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公开(公告)号：US20050215583A1
公开(公告)日：2005-09-29
申请号：US11080102
申请日：2005-03-14
申请人： Michelle Arkin , Jennifer Hyde , Duncan Walker , Jasmin Wright
发明人： Michelle Arkin , Jennifer Hyde , Duncan Walker , Jasmin Wright
IPC分类号： A61K31/44 , A61K31/4745
CPC分类号： A61K31/4375 , A61K9/0019 , A61K31/282 , A61K31/337 , A61K31/395 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/555 , A61K31/585 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K38/15 , A61K38/1816 , A61K41/00 , A61K45/06 , A61K47/12 , C07D471/04 , F24S10/70 , F24S50/40 , F24S60/30 , F24S80/60 , H01L31/0547 , H02S40/38 , Y02E10/40 , Y02E10/52 , A61K2300/00
摘要： The present invention relates to SNS-595 and methods of treating cancer using the same.
摘要翻译： 本发明涉及SNS-595及使用其的癌症治疗方法。
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公开(公告)号：US20110263524A1
公开(公告)日：2011-10-27
申请号：US13095111
申请日：2011-04-27
申请人： Michelle Arkin , Jennifer Hyde , Duncan Walker , Jasmin Wright
发明人： Michelle Arkin , Jennifer Hyde , Duncan Walker , Jasmin Wright
IPC分类号： A61K31/7068 , A61P35/02 , A61P35/00
摘要： The present invention relates to SNS-595 and methods of treating cancer using the same.
摘要翻译： 本发明涉及SNS-595及使用其的癌症治疗方法。
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公开(公告)号：US20060063795A1
公开(公告)日：2006-03-23
申请号：US11218653
申请日：2005-09-02
申请人： Michelle Arkin , Jennifer Hyde , Duncan Walker , Jasmin Wright
发明人： Michelle Arkin , Jennifer Hyde , Duncan Walker , Jasmin Wright
IPC分类号： A61K31/4745 , C12Q1/68
摘要： The present invention relates to SNS-595 and methods of treating cancer using the same.
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![Therapeutic combinations comprising (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid](/abs-image/US/2011/06/28/US07968565B2/abs.jpg.150x150.jpg)
4.发明授权Therapeutic combinations comprising (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid 有权包含（+） - 1,4-二氢-7 - [（3S，4S）-3-甲氧基-4-（甲基氨基）-1-吡咯烷基] -4-氧代-1-（2-噻唑基）-1 ，8-萘啶-3-羧酸公开(公告)号：US07968565B2
公开(公告)日：2011-06-28
申请号：US11080102
申请日：2005-03-14
申请人： Michelle Arkin , Jennifer Hyde , Duncan Walker , Jasmin Wright
发明人： Michelle Arkin , Jennifer Hyde , Duncan Walker , Jasmin Wright
CPC分类号： A61K31/4375 , A61K9/0019 , A61K31/282 , A61K31/337 , A61K31/395 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/555 , A61K31/585 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K38/15 , A61K38/1816 , A61K41/00 , A61K45/06 , A61K47/12 , C07D471/04 , F24S10/70 , F24S50/40 , F24S60/30 , F24S80/60 , H01L31/0547 , H02S40/38 , Y02E10/40 , Y02E10/52 , A61K2300/00
摘要： The present invention relates to SNS-595 and methods of treating cancer using the same.
摘要翻译： 本发明涉及SNS-595及使用其的癌症治疗方法。
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![Methods of using(+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4 -oxo-1-(2-thiazolyl)- 1,8-naphthyridine-3-carboxylic acid for treatment of cancer](/abs-image/US/2009/10/22/US20090263393A1/abs.jpg.150x150.jpg)
5.发明申请Methods of using(+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4 -oxo-1-(2-thiazolyl)- 1,8-naphthyridine-3-carboxylic acid for treatment of cancer 有权使用（+） - 1,4-二氢-7 - [（3s，4s）-3-甲氧基-4-（甲基氨基）-1-吡咯烷基] -4-氧代-1-（2-噻唑基）-1 ，8-萘啶-3-羧酸，用于治疗癌症公开(公告)号：US20090263393A1
公开(公告)日：2009-10-22
申请号：US11991349
申请日：2006-09-05
申请人： Daniel C. Adelman , Jeffrey A. Silverman , Michelle Arkin , Jennifer Hyde , Duncan Walker , Jasmine Wright
发明人： Daniel C. Adelman , Jeffrey A. Silverman , Michelle Arkin , Jennifer Hyde , Duncan Walker , Jasmine Wright
IPC分类号： A61K39/395 , A61K31/4375 , A61P35/02 , C07D471/04 , A61K31/513
CPC分类号： A61K31/4375 , A61K31/513 , A61K45/06
摘要： Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.
摘要翻译： 公开了治疗，预防或治疗癌症的方法，包括某些白血病。 该方法包括给予对映体纯的（+） - 1,4-二氢-7 - [（3S，4S）-3-甲氧基-4-（甲基氨基）-1-吡咯烷基] -4-氧代-1-（2 -1,3-噻唑基）-1,8-二氮杂萘-3-羧酸。 还提供了使用化合物与化疗，放射治疗，激素治疗，生物治疗或免疫治疗的治疗方法。 还公开了适用于该方法的药物组合物和单一单位剂型。
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公开(公告)号：US20060274993A1
公开(公告)日：2006-12-07
申请号：US11441944
申请日：2006-05-26
申请人： Daniel Mahgerefteh , Duncan Walker , Roeland Nuyts
发明人： Daniel Mahgerefteh , Duncan Walker , Roeland Nuyts
IPC分类号： G02B6/28
CPC分类号： G02B6/29358 , G02B5/288 , G02B6/29392 , G02B6/29394 , H04B10/25133
摘要： This invention provides a flat dispersion frequency discriminator (FDFD) capable of having a substantially flat dispersion with either a positive or negative dispersion along the spectrum region of the discriminator. This way, a FDFD may not cause substantial distortion of the intensity patter of its output to minimize the occurrence distortion due to overshooting or undershooting of the intensity pattern depending on the relative spectral alignment of the laser output relative to the filter transmission.
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公开(公告)号：US20050129072A1
公开(公告)日：2005-06-16
申请号：US10786839
申请日：2004-02-25
申请人： Parviz Tayebati , Kevin McCallion , Duncan Walker
发明人： Parviz Tayebati , Kevin McCallion , Duncan Walker
IPC分类号： G02B6/34 , G02F1/01 , G02F1/29 , H01S3/10 , H01S5/00 , H01S5/06 , H01S5/12 , H01S5/14 , H01S5/40
CPC分类号： G02F1/29 , G02B6/2931 , G02B6/29311 , G02F1/0147 , G02F2201/16 , H01S5/005 , H01S5/02284 , H01S5/0612 , H01S5/12 , H01S5/141 , H01S5/146 , H01S5/4012 , H01S5/4031 , H01S5/4075 , H01S5/4087
摘要： Apparatus is disclosed for optically steering an optical beam, the apparatus comprising a pair of optical prism components arranged together with a diffraction grating so as to allow efficient coupling of an array of spectrally and spatially offset laser diodes to a common optical fiber. A method of optically steering at least one of a series of optical beams is disclosed, the method comprising providing a pair of optical prism components comprising a thermo-optic material; actuating at least one of the components so as to steer at least one of the series of optical beams received from an array of spatially and spectrally offset lasers.
摘要翻译： 公开了用于光学转向光束的装置，该装置包括与衍射光栅一起布置的一对光学棱镜部件，以便允许频谱和空间偏移的激光二极管的阵列与公共光纤的有效耦合。 公开了一种光学地转向一系列光束中的至少一个的方法，该方法包括提供包括热光材料的一对光学棱镜部件; 致动所述组件中的至少一个，以便引导从空间和频谱偏移激光器的阵列接收的所述一系列光束中的至少一个。
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公开(公告)号：US07630425B2
公开(公告)日：2009-12-08
申请号：US10786839
申请日：2004-02-25
申请人： Parviz Tayebati , Kevin McCallion , Duncan Walker
发明人： Parviz Tayebati , Kevin McCallion , Duncan Walker
IPC分类号： H01S3/08
CPC分类号： G02F1/29 , G02B6/2931 , G02B6/29311 , G02F1/0147 , G02F2201/16 , H01S5/005 , H01S5/02284 , H01S5/0612 , H01S5/12 , H01S5/141 , H01S5/146 , H01S5/4012 , H01S5/4031 , H01S5/4075 , H01S5/4087
摘要： Apparatus is disclosed for optically steering an optical beam, the apparatus comprising a pair of optical prism components arranged together with a diffraction grating so as to allow efficient coupling of an array of spectrally and spatially offset laser diodes to a common optical fiber. A method of optically steering at least one of a series of optical beams is disclosed, the method comprising providing a pair of optical prism components comprising a thermo-optic material; actuating at least one of the components so as to steer at least one of the series of optical beams received from an array of spatially and spectrally offset lasers.
摘要翻译： 公开了用于光学转向光束的装置，该装置包括与衍射光栅一起布置的一对光学棱镜部件，以便允许频谱和空间偏移的激光二极管的阵列与公共光纤的有效耦合。 公开了一种光学地转向一系列光束中的至少一个的方法，该方法包括提供包括热光材料的一对光学棱镜部件; 致动所述组件中的至少一个，以便引导从空间和频谱偏移激光器的阵列接收的所述一系列光束中的至少一个。
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9.发明申请Method and apparatus for transmitting a signal using thermal chirp management of a directly modulated transmitter 有权使用直接调制发射机的热啁啾管理发送信号的方法和装置公开(公告)号：US20050111852A1
公开(公告)日：2005-05-26
申请号：US10933081
申请日：2004-09-02
申请人： Daniel Mahgerefteh , Roeland Nuyts , Yasuhiro Matsui , Parviz Tayebati , Bart Johnson , Duncan Walker , Xueyan Zheng
发明人： Daniel Mahgerefteh , Roeland Nuyts , Yasuhiro Matsui , Parviz Tayebati , Bart Johnson , Duncan Walker , Xueyan Zheng
IPC分类号： G02B5/28 , G02B6/34 , H04B10/155 , H04B10/18 , H04B10/04
CPC分类号： H04B10/504 , G02B5/281 , G02B6/29358 , G02B6/29362 , G02B6/29394 , G02B6/29398 , H04B10/25133 , H04B10/58
摘要： A fiber optic transmitter comprising a digital driver adapted to adjust the crossing point of a digital base signal, an optical source adapted to receive the digital base signal and produce a frequency modulated optical signal, and an optical spectrum reshaper adapted to convert the frequency modulated optical signal to an amplitude modulated optical signal. A method for transmitting a signal, comprising: adjusting the crossing point of a digital base signal; providing the adjusted signal to an optical source to produce a frequency modulated optical signal; and providing the frequency modulated optical signal to an optical spectrum reshaper to convert the frequency modulated optical signal to an amplitude modulated optical signal.
摘要翻译： 一种光纤发射器，包括适于调节数字基本信号的交叉点的数字驱动器，适于接收数字基本信号并产生调频光信号的光源，以及适于将频率调制光 信号到幅度调制光信号。 一种用于发送信号的方法，包括：调整数字基本信号的交叉点; 将经调整的信号提供给光源以产生调频光信号; 并将频率调制的光信号提供给光谱整形器，以将频率调制的光信号转换成幅度调制的光信号。
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10.发明授权Chirp managed directly modulated laser with bandwidth limiting optical spectrum reshaper 有权啁啾管理直接调制激光器带宽限制光谱整形公开(公告)号：US07536113B2
公开(公告)日：2009-05-19
申请号：US11037718
申请日：2005-01-18
IPC分类号： H04B10/06
CPC分类号： H04B10/504
摘要： A fiber optic communication system, comprising: an optical signal source adapted to produce a frequency modulated signal; and an optical spectrum reshaper adapted to receive the frequency modulated signal and output a substantially amplitude modulated signal; wherein the optical spectrum reshaper limits the bandwidth of the frequency modulated signal.
摘要翻译： 一种光纤通信系统，包括：适于产生调频信号的光信号源; 以及适于接收所述调频信号并输出基本幅度调制信号的光谱整形器; 其中光谱整形器限制了调频信号的带宽。
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