34 , G01N33/53 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与心肌梗塞相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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4.发明授权公开(公告)号：US07482117B2
公开(公告)日：2009-01-27
申请号：US10741600
申请日：2003-12-22
申请人： Michele Cargill , James J. Devlin , Olga Iakoubova
发明人： Michele Cargill , James J. Devlin , Olga Iakoubova
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
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5.发明申请Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof 审中-公开与心肌梗死相关的遗传多态性，检测方法及其应用公开(公告)号：US20080248476A1
公开(公告)日：2008-10-09
申请号：US11977366
申请日：2007-10-23
申请人： Michele Cargill , James J. Devlin , Olga Iakoubova , Dov Shiffman
发明人： Michele Cargill , James J. Devlin , Olga Iakoubova , Dov Shiffman
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与心肌梗塞相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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6.发明申请Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof 有权与心肌梗死相关的遗传多态性，检测方法及其应用公开(公告)号：US20090118217A1
公开(公告)日：2009-05-07
申请号：US12287505
申请日：2008-10-08
申请人： Michele Cargill , James J. Devlin , Olga Iakoubova
发明人： Michele Cargill , James J. Devlin , Olga Iakoubova
IPC分类号： A61K31/7088 , C12Q1/68 , A61P9/10
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与心肌梗塞相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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7.发明申请Genetic polymorphisms associated with stroke, methods of detection and uses thereof 审中-公开与中风相关的遗传多态性，检测方法及其应用公开(公告)号：US20070059710A1
公开(公告)日：2007-03-15
申请号：US11066316
申请日：2005-02-25
申请人： May Luke , James Devlin , Michele Cargill
发明人： May Luke , James Devlin , Michele Cargill
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with vascular diseases, particularly stroke. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与血管疾病特别是中风相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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8.发明申请Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof 审中-公开与冠心病相关的遗传多态性，检测方法及其用途公开(公告)号：US20060228715A1
公开(公告)日：2006-10-12
申请号：US11073360
申请日：2005-03-07
申请人： Dov Shiffman , Michele Cargill , James Devlin
发明人： Dov Shiffman , Michele Cargill , James Devlin
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N5/06 , C07K14/705 , C07K16/28 , A61K31/401 , A61K31/22 , A61K31/366
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease, and in particular MI, and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与冠心病相关的遗传多态性的发现，特别是MI和对药物治疗的反应。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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9.发明申请Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof 有权与冠心病相关的遗传多态性，检测方法及其用途公开(公告)号：US20060223093A1
公开(公告)日：2006-10-05
申请号：US11375359
申请日：2006-03-13
申请人： May Luke , James Devlin , Dov Shiffman , Michele Cargill
发明人： May Luke , James Devlin , Dov Shiffman , Michele Cargill
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular stenosis and MI and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与冠心病相关的遗传多态性的发现，特别是狭窄和MI以及对药物治疗的反应。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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10.发明申请Genetic polymorphisms associated with vascular, methods of detection and uses thereof 审中-公开与血管相关的遗传多态性，检测方法及其用途公开(公告)号：US20050287559A1
公开(公告)日：2005-12-29
申请号：US11124368
申请日：2005-05-09
申请人： Michele Cargill , James Devlin , May Luke
发明人： Michele Cargill , James Devlin , May Luke
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with vascular diseases and in particular coronary artery disease and stenosis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与血管疾病特别是冠状动脉疾病和狭窄相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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