公开(公告)号：US20100104508A1

公开(公告)日：2010-04-29

申请号：US12444130

申请日：2007-10-01

申请人： Michelle Kuhne ,  Peter Brams ,  Dawn M. Tanamachi ,  Alan Korman ,  Josephine M. Cardarelli

发明人： Michelle Kuhne ,  Peter Brams ,  Dawn M. Tanamachi ,  Alan Korman ,  Josephine M. Cardarelli

IPC分类号： A61K51/00 ,  C07K16/28 ,  A61K39/395 ,  C07H21/04 ,  C12N15/63 ,  C12N5/00 ,  C12P21/06 ,  C12N5/02

CPC分类号： C07K16/2866 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76

摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CXCR4, as well as methods for treating various cancers, inflammatory disorders and HIV infection using an anti-CXCR4 antibody of this disclosure.

摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合CXCR4的分离的单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了用于检测CXCR4的方法，以及使用本公开的抗CXCR4抗体治疗各种癌症，炎性疾病和HIV感染的方法。

公开(公告)号：US08450464B2

公开(公告)日：2013-05-28

申请号：US12444130

申请日：2007-10-01

申请人： Michelle Kuhne ,  Peter Brams ,  Dawn M. Tanamachi ,  Alan J. Korman ,  Josephine M. Cardarelli

发明人： Michelle Kuhne ,  Peter Brams ,  Dawn M. Tanamachi ,  Alan J. Korman ,  Josephine M. Cardarelli

IPC分类号： C07K16/28 ,  C07K16/00 ,  A61K39/395

CPC分类号： C07K16/2866 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76

摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CXCR4, as well as methods for treating various cancers, inflammatory disorders and HIV infection using an anti-CXCR4 antibody of this disclosure.

摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合CXCR4的分离的单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了用于检测CXCR4的方法，以及使用本公开的抗CXCR4抗体治疗各种癌症，炎性疾病和HIV感染的方法。